The impact of carotid plaque presence and morphology on mortality outcome in cardiological patients
<p>Abstract</p> <p>Background</p> <p>Carotid plaque severity and morphology can affect cardiovascular prognosis.</p> <p>We evaluate both the importance of echographically assessed carotid artery plaque geometry and morphology as predictors of death in hospit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2006-03-01
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| Series: | Cardiovascular Ultrasound |
| Online Access: | http://www.cardiovascularultrasound.com/content/4/1/16 |
| _version_ | 1811285538975514624 |
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| author | Pasanisi Emilio Venneri Lucia Peçanha Patricia B Petersen Christina Pratali Lorenza Picano Eugenio |
| author_facet | Pasanisi Emilio Venneri Lucia Peçanha Patricia B Petersen Christina Pratali Lorenza Picano Eugenio |
| author_sort | Pasanisi Emilio |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Carotid plaque severity and morphology can affect cardiovascular prognosis.</p> <p>We evaluate both the importance of echographically assessed carotid artery plaque geometry and morphology as predictors of death in hospitalised cardiological patients.</p> <p>Methods</p> <p>541 hospitalised patients admitted in a cardiological division (age = 66 ± 11 years, 411 men), have been studied through ultrasound Duplex carotid scan and successively followed-up for a median of 34 months. Echo evaluation assessed plaque severity and morphology (presence of heterogeneity and profile).</p> <p>Results</p> <p>361 patients showed carotid stenosis (67% with <50% stenosis, 18% with 50–69% stenosis, 9% with >70% stenosis, 4% with near occlusion and 2% with total occlusion). During the follow-up period, there were 83 all-cause deaths (15% of the total population). Using Cox's proportional hazard model, age (RR 1.06, 95% CI 1.03–1.09, p = 0.000), ejection fraction > 50% (RR = 0.62, 95% CI 0.4–0.96, p = 0.03), treatment with statins (RR = 0.52, 95% CI 0.29–0.95, p = 0.34) and the presence of a heterogeneous plaque (RR 1.6; 95% CI, 1.2 to 2.14, p = 0.002) were independent predictors of death. Kaplan – Meier survival estimates have shown the best outcome in patients without plaque, intermediate in patients with homogeneous plaques and the worst outcome in patients with heterogeneous plaques (90% vs 79% vs 73%, p = 0.0001).</p> <p>Conclusion</p> <p>In hospitalised cardiological patients, carotid plaque presence and morphology assessed by ultrasound are independent predictors of death.</p> |
| first_indexed | 2024-04-13T02:46:32Z |
| format | Article |
| id | doaj.art-210e7c499d47423fbafd4c171d83389e |
| institution | Directory Open Access Journal |
| issn | 1476-7120 |
| language | English |
| last_indexed | 2024-04-13T02:46:32Z |
| publishDate | 2006-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Ultrasound |
| spelling | doaj.art-210e7c499d47423fbafd4c171d83389e2022-12-22T03:06:01ZengBMCCardiovascular Ultrasound1476-71202006-03-01411610.1186/1476-7120-4-16The impact of carotid plaque presence and morphology on mortality outcome in cardiological patientsPasanisi EmilioVenneri LuciaPeçanha Patricia BPetersen ChristinaPratali LorenzaPicano Eugenio<p>Abstract</p> <p>Background</p> <p>Carotid plaque severity and morphology can affect cardiovascular prognosis.</p> <p>We evaluate both the importance of echographically assessed carotid artery plaque geometry and morphology as predictors of death in hospitalised cardiological patients.</p> <p>Methods</p> <p>541 hospitalised patients admitted in a cardiological division (age = 66 ± 11 years, 411 men), have been studied through ultrasound Duplex carotid scan and successively followed-up for a median of 34 months. Echo evaluation assessed plaque severity and morphology (presence of heterogeneity and profile).</p> <p>Results</p> <p>361 patients showed carotid stenosis (67% with <50% stenosis, 18% with 50–69% stenosis, 9% with >70% stenosis, 4% with near occlusion and 2% with total occlusion). During the follow-up period, there were 83 all-cause deaths (15% of the total population). Using Cox's proportional hazard model, age (RR 1.06, 95% CI 1.03–1.09, p = 0.000), ejection fraction > 50% (RR = 0.62, 95% CI 0.4–0.96, p = 0.03), treatment with statins (RR = 0.52, 95% CI 0.29–0.95, p = 0.34) and the presence of a heterogeneous plaque (RR 1.6; 95% CI, 1.2 to 2.14, p = 0.002) were independent predictors of death. Kaplan – Meier survival estimates have shown the best outcome in patients without plaque, intermediate in patients with homogeneous plaques and the worst outcome in patients with heterogeneous plaques (90% vs 79% vs 73%, p = 0.0001).</p> <p>Conclusion</p> <p>In hospitalised cardiological patients, carotid plaque presence and morphology assessed by ultrasound are independent predictors of death.</p>http://www.cardiovascularultrasound.com/content/4/1/16 |
| spellingShingle | Pasanisi Emilio Venneri Lucia Peçanha Patricia B Petersen Christina Pratali Lorenza Picano Eugenio The impact of carotid plaque presence and morphology on mortality outcome in cardiological patients Cardiovascular Ultrasound |
| title | The impact of carotid plaque presence and morphology on mortality outcome in cardiological patients |
| title_full | The impact of carotid plaque presence and morphology on mortality outcome in cardiological patients |
| title_fullStr | The impact of carotid plaque presence and morphology on mortality outcome in cardiological patients |
| title_full_unstemmed | The impact of carotid plaque presence and morphology on mortality outcome in cardiological patients |
| title_short | The impact of carotid plaque presence and morphology on mortality outcome in cardiological patients |
| title_sort | impact of carotid plaque presence and morphology on mortality outcome in cardiological patients |
| url | http://www.cardiovascularultrasound.com/content/4/1/16 |
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