A Rare Case of Mixed Infectious Keratitis Caused by Pseudomonas koreensis and Aspergillus fumigatus
We report the clinical and microbiological features of contact lens-related mixed infectious keratitis caused by a spore-forming filamentous fungus and a rare gram-negative bacterial infection. A 66-year-old Caucasian female presented with right eye (OD) pain after sleeping in her 2-weekly contact l...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2020-11-01
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| Series: | Case Reports in Ophthalmology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/510571 |
| _version_ | 1818922290268602368 |
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| author | Lin Wei Khoo Sathish S. Srinivasan Fiona L. Henriquez Abhijit M. Bal |
| author_facet | Lin Wei Khoo Sathish S. Srinivasan Fiona L. Henriquez Abhijit M. Bal |
| author_sort | Lin Wei Khoo |
| collection | DOAJ |
| description | We report the clinical and microbiological features of contact lens-related mixed infectious keratitis caused by a spore-forming filamentous fungus and a rare gram-negative bacterial infection. A 66-year-old Caucasian female presented with right eye (OD) pain after sleeping in her 2-weekly contact lenses for 3 days. On presentation, corrected distance visual acuity was 0.46 LogMAR OD and 0.20 in the left eye. Slit lamp biomicroscopy revealed a 1.9 mm by 1.9 mm area of dense stromal infiltrate with epithelial defect. Corneal scrapes grew Aspergillus fumigatus and Pseudomonas koreensis, and culture-directed microbial therapy with oral and topical voriconazole and topical fortified gentamicin along with regular debridement resulted in slow resolution of the infection, leaving a dense stromal scar in the visual axis requiring penetrating keratoplasty. Mixed infectious keratitis caused by filamentous fungi and gram-negative bacteria is rare. Pseudomonas koreensis infection has not been previously reported as a cause of infectious keratitis in humans. In our experience, these mixed infections require prolonged systemic and topical therapy and the secondary scarring may require surgical intervention for vision rehabilitation. |
| first_indexed | 2024-12-20T01:51:11Z |
| format | Article |
| id | doaj.art-2106cd6ecb2f41c781089c79e11c5b34 |
| institution | Directory Open Access Journal |
| issn | 1663-2699 |
| language | English |
| last_indexed | 2024-12-20T01:51:11Z |
| publishDate | 2020-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Ophthalmology |
| spelling | doaj.art-2106cd6ecb2f41c781089c79e11c5b342022-12-21T19:57:37ZengKarger PublishersCase Reports in Ophthalmology1663-26992020-11-0111360060510.1159/000510571510571A Rare Case of Mixed Infectious Keratitis Caused by Pseudomonas koreensis and Aspergillus fumigatusLin Wei KhooSathish S. SrinivasanFiona L. HenriquezAbhijit M. BalWe report the clinical and microbiological features of contact lens-related mixed infectious keratitis caused by a spore-forming filamentous fungus and a rare gram-negative bacterial infection. A 66-year-old Caucasian female presented with right eye (OD) pain after sleeping in her 2-weekly contact lenses for 3 days. On presentation, corrected distance visual acuity was 0.46 LogMAR OD and 0.20 in the left eye. Slit lamp biomicroscopy revealed a 1.9 mm by 1.9 mm area of dense stromal infiltrate with epithelial defect. Corneal scrapes grew Aspergillus fumigatus and Pseudomonas koreensis, and culture-directed microbial therapy with oral and topical voriconazole and topical fortified gentamicin along with regular debridement resulted in slow resolution of the infection, leaving a dense stromal scar in the visual axis requiring penetrating keratoplasty. Mixed infectious keratitis caused by filamentous fungi and gram-negative bacteria is rare. Pseudomonas koreensis infection has not been previously reported as a cause of infectious keratitis in humans. In our experience, these mixed infections require prolonged systemic and topical therapy and the secondary scarring may require surgical intervention for vision rehabilitation.https://www.karger.com/Article/FullText/510571mixed infectious keratitisinfectious keratitisgram-negative bacteriabacteriafungus |
| spellingShingle | Lin Wei Khoo Sathish S. Srinivasan Fiona L. Henriquez Abhijit M. Bal A Rare Case of Mixed Infectious Keratitis Caused by Pseudomonas koreensis and Aspergillus fumigatus Case Reports in Ophthalmology mixed infectious keratitis infectious keratitis gram-negative bacteria bacteria fungus |
| title | A Rare Case of Mixed Infectious Keratitis Caused by Pseudomonas koreensis and Aspergillus fumigatus |
| title_full | A Rare Case of Mixed Infectious Keratitis Caused by Pseudomonas koreensis and Aspergillus fumigatus |
| title_fullStr | A Rare Case of Mixed Infectious Keratitis Caused by Pseudomonas koreensis and Aspergillus fumigatus |
| title_full_unstemmed | A Rare Case of Mixed Infectious Keratitis Caused by Pseudomonas koreensis and Aspergillus fumigatus |
| title_short | A Rare Case of Mixed Infectious Keratitis Caused by Pseudomonas koreensis and Aspergillus fumigatus |
| title_sort | rare case of mixed infectious keratitis caused by pseudomonas koreensis and aspergillus fumigatus |
| topic | mixed infectious keratitis infectious keratitis gram-negative bacteria bacteria fungus |
| url | https://www.karger.com/Article/FullText/510571 |
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