Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases
Ectodysplasin A (EDA) signaling is initially identified as morphogenic signaling regulating the formation of skin appendages including teeth, hair follicles, exocrine glands in mammals, feathers in birds and scales in fish. Gene mutation in EDA signaling causes hypohidrotic ectodermal dysplasia (HED...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/16/8911 |
| _version_ | 1797432075104550912 |
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| author | Ruihan Yang Yilan Mei Yuhan Jiang Huiling Li Ruixi Zhao Jian Sima Yuyuan Yao |
| author_facet | Ruihan Yang Yilan Mei Yuhan Jiang Huiling Li Ruixi Zhao Jian Sima Yuyuan Yao |
| author_sort | Ruihan Yang |
| collection | DOAJ |
| description | Ectodysplasin A (EDA) signaling is initially identified as morphogenic signaling regulating the formation of skin appendages including teeth, hair follicles, exocrine glands in mammals, feathers in birds and scales in fish. Gene mutation in EDA signaling causes hypohidrotic ectodermal dysplasia (HED), a congenital hereditary disease with malformation of skin appendages. Interestingly, emerging evidence suggests that EDA and its receptors can modulate the proliferation, apoptosis, differentiation and migration of cancer cells, and thus may regulate tumorigenesis and cancer progression. More recently, as a newly discovered hepatocyte factor, EDA pathway has been demonstrated to be involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and type II diabetes by regulating glucose and lipid metabolism. In this review, we summarize the function of EDA signaling from skin appendage development to multiple other diseases, and discuss the clinical application of recombinant EDA protein as well as other potential targets for disease intervention. |
| first_indexed | 2024-03-09T09:56:04Z |
| format | Article |
| id | doaj.art-20fb1c5675944f729aed1dd943374eea |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T09:56:04Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-20fb1c5675944f729aed1dd943374eea2023-12-01T23:46:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012316891110.3390/ijms23168911Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple DiseasesRuihan Yang0Yilan Mei1Yuhan Jiang2Huiling Li3Ruixi Zhao4Jian Sima5Yuyuan Yao6Laboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, ChinaLaboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, ChinaLaboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, ChinaLaboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, ChinaLaboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, ChinaLaboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, ChinaLaboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, ChinaEctodysplasin A (EDA) signaling is initially identified as morphogenic signaling regulating the formation of skin appendages including teeth, hair follicles, exocrine glands in mammals, feathers in birds and scales in fish. Gene mutation in EDA signaling causes hypohidrotic ectodermal dysplasia (HED), a congenital hereditary disease with malformation of skin appendages. Interestingly, emerging evidence suggests that EDA and its receptors can modulate the proliferation, apoptosis, differentiation and migration of cancer cells, and thus may regulate tumorigenesis and cancer progression. More recently, as a newly discovered hepatocyte factor, EDA pathway has been demonstrated to be involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and type II diabetes by regulating glucose and lipid metabolism. In this review, we summarize the function of EDA signaling from skin appendage development to multiple other diseases, and discuss the clinical application of recombinant EDA protein as well as other potential targets for disease intervention.https://www.mdpi.com/1422-0067/23/16/8911EDA signalingskin appendageHEDcancerNAFLD |
| spellingShingle | Ruihan Yang Yilan Mei Yuhan Jiang Huiling Li Ruixi Zhao Jian Sima Yuyuan Yao Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases International Journal of Molecular Sciences EDA signaling skin appendage HED cancer NAFLD |
| title | Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases |
| title_full | Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases |
| title_fullStr | Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases |
| title_full_unstemmed | Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases |
| title_short | Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases |
| title_sort | ectodysplasin a eda signaling from skin appendage to multiple diseases |
| topic | EDA signaling skin appendage HED cancer NAFLD |
| url | https://www.mdpi.com/1422-0067/23/16/8911 |
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