Hybrid Nanoassemblies from Viruses and DNA Nanostructures
Viruses are among the most intriguing nanostructures found in nature. Their atomically precise shapes and unique biological properties, especially in protecting and transferring genetic information, have enabled a plethora of biomedical applications. On the other hand, structural DNA nanotechnology...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/11/6/1413 |
| _version_ | 1797532441499402240 |
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| author | Sofia Ojasalo Petteri Piskunen Boxuan Shen Mauri A. Kostiainen Veikko Linko |
| author_facet | Sofia Ojasalo Petteri Piskunen Boxuan Shen Mauri A. Kostiainen Veikko Linko |
| author_sort | Sofia Ojasalo |
| collection | DOAJ |
| description | Viruses are among the most intriguing nanostructures found in nature. Their atomically precise shapes and unique biological properties, especially in protecting and transferring genetic information, have enabled a plethora of biomedical applications. On the other hand, structural DNA nanotechnology has recently emerged as a highly useful tool to create programmable nanoscale structures. They can be extended to user defined devices to exhibit a wide range of static, as well as dynamic functions. In this review, we feature the recent development of virus-DNA hybrid materials. Such structures exhibit the best features of both worlds by combining the biological properties of viruses with the highly controlled assembly properties of DNA. We present how the DNA shapes can act as “structured” genomic material and direct the formation of virus capsid proteins or be encapsulated inside symmetrical capsids. Tobacco mosaic virus-DNA hybrids are discussed as the examples of dynamic systems and directed formation of conjugates. Finally, we highlight virus-mimicking approaches based on lipid- and protein-coated DNA structures that may elicit enhanced stability, immunocompatibility and delivery properties. This development also paves the way for DNA-based vaccines as the programmable nano-objects can be used for controlling immune cell activation. |
| first_indexed | 2024-03-10T11:00:12Z |
| format | Article |
| id | doaj.art-20fea4cb814546e5af8fa01fc5690595 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T11:00:12Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-20fea4cb814546e5af8fa01fc56905952023-11-21T21:34:00ZengMDPI AGNanomaterials2079-49912021-05-01116141310.3390/nano11061413Hybrid Nanoassemblies from Viruses and DNA NanostructuresSofia Ojasalo0Petteri Piskunen1Boxuan Shen2Mauri A. Kostiainen3Veikko Linko4Biohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, P.O. Box 16100, 00076 Aalto, FinlandBiohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, P.O. Box 16100, 00076 Aalto, FinlandBiohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, P.O. Box 16100, 00076 Aalto, FinlandBiohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, P.O. Box 16100, 00076 Aalto, FinlandBiohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, P.O. Box 16100, 00076 Aalto, FinlandViruses are among the most intriguing nanostructures found in nature. Their atomically precise shapes and unique biological properties, especially in protecting and transferring genetic information, have enabled a plethora of biomedical applications. On the other hand, structural DNA nanotechnology has recently emerged as a highly useful tool to create programmable nanoscale structures. They can be extended to user defined devices to exhibit a wide range of static, as well as dynamic functions. In this review, we feature the recent development of virus-DNA hybrid materials. Such structures exhibit the best features of both worlds by combining the biological properties of viruses with the highly controlled assembly properties of DNA. We present how the DNA shapes can act as “structured” genomic material and direct the formation of virus capsid proteins or be encapsulated inside symmetrical capsids. Tobacco mosaic virus-DNA hybrids are discussed as the examples of dynamic systems and directed formation of conjugates. Finally, we highlight virus-mimicking approaches based on lipid- and protein-coated DNA structures that may elicit enhanced stability, immunocompatibility and delivery properties. This development also paves the way for DNA-based vaccines as the programmable nano-objects can be used for controlling immune cell activation.https://www.mdpi.com/2079-4991/11/6/1413DNA nanotechnologyDNA origamiviruscapsidproteinnanofabrication |
| spellingShingle | Sofia Ojasalo Petteri Piskunen Boxuan Shen Mauri A. Kostiainen Veikko Linko Hybrid Nanoassemblies from Viruses and DNA Nanostructures Nanomaterials DNA nanotechnology DNA origami virus capsid protein nanofabrication |
| title | Hybrid Nanoassemblies from Viruses and DNA Nanostructures |
| title_full | Hybrid Nanoassemblies from Viruses and DNA Nanostructures |
| title_fullStr | Hybrid Nanoassemblies from Viruses and DNA Nanostructures |
| title_full_unstemmed | Hybrid Nanoassemblies from Viruses and DNA Nanostructures |
| title_short | Hybrid Nanoassemblies from Viruses and DNA Nanostructures |
| title_sort | hybrid nanoassemblies from viruses and dna nanostructures |
| topic | DNA nanotechnology DNA origami virus capsid protein nanofabrication |
| url | https://www.mdpi.com/2079-4991/11/6/1413 |
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