New advances of the androgen receptor in prostate cancer: report from the 1st International Androgen Receptor Symposium
Abstract The androgen receptor (AR) is a crucial player in various aspects of male reproduction and has been associated with the development and progression of prostate cancer (PCa). Therefore, the protein is the linchpin of current PCa therapies. Despite great research efforts, the AR signaling pat...
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-024-04878-5 |
| _version_ | 1797349697205043200 |
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| author | Sherif Mehralivand Christian Thomas Martin Puhr Frank Claessens Arjanneke F. van de Merbel Anna Dubrovska Guido Jenster Christof Bernemann Ulrich Sommer Holger H. H. Erb |
| author_facet | Sherif Mehralivand Christian Thomas Martin Puhr Frank Claessens Arjanneke F. van de Merbel Anna Dubrovska Guido Jenster Christof Bernemann Ulrich Sommer Holger H. H. Erb |
| author_sort | Sherif Mehralivand |
| collection | DOAJ |
| description | Abstract The androgen receptor (AR) is a crucial player in various aspects of male reproduction and has been associated with the development and progression of prostate cancer (PCa). Therefore, the protein is the linchpin of current PCa therapies. Despite great research efforts, the AR signaling pathway has still not been deciphered, and the emergence of resistance is still the biggest problem in PCa treatment. To discuss the latest developments in AR research, the “1st International Androgen Receptor Symposium” offered a forum for the exchange of clinical and scientific innovations around the role of the AR in prostate cancer (PCa) and to stimulate new collaborative interactions among leading scientists from basic, translational, and clinical research. The symposium included three sessions covering preclinical studies, prognostic and diagnostic biomarkers, and ongoing prostate cancer clinical trials. In addition, a panel discussion about the future direction of androgen deprivation therapy and anti-AR therapy in PCa was conducted. Therefore, the newest insights and developments in therapeutic strategies and biomarkers are discussed in this report. |
| first_indexed | 2024-03-08T12:34:08Z |
| format | Article |
| id | doaj.art-2100acb6c028487ea1592470d98b2707 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-03-08T12:34:08Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-2100acb6c028487ea1592470d98b27072024-01-21T12:33:08ZengBMCJournal of Translational Medicine1479-58762024-01-012211810.1186/s12967-024-04878-5New advances of the androgen receptor in prostate cancer: report from the 1st International Androgen Receptor SymposiumSherif Mehralivand0Christian Thomas1Martin Puhr2Frank Claessens3Arjanneke F. van de Merbel4Anna Dubrovska5Guido Jenster6Christof Bernemann7Ulrich Sommer8Holger H. H. Erb9Department of Urology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität DresdenDepartment of Urology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität DresdenDepartment of Urology, Medical University of InnsbruckMolecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU LeuvenDepartment of Urology, Leiden University Medical CenterOncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden-RossendorfDepartment of Urology, Erasmus MC Cancer Institute, University Medical CenterDepartment of Urology, University Hospital MuensterInstitut für Pathologie, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität DresdenDepartment of Urology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität DresdenAbstract The androgen receptor (AR) is a crucial player in various aspects of male reproduction and has been associated with the development and progression of prostate cancer (PCa). Therefore, the protein is the linchpin of current PCa therapies. Despite great research efforts, the AR signaling pathway has still not been deciphered, and the emergence of resistance is still the biggest problem in PCa treatment. To discuss the latest developments in AR research, the “1st International Androgen Receptor Symposium” offered a forum for the exchange of clinical and scientific innovations around the role of the AR in prostate cancer (PCa) and to stimulate new collaborative interactions among leading scientists from basic, translational, and clinical research. The symposium included three sessions covering preclinical studies, prognostic and diagnostic biomarkers, and ongoing prostate cancer clinical trials. In addition, a panel discussion about the future direction of androgen deprivation therapy and anti-AR therapy in PCa was conducted. Therefore, the newest insights and developments in therapeutic strategies and biomarkers are discussed in this report.https://doi.org/10.1186/s12967-024-04878-5Androgen receptorPCaNR3C4Androgen deprivation therapy |
| spellingShingle | Sherif Mehralivand Christian Thomas Martin Puhr Frank Claessens Arjanneke F. van de Merbel Anna Dubrovska Guido Jenster Christof Bernemann Ulrich Sommer Holger H. H. Erb New advances of the androgen receptor in prostate cancer: report from the 1st International Androgen Receptor Symposium Journal of Translational Medicine Androgen receptor PCa NR3C4 Androgen deprivation therapy |
| title | New advances of the androgen receptor in prostate cancer: report from the 1st International Androgen Receptor Symposium |
| title_full | New advances of the androgen receptor in prostate cancer: report from the 1st International Androgen Receptor Symposium |
| title_fullStr | New advances of the androgen receptor in prostate cancer: report from the 1st International Androgen Receptor Symposium |
| title_full_unstemmed | New advances of the androgen receptor in prostate cancer: report from the 1st International Androgen Receptor Symposium |
| title_short | New advances of the androgen receptor in prostate cancer: report from the 1st International Androgen Receptor Symposium |
| title_sort | new advances of the androgen receptor in prostate cancer report from the 1st international androgen receptor symposium |
| topic | Androgen receptor PCa NR3C4 Androgen deprivation therapy |
| url | https://doi.org/10.1186/s12967-024-04878-5 |
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