Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery

Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery

Abstract Heat shock protein 90 (Hsp90) is a critical molecular chaperone protein that regulates the folding, maturation, and stability of a wide variety of proteins. In recent years, the development of Hsp90-directed inhibitors has grown rapidly, and many of these inhibitors have entered clinical tr...

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Bibliographic Details
Main Authors: Ting Li, Hu-Lin Jiang, Yun-Guang Tong, Jin-Jian Lu
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Hematology & Oncology
Subjects:
Hsp90 chaperone machinery
Cdc37
Kinase client
Protein interaction
Online Access:http://link.springer.com/article/10.1186/s13045-018-0602-8

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