Adherence to prenatal iron-folic acid supplementation in low- and middle-income countries (LMIC): a protocol for systematic review and meta-analysis
Abstract Background Daily iron-folic acid supplementation reduces anemia and various adverse obstetric outcomes such as preterm delivery, low birthweight, hemorrhage, and perinatal and maternal morbidity and mortality. However, its supplementation has not been successful that attributed to several d...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | Systematic Reviews |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13643-018-0774-x |
| _version_ | 1819039417235406848 |
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| author | Mohammed Akibu Tesfalidet Tekelab Abdella Amano Merga Besho Stephanie Grutzmacher Mesfin Tadese Tesfa Dejenie Habtewold |
| author_facet | Mohammed Akibu Tesfalidet Tekelab Abdella Amano Merga Besho Stephanie Grutzmacher Mesfin Tadese Tesfa Dejenie Habtewold |
| author_sort | Mohammed Akibu |
| collection | DOAJ |
| description | Abstract Background Daily iron-folic acid supplementation reduces anemia and various adverse obstetric outcomes such as preterm delivery, low birthweight, hemorrhage, and perinatal and maternal morbidity and mortality. However, its supplementation has not been successful that attributed to several determinants including poor adherence. Therefore, we aimed to conduct a systematic review and meta-analysis on the prevalence and determinants of adherence to prenatal iron-folic acid supplementation in low- and middle-income countries. In addition, we will develop a conceptual framework in the context of low- and middle-income countries (LMIC). Methods/design We will search PubMed, MEDLINE, EMBASE, EBSCO, Web of Science, SCOPUS, WHO Global Index Medicus, and African Journals Online (AJOL) databases to retrieve relevant literatures. Observational (i.e., case-control, cohort, cross-sectional, survey, and surveillance reports) and quasi-randomized and randomized controlled trial studies conducted in LMIC will be included. The Newcastle-Ottawa Scale (NOS) and Joanna Briggs Institute (JBI) critical appraisal checklist will be used to assess the quality of observational and randomized controlled trial studies respectively. The pooled prevalence and odds ratio of determinants of adherence will be generated using a weighted inverse-variance meta-analysis model. Statistical heterogeneity among studies will be assessed by Cochran’s Q χ 2 statistics and Higgins (I 2 statistics) method. The result will be presented using forest plots and Harvest plots when necessary. Furthermore, we will perform Jackknife sensitivity and subgroup analysis. Data will be analyzed using comprehensive meta-analysis software (version 2). Discussion Contemporary evidence about the prevalence and determinants of adherence in LMIC will be synthesized to generate up-to-date knowledge. To our knowledge, this is the first systematic review. It would have substantial implications for researchers, clinicians, and policymakers for optimizing maternal and child health outcomes in LMIC. Systematic review registration The protocol has been registered on International Prospective Register of Systematic Review (PROSPERO), University of York Center for Reviews and Dissemination (https://www.crd.york.ac.uk/), registration number CRD42017080245. |
| first_indexed | 2024-12-21T08:52:52Z |
| format | Article |
| id | doaj.art-210d74dddf464f2bbaac704854f69202 |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-12-21T08:52:52Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-210d74dddf464f2bbaac704854f692022022-12-21T19:09:37ZengBMCSystematic Reviews2046-40532018-07-01711510.1186/s13643-018-0774-xAdherence to prenatal iron-folic acid supplementation in low- and middle-income countries (LMIC): a protocol for systematic review and meta-analysisMohammed Akibu0Tesfalidet Tekelab1Abdella Amano2Merga Besho3Stephanie Grutzmacher4Mesfin Tadese5Tesfa Dejenie Habtewold6Institute of Medicine and Health Science, Debre Berhan UniversityResearch Centre for Generational Health and Ageing at the Hunter Medical Research Institute, University of NewcastleCollege of Medicine and Health Science, School of Public Health, Hawassa UniversityCollege of Medicine and Health Science, Wollaga UniversitySchool of Biological and Population Health Sciences, Oregon State UniversityInstitute of Medicine and Health Science, Debre Berhan UniversityDepartment of Epidemiology, University Medical Center Groningen, University of GroningenAbstract Background Daily iron-folic acid supplementation reduces anemia and various adverse obstetric outcomes such as preterm delivery, low birthweight, hemorrhage, and perinatal and maternal morbidity and mortality. However, its supplementation has not been successful that attributed to several determinants including poor adherence. Therefore, we aimed to conduct a systematic review and meta-analysis on the prevalence and determinants of adherence to prenatal iron-folic acid supplementation in low- and middle-income countries. In addition, we will develop a conceptual framework in the context of low- and middle-income countries (LMIC). Methods/design We will search PubMed, MEDLINE, EMBASE, EBSCO, Web of Science, SCOPUS, WHO Global Index Medicus, and African Journals Online (AJOL) databases to retrieve relevant literatures. Observational (i.e., case-control, cohort, cross-sectional, survey, and surveillance reports) and quasi-randomized and randomized controlled trial studies conducted in LMIC will be included. The Newcastle-Ottawa Scale (NOS) and Joanna Briggs Institute (JBI) critical appraisal checklist will be used to assess the quality of observational and randomized controlled trial studies respectively. The pooled prevalence and odds ratio of determinants of adherence will be generated using a weighted inverse-variance meta-analysis model. Statistical heterogeneity among studies will be assessed by Cochran’s Q χ 2 statistics and Higgins (I 2 statistics) method. The result will be presented using forest plots and Harvest plots when necessary. Furthermore, we will perform Jackknife sensitivity and subgroup analysis. Data will be analyzed using comprehensive meta-analysis software (version 2). Discussion Contemporary evidence about the prevalence and determinants of adherence in LMIC will be synthesized to generate up-to-date knowledge. To our knowledge, this is the first systematic review. It would have substantial implications for researchers, clinicians, and policymakers for optimizing maternal and child health outcomes in LMIC. Systematic review registration The protocol has been registered on International Prospective Register of Systematic Review (PROSPERO), University of York Center for Reviews and Dissemination (https://www.crd.york.ac.uk/), registration number CRD42017080245.http://link.springer.com/article/10.1186/s13643-018-0774-xFolic acidFolateIronMedication adherencePatient compliancePrenatal Nutritional Physiological Phenomena |
| spellingShingle | Mohammed Akibu Tesfalidet Tekelab Abdella Amano Merga Besho Stephanie Grutzmacher Mesfin Tadese Tesfa Dejenie Habtewold Adherence to prenatal iron-folic acid supplementation in low- and middle-income countries (LMIC): a protocol for systematic review and meta-analysis Systematic Reviews Folic acid Folate Iron Medication adherence Patient compliance Prenatal Nutritional Physiological Phenomena |
| title | Adherence to prenatal iron-folic acid supplementation in low- and middle-income countries (LMIC): a protocol for systematic review and meta-analysis |
| title_full | Adherence to prenatal iron-folic acid supplementation in low- and middle-income countries (LMIC): a protocol for systematic review and meta-analysis |
| title_fullStr | Adherence to prenatal iron-folic acid supplementation in low- and middle-income countries (LMIC): a protocol for systematic review and meta-analysis |
| title_full_unstemmed | Adherence to prenatal iron-folic acid supplementation in low- and middle-income countries (LMIC): a protocol for systematic review and meta-analysis |
| title_short | Adherence to prenatal iron-folic acid supplementation in low- and middle-income countries (LMIC): a protocol for systematic review and meta-analysis |
| title_sort | adherence to prenatal iron folic acid supplementation in low and middle income countries lmic a protocol for systematic review and meta analysis |
| topic | Folic acid Folate Iron Medication adherence Patient compliance Prenatal Nutritional Physiological Phenomena |
| url | http://link.springer.com/article/10.1186/s13643-018-0774-x |
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