Is there any effect of insulin resistance on male reproductive system?
Objectives: To investigate the possible effect of insulin resistance (IR) on male reproductive system via evaluation of semen analysis, male sex hormones and serum lipid profiles, and testicular volumes. Methods: After the exclusions, a total of 80 male patients were enrolled in this prospective stu...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2014-03-01
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| Series: | Archivio Italiano di Urologia e Andrologia |
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| Online Access: | http://www.pagepressjournals.org/index.php/aiua/article/view/3302 |
| _version_ | 1818511598206058496 |
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| author | Ayhan Verit Fatma Ferda Verit Halil Oncel Halil Ciftci |
| author_facet | Ayhan Verit Fatma Ferda Verit Halil Oncel Halil Ciftci |
| author_sort | Ayhan Verit |
| collection | DOAJ |
| description | Objectives: To investigate the possible effect of insulin resistance (IR) on male reproductive system via evaluation of semen analysis, male sex hormones and serum lipid profiles, and testicular volumes. Methods: After the exclusions, a total of 80 male patients were enrolled in this prospective study. Body Mass Index (BMI), Testicular volume, semen samples, serum hormone/lipid profiles, high sensitive C-Reactive Protein (hsCRP) were obtained from all the subjects. Results: The patients were divided into two groups as study and control according to the presence of IR. There were no statistical differences in terms of age, marriage period, testicular volume, serum levels of hormone and lipid profiles and BMI between the groups. There were no relationship between homeostasis model assessment of insulin resistance (HOMA-IR) and semen volume (r = -0.10, p = 0.37), total sperm count (r = -0.09, p = 0.39), motility (r = -0.15, p = 0.16) and morphology (r = -0.14, p = 0.19). However, HOMA-IR was closely associated with hsCRP levels (r = 0.94, p < 0.0001). Conclusions: Despite of the documented strong inverse relationships between Diabetes Mellitus (DM) and male/female fertility, and also between IR and female infertility via ovarian functions as in polycystic ovary syndrome, to our knowledge, there is no report about any influence of IR on male fertility. DM and metabolic syndrome (MetS) have negative influence on fertility. Thus, IR may be accused of causing detrimental effect on male infertility due to hyperinsulinemic state and being one of the components for MetS. Interestingly, due to our preliminary results, we do not found any inverse correlation between IR and male reproductive functions. |
| first_indexed | 2024-12-10T23:35:17Z |
| format | Article |
| id | doaj.art-210c0655fca94cb8ad8b11494a1334bc |
| institution | Directory Open Access Journal |
| issn | 1124-3562 2282-4197 |
| language | English |
| last_indexed | 2024-12-10T23:35:17Z |
| publishDate | 2014-03-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Archivio Italiano di Urologia e Andrologia |
| spelling | doaj.art-210c0655fca94cb8ad8b11494a1334bc2022-12-22T01:29:13ZengPAGEPress PublicationsArchivio Italiano di Urologia e Andrologia1124-35622282-41972014-03-018615810.4081/aiua.2014.1.52559Is there any effect of insulin resistance on male reproductive system?Ayhan Verit0Fatma Ferda Verit1Halil Oncel2Halil Ciftci3Fatih Sultan Mehmet Research & Training Hospital, Dept. of Urology, IstanbulSuleymaniye Maternity, Research & Training Hospital, Dept. of Obstetrics & Gynaecology, Infertility Research & Treatment Centre, IstanbulSanliurfa Research & Training Hospital, Dept. of Urology, SanliurfaHarran University, School of Medicine, Dept. of Urology, SanliurfaObjectives: To investigate the possible effect of insulin resistance (IR) on male reproductive system via evaluation of semen analysis, male sex hormones and serum lipid profiles, and testicular volumes. Methods: After the exclusions, a total of 80 male patients were enrolled in this prospective study. Body Mass Index (BMI), Testicular volume, semen samples, serum hormone/lipid profiles, high sensitive C-Reactive Protein (hsCRP) were obtained from all the subjects. Results: The patients were divided into two groups as study and control according to the presence of IR. There were no statistical differences in terms of age, marriage period, testicular volume, serum levels of hormone and lipid profiles and BMI between the groups. There were no relationship between homeostasis model assessment of insulin resistance (HOMA-IR) and semen volume (r = -0.10, p = 0.37), total sperm count (r = -0.09, p = 0.39), motility (r = -0.15, p = 0.16) and morphology (r = -0.14, p = 0.19). However, HOMA-IR was closely associated with hsCRP levels (r = 0.94, p < 0.0001). Conclusions: Despite of the documented strong inverse relationships between Diabetes Mellitus (DM) and male/female fertility, and also between IR and female infertility via ovarian functions as in polycystic ovary syndrome, to our knowledge, there is no report about any influence of IR on male fertility. DM and metabolic syndrome (MetS) have negative influence on fertility. Thus, IR may be accused of causing detrimental effect on male infertility due to hyperinsulinemic state and being one of the components for MetS. Interestingly, due to our preliminary results, we do not found any inverse correlation between IR and male reproductive functions.http://www.pagepressjournals.org/index.php/aiua/article/view/3302Insulin resistanceMale reproductive systemMale fertilitySex hormonessperm |
| spellingShingle | Ayhan Verit Fatma Ferda Verit Halil Oncel Halil Ciftci Is there any effect of insulin resistance on male reproductive system? Archivio Italiano di Urologia e Andrologia Insulin resistance Male reproductive system Male fertility Sex hormones sperm |
| title | Is there any effect of insulin resistance on male reproductive system? |
| title_full | Is there any effect of insulin resistance on male reproductive system? |
| title_fullStr | Is there any effect of insulin resistance on male reproductive system? |
| title_full_unstemmed | Is there any effect of insulin resistance on male reproductive system? |
| title_short | Is there any effect of insulin resistance on male reproductive system? |
| title_sort | is there any effect of insulin resistance on male reproductive system |
| topic | Insulin resistance Male reproductive system Male fertility Sex hormones sperm |
| url | http://www.pagepressjournals.org/index.php/aiua/article/view/3302 |
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