COVID-19 Biogenesis and Intracellular Transport
SARS-CoV-2 is responsible for the COVID-19 pandemic. The structure of SARS-CoV-2 and most of its proteins of have been deciphered. SARS-CoV-2 enters cells through the endocytic pathway and perforates the endosomes’ membranes, and its (+) RNA appears in the cytosol. Then, SARS-CoV-2 starts to use the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/5/4523 |
| _version_ | 1797615218859180032 |
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| author | Alexander A. Mironov Maksim A. Savin Galina V. Beznoussenko |
| author_facet | Alexander A. Mironov Maksim A. Savin Galina V. Beznoussenko |
| author_sort | Alexander A. Mironov |
| collection | DOAJ |
| description | SARS-CoV-2 is responsible for the COVID-19 pandemic. The structure of SARS-CoV-2 and most of its proteins of have been deciphered. SARS-CoV-2 enters cells through the endocytic pathway and perforates the endosomes’ membranes, and its (+) RNA appears in the cytosol. Then, SARS-CoV-2 starts to use the protein machines of host cells and their membranes for its biogenesis. SARS-CoV-2 generates a replication organelle in the reticulo-vesicular network of the zippered endoplasmic reticulum and double membrane vesicles. Then, viral proteins start to oligomerize and are subjected to budding within the ER exit sites, and its virions are passed through the Golgi complex, where the proteins are subjected to glycosylation and appear in post-Golgi carriers. After their fusion with the plasma membrane, glycosylated virions are secreted into the lumen of airways or (seemingly rarely) into the space between epithelial cells. This review focuses on the biology of SARS-CoV-2’s interactions with cells and its transport within cells. Our analysis revealed a significant number of unclear points related to intracellular transport in SARS-CoV-2-infected cells. |
| first_indexed | 2024-03-11T07:22:18Z |
| format | Article |
| id | doaj.art-20fc48471c9d44f5bc9a1bebe61f7348 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:22:18Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-20fc48471c9d44f5bc9a1bebe61f73482023-11-17T07:49:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01245452310.3390/ijms24054523COVID-19 Biogenesis and Intracellular TransportAlexander A. Mironov0Maksim A. Savin1Galina V. Beznoussenko2Department of Cell Biology, IFOM ETS—The AIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milan, ItalyThe Department for Welding Production and Technology of Constructional Materials, Perm National Research Polytechnic University, Komsomolsky Prospekt, 29, 614990 Perm, RussiaDepartment of Cell Biology, IFOM ETS—The AIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milan, ItalySARS-CoV-2 is responsible for the COVID-19 pandemic. The structure of SARS-CoV-2 and most of its proteins of have been deciphered. SARS-CoV-2 enters cells through the endocytic pathway and perforates the endosomes’ membranes, and its (+) RNA appears in the cytosol. Then, SARS-CoV-2 starts to use the protein machines of host cells and their membranes for its biogenesis. SARS-CoV-2 generates a replication organelle in the reticulo-vesicular network of the zippered endoplasmic reticulum and double membrane vesicles. Then, viral proteins start to oligomerize and are subjected to budding within the ER exit sites, and its virions are passed through the Golgi complex, where the proteins are subjected to glycosylation and appear in post-Golgi carriers. After their fusion with the plasma membrane, glycosylated virions are secreted into the lumen of airways or (seemingly rarely) into the space between epithelial cells. This review focuses on the biology of SARS-CoV-2’s interactions with cells and its transport within cells. Our analysis revealed a significant number of unclear points related to intracellular transport in SARS-CoV-2-infected cells.https://www.mdpi.com/1422-0067/24/5/4523COVID-19SARS-CoV-2Golgi complexvirion buddingendocytosisviral replication |
| spellingShingle | Alexander A. Mironov Maksim A. Savin Galina V. Beznoussenko COVID-19 Biogenesis and Intracellular Transport International Journal of Molecular Sciences COVID-19 SARS-CoV-2 Golgi complex virion budding endocytosis viral replication |
| title | COVID-19 Biogenesis and Intracellular Transport |
| title_full | COVID-19 Biogenesis and Intracellular Transport |
| title_fullStr | COVID-19 Biogenesis and Intracellular Transport |
| title_full_unstemmed | COVID-19 Biogenesis and Intracellular Transport |
| title_short | COVID-19 Biogenesis and Intracellular Transport |
| title_sort | covid 19 biogenesis and intracellular transport |
| topic | COVID-19 SARS-CoV-2 Golgi complex virion budding endocytosis viral replication |
| url | https://www.mdpi.com/1422-0067/24/5/4523 |
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