Biocellulose for Incisional Hernia Repair—An Experimental Pilot Study
Ventral or incisional hernia are a common disease pattern in general surgery. Most commonly, a mesh repair is used for reconstruction, whereby the mesh itself might cause complications, like infections or adhesions. Biological materials, like biocellulose, might reduce these clinical problems substa...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-02-01
|
| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/9/2/236 |
| _version_ | 1811293995296358400 |
|---|---|
| author | Falk Rauchfuß Julian Helble Johanna Bruns Olaf Dirsch Uta Dahmen Michael Ardelt Utz Settmacher Hubert Scheuerlein |
| author_facet | Falk Rauchfuß Julian Helble Johanna Bruns Olaf Dirsch Uta Dahmen Michael Ardelt Utz Settmacher Hubert Scheuerlein |
| author_sort | Falk Rauchfuß |
| collection | DOAJ |
| description | Ventral or incisional hernia are a common disease pattern in general surgery. Most commonly, a mesh repair is used for reconstruction, whereby the mesh itself might cause complications, like infections or adhesions. Biological materials, like biocellulose, might reduce these clinical problems substantially. In this prospective rodent study, a biocellulose mesh (produced by Gluconacetobacter xylinus) was implanted either by a sublay technique or as supplementation of the abdominal wall. After an observation period of 90 days, animals were sacrificed. The adhesions after the reconstruction of the abdominal wall were moderate. The histologic investigations revealed that the biocellulose itself was inert, with a minimal regenerative response surrounding the mesh. The explanted mesh showed a minimal shrinkage (around 15%) as well as a minimal loss of tear-out force, which might be without clinical relevance. This is the first in vivo study describing biocellulose as a suitable mesh for the repair of ventral hernia in two different hernia models. The material seems to be a promising option for solving actual problems in modern hernia surgery. |
| first_indexed | 2024-04-13T05:10:42Z |
| format | Article |
| id | doaj.art-210b1699e42444539317bb0946923b89 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-04-13T05:10:42Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-210b1699e42444539317bb0946923b892022-12-22T03:01:02ZengMDPI AGNanomaterials2079-49912019-02-019223610.3390/nano9020236nano9020236Biocellulose for Incisional Hernia Repair—An Experimental Pilot StudyFalk Rauchfuß0Julian Helble1Johanna Bruns2Olaf Dirsch3Uta Dahmen4Michael Ardelt5Utz Settmacher6Hubert Scheuerlein7Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, GermanyDepartment of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, GermanyDepartment of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, GermanyExperimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, GermanyExperimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, GermanyDepartment of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, GermanyDepartment of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, GermanyDepartment of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, GermanyVentral or incisional hernia are a common disease pattern in general surgery. Most commonly, a mesh repair is used for reconstruction, whereby the mesh itself might cause complications, like infections or adhesions. Biological materials, like biocellulose, might reduce these clinical problems substantially. In this prospective rodent study, a biocellulose mesh (produced by Gluconacetobacter xylinus) was implanted either by a sublay technique or as supplementation of the abdominal wall. After an observation period of 90 days, animals were sacrificed. The adhesions after the reconstruction of the abdominal wall were moderate. The histologic investigations revealed that the biocellulose itself was inert, with a minimal regenerative response surrounding the mesh. The explanted mesh showed a minimal shrinkage (around 15%) as well as a minimal loss of tear-out force, which might be without clinical relevance. This is the first in vivo study describing biocellulose as a suitable mesh for the repair of ventral hernia in two different hernia models. The material seems to be a promising option for solving actual problems in modern hernia surgery.https://www.mdpi.com/2079-4991/9/2/236meshmesh infectionabdominal wallreconstruction |
| spellingShingle | Falk Rauchfuß Julian Helble Johanna Bruns Olaf Dirsch Uta Dahmen Michael Ardelt Utz Settmacher Hubert Scheuerlein Biocellulose for Incisional Hernia Repair—An Experimental Pilot Study Nanomaterials mesh mesh infection abdominal wall reconstruction |
| title | Biocellulose for Incisional Hernia Repair—An Experimental Pilot Study |
| title_full | Biocellulose for Incisional Hernia Repair—An Experimental Pilot Study |
| title_fullStr | Biocellulose for Incisional Hernia Repair—An Experimental Pilot Study |
| title_full_unstemmed | Biocellulose for Incisional Hernia Repair—An Experimental Pilot Study |
| title_short | Biocellulose for Incisional Hernia Repair—An Experimental Pilot Study |
| title_sort | biocellulose for incisional hernia repair an experimental pilot study |
| topic | mesh mesh infection abdominal wall reconstruction |
| url | https://www.mdpi.com/2079-4991/9/2/236 |
| work_keys_str_mv | AT falkrauchfuß biocelluloseforincisionalherniarepairanexperimentalpilotstudy AT julianhelble biocelluloseforincisionalherniarepairanexperimentalpilotstudy AT johannabruns biocelluloseforincisionalherniarepairanexperimentalpilotstudy AT olafdirsch biocelluloseforincisionalherniarepairanexperimentalpilotstudy AT utadahmen biocelluloseforincisionalherniarepairanexperimentalpilotstudy AT michaelardelt biocelluloseforincisionalherniarepairanexperimentalpilotstudy AT utzsettmacher biocelluloseforincisionalherniarepairanexperimentalpilotstudy AT hubertscheuerlein biocelluloseforincisionalherniarepairanexperimentalpilotstudy |