Adiponectin and Leptin Synovial Fluid Concentration as a Marker for the Severity of Knee Osteoarthritis in Obese Patients
Purpose: Osteoarthritis (OA) is a chronic degenerative joint disorder of the synovial joint characterized by loss of articular cartilage, osteophyte formation, and alterations of subchondral bone. An increase of weight bearing affect on knee joint biomechanically and alter concentration of adipokine...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cukurova University
2015-12-01
|
| Series: | Çukurova Üniversitesi Tıp Fakültesi Dergisi |
| Subjects: | |
| Online Access: | http://www.scopemed.org/fulltextpdf.php?mno=183317 |
| _version_ | 1797910078615977984 |
|---|---|
| author | Eddy Mart Salim Radiyati Umi Partan Muhammad Mukti Syarifuddin Muhammad Hermansyah Hermansyah |
| author_facet | Eddy Mart Salim Radiyati Umi Partan Muhammad Mukti Syarifuddin Muhammad Hermansyah Hermansyah |
| author_sort | Eddy Mart Salim |
| collection | DOAJ |
| description | Purpose: Osteoarthritis (OA) is a chronic degenerative joint disorder of the synovial joint characterized by loss of articular cartilage, osteophyte formation, and alterations of subchondral bone. An increase of weight bearing affect on knee joint biomechanically and alter concentration of adipokines, such as adiponectin and leptin. Herein we reported a correlation between adiponectin and leptin synovial fluid concentration with the severity of knee OA in obese patients.
Material and Methods: Totally 45 patients were included in this research. ELISA was used to determine adiponectin and leptin concentrations of synovial fluid. The severity of knee OA was classified by Kellgren-Lawrence grading scale. Data analysis was conducted using SPSS for windows.
Results: Based on the leptin measurement, it was shown that leptin concentrations were correlated positively with the severity of knee OA. Vice versa, adiponectin concentrations were correlated negative.
Conclusion: Our study was support the biomarker function of adiponectin and leptin concentration on synovial fluids, in which those concentrations were related with the severity of OA. Those results also suggested the function of leptin and adiponectin on OA. [Cukurova Med J 2015; 40(4.000): 746-756] |
| first_indexed | 2024-04-10T11:18:39Z |
| format | Article |
| id | doaj.art-20fecccd50414a7993ae2409cbc3f738 |
| institution | Directory Open Access Journal |
| issn | 0250-5150 |
| language | English |
| last_indexed | 2024-04-10T11:18:39Z |
| publishDate | 2015-12-01 |
| publisher | Cukurova University |
| record_format | Article |
| series | Çukurova Üniversitesi Tıp Fakültesi Dergisi |
| spelling | doaj.art-20fecccd50414a7993ae2409cbc3f7382023-02-15T16:18:43ZengCukurova UniversityÇukurova Üniversitesi Tıp Fakültesi Dergisi0250-51502015-12-01404746756183317Adiponectin and Leptin Synovial Fluid Concentration as a Marker for the Severity of Knee Osteoarthritis in Obese PatientsEddy Mart Salim0Radiyati Umi Partan1Muhammad Mukti2Syarifuddin Muhammad3Hermansyah Hermansyah4Division of Rheumatology, Department of Internal Medicine, Dr. Mohammad Hoesin Central General Hospital, Medical Faculty, Sriwijaya University, Palembang, South Sumatera, Indonesia Division of Rheumatology, Department of Internal Medicine, Dr. Mohammad Hoesin Central General Hospital, Medical Faculty, Sriwijaya University, Palembang, South Sumatera, Indonesia Division of Rheumatology, Department of Internal Medicine, Dr. Mohammad Hoesin Central General Hospital, Medical Faculty, Sriwijaya University, Palembang, South Sumatera, Indonesia Division of Rheumatology, Department of Internal Medicine, Dr. Mohammad Hoesin Central General Hospital, Medical Faculty, Sriwijaya University, Palembang, South Sumatera, Indonesia Division of Rheumatology, Department of Internal Medicine, Dr. Mohammad Hoesin Central General Hospital, Medical Faculty, Sriwijaya University, Palembang, South Sumatera, IndonesiaPurpose: Osteoarthritis (OA) is a chronic degenerative joint disorder of the synovial joint characterized by loss of articular cartilage, osteophyte formation, and alterations of subchondral bone. An increase of weight bearing affect on knee joint biomechanically and alter concentration of adipokines, such as adiponectin and leptin. Herein we reported a correlation between adiponectin and leptin synovial fluid concentration with the severity of knee OA in obese patients. Material and Methods: Totally 45 patients were included in this research. ELISA was used to determine adiponectin and leptin concentrations of synovial fluid. The severity of knee OA was classified by Kellgren-Lawrence grading scale. Data analysis was conducted using SPSS for windows. Results: Based on the leptin measurement, it was shown that leptin concentrations were correlated positively with the severity of knee OA. Vice versa, adiponectin concentrations were correlated negative. Conclusion: Our study was support the biomarker function of adiponectin and leptin concentration on synovial fluids, in which those concentrations were related with the severity of OA. Those results also suggested the function of leptin and adiponectin on OA. [Cukurova Med J 2015; 40(4.000): 746-756]http://www.scopemed.org/fulltextpdf.php?mno=183317Adiponectin; Knee osteoarthritis; Kellgren-Lawrence; Leptin; Obese |
| spellingShingle | Eddy Mart Salim Radiyati Umi Partan Muhammad Mukti Syarifuddin Muhammad Hermansyah Hermansyah Adiponectin and Leptin Synovial Fluid Concentration as a Marker for the Severity of Knee Osteoarthritis in Obese Patients Çukurova Üniversitesi Tıp Fakültesi Dergisi Adiponectin; Knee osteoarthritis; Kellgren-Lawrence; Leptin; Obese |
| title | Adiponectin and Leptin Synovial Fluid Concentration as a Marker for the Severity of Knee Osteoarthritis in Obese Patients |
| title_full | Adiponectin and Leptin Synovial Fluid Concentration as a Marker for the Severity of Knee Osteoarthritis in Obese Patients |
| title_fullStr | Adiponectin and Leptin Synovial Fluid Concentration as a Marker for the Severity of Knee Osteoarthritis in Obese Patients |
| title_full_unstemmed | Adiponectin and Leptin Synovial Fluid Concentration as a Marker for the Severity of Knee Osteoarthritis in Obese Patients |
| title_short | Adiponectin and Leptin Synovial Fluid Concentration as a Marker for the Severity of Knee Osteoarthritis in Obese Patients |
| title_sort | adiponectin and leptin synovial fluid concentration as a marker for the severity of knee osteoarthritis in obese patients |
| topic | Adiponectin; Knee osteoarthritis; Kellgren-Lawrence; Leptin; Obese |
| url | http://www.scopemed.org/fulltextpdf.php?mno=183317 |
| work_keys_str_mv | AT eddymartsalim adiponectinandleptinsynovialfluidconcentrationasamarkerfortheseverityofkneeosteoarthritisinobesepatients AT radiyatiumipartan adiponectinandleptinsynovialfluidconcentrationasamarkerfortheseverityofkneeosteoarthritisinobesepatients AT muhammadmukti adiponectinandleptinsynovialfluidconcentrationasamarkerfortheseverityofkneeosteoarthritisinobesepatients AT syarifuddinmuhammad adiponectinandleptinsynovialfluidconcentrationasamarkerfortheseverityofkneeosteoarthritisinobesepatients AT hermansyahhermansyah adiponectinandleptinsynovialfluidconcentrationasamarkerfortheseverityofkneeosteoarthritisinobesepatients |