Inhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity

Inhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity

Obesity is accompanied by metabolic alterations characterized by insulin resistance and cardiac lipotoxicity. Galectin-3 (Gal-3) induces cardiac inflammation and fibrosis in the context of obesity; however, its role in the metabolic consequences of obesity is not totally established. We have investi...

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Bibliographic Details
Main Authors: Gema Marín-Royo, Isabel Gallardo, Ernesto Martínez-Martínez, Beatriz Gutiérrez, Raquel Jurado-López, Natalia López-Andrés, Josué Gutiérrez-Tenorio, Eduardo Rial, Marı́a Visitación Bartolomé, María Luisa Nieto, Victoria Cachofeiro
Format: Article
Language:English
Published: The Company of Biologists 2018-02-01
Series:Disease Models & Mechanisms
Subjects:
Galectin-3
Insulin resistance
Lipotoxicity
Mitochondria
Obesity
Oxidative stress
Online Access:http://dmm.biologists.org/content/11/2/dmm032086

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