Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx
Aims. The objective of this study was to compare bone invasion type with histopathological, clinical and immunohistochemical prognostic factors. Methods. The study included 49 patients who were treated for oral squamous cell carcinoma. Of which, 30 patients, with presence of bone invasion on histopa...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Palacký University Olomouc, Faculty of Medicine and Dentistry
2023-06-01
|
| Series: | Biomedical Papers |
| Subjects: | |
| Online Access: | https://biomed.papers.upol.cz/artkey/bio-202302-0006_importance-of-evaluation-of-bone-invasion-type-in-squamous-cell-carcinomas-of-the-oral-cavity-and-oropharynx.php |
| _version_ | 1797804244556840960 |
|---|---|
| author | Richard Pink Jaroslav Michalek David Kral Michal Mozola Pavel Benes Saskova Lenka Zdenek Dvorak |
| author_facet | Richard Pink Jaroslav Michalek David Kral Michal Mozola Pavel Benes Saskova Lenka Zdenek Dvorak |
| author_sort | Richard Pink |
| collection | DOAJ |
| description | Aims. The objective of this study was to compare bone invasion type with histopathological, clinical and immunohistochemical prognostic factors. Methods. The study included 49 patients who were treated for oral squamous cell carcinoma. Of which, 30 patients, with presence of bone invasion on histopathology, were divided according to the type of bone invasion (erosive, infiltrative, mixed). Each invasion type was compared to microvascular density using the CD34 marker. Results. The bone invasion was observed in 30 out of 49 patients (61.22%). On McNemar's test, statistically significant association was observed between bone invasion types and histopathological grade. In contrast, no significant correlation was observed between bone invasion type, and tumour volume or nodal metastases. In tumours with bone invasion of the infiltrative type, higher frequency of locoregional relapses was observed. The 5-year survival, since diagnosis, was approximately 60% in the erosive group, 40% in the mixed group, and merely 15% in the infiltrative group. Conclusion. Peritumoural microvascular density was not significantly related to bone invasion types. Whereas, a significantly higher intratumoural microvascular density was observed in infiltrative type of the bone invasion, when compared to the erosive and mixed type. |
| first_indexed | 2024-03-13T05:34:14Z |
| format | Article |
| id | doaj.art-210b73504ba44a1daa54b6b26dad56c3 |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-03-13T05:34:14Z |
| publishDate | 2023-06-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-210b73504ba44a1daa54b6b26dad56c32023-06-14T11:15:48ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212023-06-01167213914410.5507/bp.2021.062bio-202302-0006Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynxRichard Pink0Jaroslav Michalek1David Kral2Michal Mozola3Pavel Benes4Saskova Lenka5Zdenek Dvorak6Department of Oral and Maxillofacial Surgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Clinical and Molecular Pathology, University Hospital Olomouc, Czech RepublicDepartment of Oral and Maxillofacial Surgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Oral and Maxillofacial Surgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Oral and Maxillofacial Surgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Oral and Maxillofacial Surgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Oral and Maxillofacial Surgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicAims. The objective of this study was to compare bone invasion type with histopathological, clinical and immunohistochemical prognostic factors. Methods. The study included 49 patients who were treated for oral squamous cell carcinoma. Of which, 30 patients, with presence of bone invasion on histopathology, were divided according to the type of bone invasion (erosive, infiltrative, mixed). Each invasion type was compared to microvascular density using the CD34 marker. Results. The bone invasion was observed in 30 out of 49 patients (61.22%). On McNemar's test, statistically significant association was observed between bone invasion types and histopathological grade. In contrast, no significant correlation was observed between bone invasion type, and tumour volume or nodal metastases. In tumours with bone invasion of the infiltrative type, higher frequency of locoregional relapses was observed. The 5-year survival, since diagnosis, was approximately 60% in the erosive group, 40% in the mixed group, and merely 15% in the infiltrative group. Conclusion. Peritumoural microvascular density was not significantly related to bone invasion types. Whereas, a significantly higher intratumoural microvascular density was observed in infiltrative type of the bone invasion, when compared to the erosive and mixed type.https://biomed.papers.upol.cz/artkey/bio-202302-0006_importance-of-evaluation-of-bone-invasion-type-in-squamous-cell-carcinomas-of-the-oral-cavity-and-oropharynx.phporal squamous cell carcinoma of head and neckneoplasm invasivenesshead and neck neoplasmsmaxillofacial surgerytumor gradingneoplasm staginghistocytochemistry |
| spellingShingle | Richard Pink Jaroslav Michalek David Kral Michal Mozola Pavel Benes Saskova Lenka Zdenek Dvorak Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx Biomedical Papers oral squamous cell carcinoma of head and neck neoplasm invasiveness head and neck neoplasms maxillofacial surgery tumor grading neoplasm staging histocytochemistry |
| title | Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx |
| title_full | Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx |
| title_fullStr | Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx |
| title_full_unstemmed | Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx |
| title_short | Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx |
| title_sort | importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx |
| topic | oral squamous cell carcinoma of head and neck neoplasm invasiveness head and neck neoplasms maxillofacial surgery tumor grading neoplasm staging histocytochemistry |
| url | https://biomed.papers.upol.cz/artkey/bio-202302-0006_importance-of-evaluation-of-bone-invasion-type-in-squamous-cell-carcinomas-of-the-oral-cavity-and-oropharynx.php |
| work_keys_str_mv | AT richardpink importanceofevaluationofboneinvasiontypeinsquamouscellcarcinomasoftheoralcavityandoropharynx AT jaroslavmichalek importanceofevaluationofboneinvasiontypeinsquamouscellcarcinomasoftheoralcavityandoropharynx AT davidkral importanceofevaluationofboneinvasiontypeinsquamouscellcarcinomasoftheoralcavityandoropharynx AT michalmozola importanceofevaluationofboneinvasiontypeinsquamouscellcarcinomasoftheoralcavityandoropharynx AT pavelbenes importanceofevaluationofboneinvasiontypeinsquamouscellcarcinomasoftheoralcavityandoropharynx AT saskovalenka importanceofevaluationofboneinvasiontypeinsquamouscellcarcinomasoftheoralcavityandoropharynx AT zdenekdvorak importanceofevaluationofboneinvasiontypeinsquamouscellcarcinomasoftheoralcavityandoropharynx |