A malignant omental extra-gastrointestinal stromal tumor on a young man: a case report and review of the literature
<p>Abstract</p> <p>Background</p> <p>Gastrointestinal stromal tumors (GIST) are uncommon intra-abdominal tumors. These tumors tend to present with higher frequency in the stomach and small bowel. In fewer than 5% of cases, they originate primarily from the mesentery, om...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-05-01
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| Series: | World Journal of Surgical Oncology |
| Online Access: | http://www.wjso.com/content/6/1/50 |
| _version_ | 1811316580431167488 |
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| author | Almaroof Babatunde Gociman Barbu Tsang Albert W Mancho Salim Castillo-Sang Mario Ahmed Mohammed Y |
| author_facet | Almaroof Babatunde Gociman Barbu Tsang Albert W Mancho Salim Castillo-Sang Mario Ahmed Mohammed Y |
| author_sort | Almaroof Babatunde |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Gastrointestinal stromal tumors (GIST) are uncommon intra-abdominal tumors. These tumors tend to present with higher frequency in the stomach and small bowel. In fewer than 5% of cases, they originate primarily from the mesentery, omentum, or peritoneum. Furthermore, these extra-gastrointestinal tumors (EGIST) tend to be more common in patients greater than 50 years of age. Rarely do EGIST tumors present in those younger than 40 years of age.</p> <p>Case presentation</p> <p>We report a case of a large EGIST in a 27-year-old male. An abdominal pelvic computerized tomography imaging demonstrated an intra-abdominal mass of 22 cm, without invasion of adjacent viscera or liver lesions. This mass was resected <it>en bloc </it>with its fused omentum and an adherent portion of sigmoid colon. Pathology results demonstrated a malignant gastrointestinal stromal tumor with positive CD117 (c-kit) staining, and negative margins of resection, and no continuity of tumor with the sigmoid colon. Due to the malignant and aggressive nature of this patient's tumor, he was started on STI-571 as adjuvant chemotherapy.</p> <p>Conclusion</p> <p>Stromal tumors of an extra-gastrointestinal origin are rare. Of the reported omental and mesenteric EGISTs in four published series, a total of 99 tumors were studied. Of the 99 patients in these series only 8 were under 40 years of age, none were younger than 30 years old; and only 5 were younger than 35 years old. Our patient's age is at the lower end of the age spectrum for the reported EGISTs. Young patients who present with an extra-gastrointestinal stromal tumor (EGIST), who have complete resection with negative margins, have a good prognosis. There is little data to support the role of STI-571 in adjuvant or neoadjuvant therapy after curative resection. Given the lack of data, the use of STI-571 must be individualized.</p> |
| first_indexed | 2024-04-13T11:51:17Z |
| format | Article |
| id | doaj.art-210fc3b807344b4a99bc8c4c2faf10da |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-13T11:51:17Z |
| publishDate | 2008-05-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-210fc3b807344b4a99bc8c4c2faf10da2022-12-22T02:48:01ZengBMCWorld Journal of Surgical Oncology1477-78192008-05-01615010.1186/1477-7819-6-50A malignant omental extra-gastrointestinal stromal tumor on a young man: a case report and review of the literatureAlmaroof BabatundeGociman BarbuTsang Albert WMancho SalimCastillo-Sang MarioAhmed Mohammed Y<p>Abstract</p> <p>Background</p> <p>Gastrointestinal stromal tumors (GIST) are uncommon intra-abdominal tumors. These tumors tend to present with higher frequency in the stomach and small bowel. In fewer than 5% of cases, they originate primarily from the mesentery, omentum, or peritoneum. Furthermore, these extra-gastrointestinal tumors (EGIST) tend to be more common in patients greater than 50 years of age. Rarely do EGIST tumors present in those younger than 40 years of age.</p> <p>Case presentation</p> <p>We report a case of a large EGIST in a 27-year-old male. An abdominal pelvic computerized tomography imaging demonstrated an intra-abdominal mass of 22 cm, without invasion of adjacent viscera or liver lesions. This mass was resected <it>en bloc </it>with its fused omentum and an adherent portion of sigmoid colon. Pathology results demonstrated a malignant gastrointestinal stromal tumor with positive CD117 (c-kit) staining, and negative margins of resection, and no continuity of tumor with the sigmoid colon. Due to the malignant and aggressive nature of this patient's tumor, he was started on STI-571 as adjuvant chemotherapy.</p> <p>Conclusion</p> <p>Stromal tumors of an extra-gastrointestinal origin are rare. Of the reported omental and mesenteric EGISTs in four published series, a total of 99 tumors were studied. Of the 99 patients in these series only 8 were under 40 years of age, none were younger than 30 years old; and only 5 were younger than 35 years old. Our patient's age is at the lower end of the age spectrum for the reported EGISTs. Young patients who present with an extra-gastrointestinal stromal tumor (EGIST), who have complete resection with negative margins, have a good prognosis. There is little data to support the role of STI-571 in adjuvant or neoadjuvant therapy after curative resection. Given the lack of data, the use of STI-571 must be individualized.</p>http://www.wjso.com/content/6/1/50 |
| spellingShingle | Almaroof Babatunde Gociman Barbu Tsang Albert W Mancho Salim Castillo-Sang Mario Ahmed Mohammed Y A malignant omental extra-gastrointestinal stromal tumor on a young man: a case report and review of the literature World Journal of Surgical Oncology |
| title | A malignant omental extra-gastrointestinal stromal tumor on a young man: a case report and review of the literature |
| title_full | A malignant omental extra-gastrointestinal stromal tumor on a young man: a case report and review of the literature |
| title_fullStr | A malignant omental extra-gastrointestinal stromal tumor on a young man: a case report and review of the literature |
| title_full_unstemmed | A malignant omental extra-gastrointestinal stromal tumor on a young man: a case report and review of the literature |
| title_short | A malignant omental extra-gastrointestinal stromal tumor on a young man: a case report and review of the literature |
| title_sort | malignant omental extra gastrointestinal stromal tumor on a young man a case report and review of the literature |
| url | http://www.wjso.com/content/6/1/50 |
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