Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis
There is growing interest in single nucleotide polymorphisms (SNPs) in the genes of microRNAs (miRNAs), which could be associated with susceptibility to colorectal cancer (CRC) and therefore for prognosis of the disease and/or treatment response. Moreover, these miRNAs-SNPs could serve as new, low-i...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/1/156 |
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| author | Maria Radanova Mariya Levkova Galya Mihaylova Rostislav Manev Margarita Maneva Rossen Hadgiev Nikolay Conev Ivan Donev |
| author_facet | Maria Radanova Mariya Levkova Galya Mihaylova Rostislav Manev Margarita Maneva Rossen Hadgiev Nikolay Conev Ivan Donev |
| author_sort | Maria Radanova |
| collection | DOAJ |
| description | There is growing interest in single nucleotide polymorphisms (SNPs) in the genes of microRNAs (miRNAs), which could be associated with susceptibility to colorectal cancer (CRC) and therefore for prognosis of the disease and/or treatment response. Moreover, these miRNAs-SNPs could serve as new, low-invasive biomarkers for early detection of CRC. In the present article, we performed a thorough review of different SNPs, which were investigated for a correlation with the CRC risk, prognosis, and treatment response. We also analyzed the results from different meta-analyses and the possible reasons for reported contradictory findings, especially when different research groups investigated the same SNP in a gene for a particular miRNA. This illustrates the need for more case-control studies involving participants with different ethnic backgrounds. According to our review, three miRNAs-SNPs—miR-146a rs2910164, miR-27a rs895819 and miR-608 rs4919510—appear as promising prognostic, diagnostic and predictive biomarkers for CRC, respectively. |
| first_indexed | 2024-03-10T01:50:43Z |
| format | Article |
| id | doaj.art-210d4a5d64df470cb25a3f04f021fffb |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T01:50:43Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-210d4a5d64df470cb25a3f04f021fffb2023-11-23T13:04:44ZengMDPI AGBiomedicines2227-90592022-01-0110115610.3390/biomedicines10010156Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and PrognosisMaria Radanova0Mariya Levkova1Galya Mihaylova2Rostislav Manev3Margarita Maneva4Rossen Hadgiev5Nikolay Conev6Ivan Donev7Department of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, 9000 Varna, BulgariaDepartment of Medical Genetics, Medical University of Varna, 9000 Varna, BulgariaDepartment of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, 9000 Varna, BulgariaDepartment of Oncology, Medical University of Varna, 9000 Varna, BulgariaDepartment of Oncology, Medical University of Varna, 9000 Varna, BulgariaDepartment of Anatomy and Histology, Pathology and Forensic Medicine, Sofia University “St. Kliment Ohridski”, 1000 Sofia, BulgariaDepartment of Oncology, Medical University of Varna, 9000 Varna, BulgariaClinic of Medical Oncology, Hospital “Nadezhda”, 1000 Sofia, BulgariaThere is growing interest in single nucleotide polymorphisms (SNPs) in the genes of microRNAs (miRNAs), which could be associated with susceptibility to colorectal cancer (CRC) and therefore for prognosis of the disease and/or treatment response. Moreover, these miRNAs-SNPs could serve as new, low-invasive biomarkers for early detection of CRC. In the present article, we performed a thorough review of different SNPs, which were investigated for a correlation with the CRC risk, prognosis, and treatment response. We also analyzed the results from different meta-analyses and the possible reasons for reported contradictory findings, especially when different research groups investigated the same SNP in a gene for a particular miRNA. This illustrates the need for more case-control studies involving participants with different ethnic backgrounds. According to our review, three miRNAs-SNPs—miR-146a rs2910164, miR-27a rs895819 and miR-608 rs4919510—appear as promising prognostic, diagnostic and predictive biomarkers for CRC, respectively.https://www.mdpi.com/2227-9059/10/1/156single nucleotide polymorphismSNPmiRNAcolorectal cancer |
| spellingShingle | Maria Radanova Mariya Levkova Galya Mihaylova Rostislav Manev Margarita Maneva Rossen Hadgiev Nikolay Conev Ivan Donev Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis Biomedicines single nucleotide polymorphism SNP miRNA colorectal cancer |
| title | Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis |
| title_full | Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis |
| title_fullStr | Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis |
| title_full_unstemmed | Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis |
| title_short | Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis |
| title_sort | single nucleotide polymorphisms in microrna genes and colorectal cancer risk and prognosis |
| topic | single nucleotide polymorphism SNP miRNA colorectal cancer |
| url | https://www.mdpi.com/2227-9059/10/1/156 |
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