TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus
The role of TRPV1 in the CNS is not fully understood. Here the authors show that TRPV1 is expressed specifically in somatostatin-positive OLM interneurons of the hippocampus, where it promotes excitatory innervation of these cells.
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15878 |
| _version_ | 1818750458115653632 |
|---|---|
| author | Joaquin I. Hurtado-Zavala Binu Ramachandran Saheeb Ahmed Rashi Halder Christiane Bolleyer Ankit Awasthi Markus A. Stahlberg Robin J. Wagener Kristin Anderson Ryan M. Drenan Henry A. Lester Julie M. Miwa Jochen F. Staiger Andre Fischer Camin Dean |
| author_facet | Joaquin I. Hurtado-Zavala Binu Ramachandran Saheeb Ahmed Rashi Halder Christiane Bolleyer Ankit Awasthi Markus A. Stahlberg Robin J. Wagener Kristin Anderson Ryan M. Drenan Henry A. Lester Julie M. Miwa Jochen F. Staiger Andre Fischer Camin Dean |
| author_sort | Joaquin I. Hurtado-Zavala |
| collection | DOAJ |
| description | The role of TRPV1 in the CNS is not fully understood. Here the authors show that TRPV1 is expressed specifically in somatostatin-positive OLM interneurons of the hippocampus, where it promotes excitatory innervation of these cells. |
| first_indexed | 2024-12-18T04:19:59Z |
| format | Article |
| id | doaj.art-2105af867abe4a79822bee9ec7df90cb |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:19:59Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2105af867abe4a79822bee9ec7df90cb2022-12-21T21:21:15ZengNature PortfolioNature Communications2041-17232017-07-018112010.1038/ncomms15878TRPV1 regulates excitatory innervation of OLM neurons in the hippocampusJoaquin I. Hurtado-Zavala0Binu Ramachandran1Saheeb Ahmed2Rashi Halder3Christiane Bolleyer4Ankit Awasthi5Markus A. Stahlberg6Robin J. Wagener7Kristin Anderson8Ryan M. Drenan9Henry A. Lester10Julie M. Miwa11Jochen F. Staiger12Andre Fischer13Camin Dean14Trans-synaptic Signaling Group, European Neuroscience InstituteTrans-synaptic Signaling Group, European Neuroscience InstituteTrans-synaptic Signaling Group, European Neuroscience InstituteDepartment of Epigenetics and Systems Medicine in Neurodegenerative Disease, German Center for Neurodegenerative Disease, University Medical Center GoettingenTrans-synaptic Signaling Group, European Neuroscience InstituteTrans-synaptic Signaling Group, European Neuroscience InstituteTrans-synaptic Signaling Group, European Neuroscience InstituteInstitute for Neuroanatomy, University Medical Center GoettingenBiological Sciences Department, Lehigh UniversityDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue UniversityDivision of Biology and Biological Engineering, California Institute of TechnologyBiological Sciences Department, Lehigh UniversityInstitute for Neuroanatomy, University Medical Center GoettingenDepartment of Epigenetics and Systems Medicine in Neurodegenerative Disease, German Center for Neurodegenerative Disease, University Medical Center GoettingenTrans-synaptic Signaling Group, European Neuroscience InstituteThe role of TRPV1 in the CNS is not fully understood. Here the authors show that TRPV1 is expressed specifically in somatostatin-positive OLM interneurons of the hippocampus, where it promotes excitatory innervation of these cells.https://doi.org/10.1038/ncomms15878 |
| spellingShingle | Joaquin I. Hurtado-Zavala Binu Ramachandran Saheeb Ahmed Rashi Halder Christiane Bolleyer Ankit Awasthi Markus A. Stahlberg Robin J. Wagener Kristin Anderson Ryan M. Drenan Henry A. Lester Julie M. Miwa Jochen F. Staiger Andre Fischer Camin Dean TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus Nature Communications |
| title | TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus |
| title_full | TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus |
| title_fullStr | TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus |
| title_full_unstemmed | TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus |
| title_short | TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus |
| title_sort | trpv1 regulates excitatory innervation of olm neurons in the hippocampus |
| url | https://doi.org/10.1038/ncomms15878 |
| work_keys_str_mv | AT joaquinihurtadozavala trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus AT binuramachandran trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus AT saheebahmed trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus AT rashihalder trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus AT christianebolleyer trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus AT ankitawasthi trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus AT markusastahlberg trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus AT robinjwagener trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus AT kristinanderson trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus AT ryanmdrenan trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus AT henryalester trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus AT juliemmiwa trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus AT jochenfstaiger trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus AT andrefischer trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus AT camindean trpv1regulatesexcitatoryinnervationofolmneuronsinthehippocampus |