Change in the activity of angiotensin-converting enzyme in pneumonia and chronic obstructive lung diseases
Aim. To study the activity of angiotensin-converting enzyme (ACE) in patients with pneumonia and chronic obstructive lung diseases (COLD). Material and Methods. Sixty nine patients with pneumonia and 77 with COLD were examined. The activity of ACE in the serum and bronchoalveolar lavage (BAL) and th...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2003-03-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/29338 |
| _version_ | 1819013302309617664 |
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| author | B Yu Altshuler A P Roitman T A Fedorova V G Novazhenov S A Belkov M N Gordeev G A Yarovaya Ye A Neshkova A A Ustinov |
| author_facet | B Yu Altshuler A P Roitman T A Fedorova V G Novazhenov S A Belkov M N Gordeev G A Yarovaya Ye A Neshkova A A Ustinov |
| author_sort | B Yu Altshuler |
| collection | DOAJ |
| description | Aim. To study the activity of angiotensin-converting enzyme (ACE) in patients with pneumonia and chronic obstructive lung diseases (COLD).
Material and Methods. Sixty nine patients with pneumonia and 77 with COLD were examined. The activity of ACE in the serum and bronchoalveolar lavage (BAL) and the effects of leukocytic elastase and concentrations of zinc, endogenous inhibitors, and activators were studied. Results. The patients with pneumonia in the acute phase of the disease have been found to have low ACE activity in both blood and BAL. As the inflammatory process comes to an end, ACE activity normalizes. In the patients with COLD, the activity of ACE is primarily decreased at remission. When COLD aggravates, the activity of ACE in blood and BAL increases. In pneumonia and COLD, the changes in ACE activity are more profound in BAL than in blood.
Conclusion. The only cause of the altered activity of ACE in patients with COLD and pneumonia is a change in the concentration of the enzyme. |
| first_indexed | 2024-12-21T01:57:47Z |
| format | Article |
| id | doaj.art-210cf41fdd504abe837dc4bad91868da |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-21T01:57:47Z |
| publishDate | 2003-03-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-210cf41fdd504abe837dc4bad91868da2022-12-21T19:19:42Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422003-03-0178326374Change in the activity of angiotensin-converting enzyme in pneumonia and chronic obstructive lung diseasesB Yu AltshulerA P RoitmanT A FedorovaV G NovazhenovS A BelkovM N GordeevG A YarovayaYe A NeshkovaA A UstinovAim. To study the activity of angiotensin-converting enzyme (ACE) in patients with pneumonia and chronic obstructive lung diseases (COLD). Material and Methods. Sixty nine patients with pneumonia and 77 with COLD were examined. The activity of ACE in the serum and bronchoalveolar lavage (BAL) and the effects of leukocytic elastase and concentrations of zinc, endogenous inhibitors, and activators were studied. Results. The patients with pneumonia in the acute phase of the disease have been found to have low ACE activity in both blood and BAL. As the inflammatory process comes to an end, ACE activity normalizes. In the patients with COLD, the activity of ACE is primarily decreased at remission. When COLD aggravates, the activity of ACE in blood and BAL increases. In pneumonia and COLD, the changes in ACE activity are more profound in BAL than in blood. Conclusion. The only cause of the altered activity of ACE in patients with COLD and pneumonia is a change in the concentration of the enzyme.https://ter-arkhiv.ru/0040-3660/article/view/29338angiotensin-converting enzymechronic obstructive lung diseasespneumoniaarterial hypotensionarterial hypertensionleukocytic elastasezincinhibitors |
| spellingShingle | B Yu Altshuler A P Roitman T A Fedorova V G Novazhenov S A Belkov M N Gordeev G A Yarovaya Ye A Neshkova A A Ustinov Change in the activity of angiotensin-converting enzyme in pneumonia and chronic obstructive lung diseases Терапевтический архив angiotensin-converting enzyme chronic obstructive lung diseases pneumonia arterial hypotension arterial hypertension leukocytic elastase zinc inhibitors |
| title | Change in the activity of angiotensin-converting enzyme in pneumonia and chronic obstructive lung diseases |
| title_full | Change in the activity of angiotensin-converting enzyme in pneumonia and chronic obstructive lung diseases |
| title_fullStr | Change in the activity of angiotensin-converting enzyme in pneumonia and chronic obstructive lung diseases |
| title_full_unstemmed | Change in the activity of angiotensin-converting enzyme in pneumonia and chronic obstructive lung diseases |
| title_short | Change in the activity of angiotensin-converting enzyme in pneumonia and chronic obstructive lung diseases |
| title_sort | change in the activity of angiotensin converting enzyme in pneumonia and chronic obstructive lung diseases |
| topic | angiotensin-converting enzyme chronic obstructive lung diseases pneumonia arterial hypotension arterial hypertension leukocytic elastase zinc inhibitors |
| url | https://ter-arkhiv.ru/0040-3660/article/view/29338 |
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