Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through Kv7.4 channel upsurge in auditory neurons and hair cells

Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through Kv7.4 channel upsurge in auditory neurons and hair cells

Repressor element 1-silencing transcription factor (REST) is a transcriptional repressor that recognizes neuron-restrictive silencer elements in the mammalian genomes in a tissue- and cell-specific manner. The identity of REST target genes and molecular details of how REST regulates them are emergin...

Full description

Bibliographic Details
Main Authors: Haiwei Zhang, Hongchen Li, Mingshun Lu, Shengnan Wang, Xueya Ma, Fei Wang, Jiaxi Liu, Xinyu Li, Haichao Yang, Fan Zhang, Haitao Shen, Noel J Buckley, Nikita Gamper, Ebenezer N Yamoah, Ping Lv
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
mouse
human
hearing loss
repressor element
Online Access:https://elifesciences.org/articles/76754

Similar Items

Similar Items