Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research
Abstract Purpose To review the clinical and research value of optical coherence tomography angiography (OCTA) in the field of neurology. Methods Current literature involving OCTA were reviewed through PubMed using the search terms “optical coherence tomography angiography”, with “multiple sclerosis”...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | Eye and Vision |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40662-018-0104-3 |
| _version_ | 1828155970113503232 |
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| author | Liang Wang Olwen Murphy Natalia Gonzalez Caldito Peter A. Calabresi Shiv Saidha |
| author_facet | Liang Wang Olwen Murphy Natalia Gonzalez Caldito Peter A. Calabresi Shiv Saidha |
| author_sort | Liang Wang |
| collection | DOAJ |
| description | Abstract Purpose To review the clinical and research value of optical coherence tomography angiography (OCTA) in the field of neurology. Methods Current literature involving OCTA were reviewed through PubMed using the search terms “optical coherence tomography angiography”, with “multiple sclerosis”, “Alzheimer’s disease”, “optic neuropathy”, or other closely-related terms. Results OCTA has been applied in research to advance our understanding of the pathobiology of neurological disorders. OCTA-derived blood flow and vessel density measures are altered in multiple sclerosis (MS), Alzheimer’s disease (AD), and various optic neuropathies (ON) in varying regions of the posterior segment vasculature of the eye. These emerging research findings support the occurrence of retinal vascular alterations across a host of neurological disorders and raise the possibility that vasculopathy can be clinically relevant since it contributes to the pathobiology of several neurological disorders. Conclusion OCTA may be beneficial for neurological research. Additional investigations using OCTA in neurological disorders will help to further validate its clinical and research utilities in terms of characterizing the role of vasculopathy in neurological disorders. |
| first_indexed | 2024-04-11T23:02:27Z |
| format | Article |
| id | doaj.art-2110238f60bb41b9805c3ea9e10a82e7 |
| institution | Directory Open Access Journal |
| issn | 2326-0254 |
| language | English |
| last_indexed | 2024-04-11T23:02:27Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Eye and Vision |
| spelling | doaj.art-2110238f60bb41b9805c3ea9e10a82e72022-12-22T03:58:05ZengBMCEye and Vision2326-02542018-05-015111110.1186/s40662-018-0104-3Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological researchLiang Wang0Olwen Murphy1Natalia Gonzalez Caldito2Peter A. Calabresi3Shiv Saidha4Department of Biology, Johns Hopkins University, Krieger School of Arts and SciencesDivision of Neuroimmunology and Neurological Infections, Johns Hopkins HospitalDivision of Neuroimmunology and Neurological Infections, Johns Hopkins HospitalDivision of Neuroimmunology and Neurological Infections, Johns Hopkins HospitalDivision of Neuroimmunology and Neurological Infections, Johns Hopkins HospitalAbstract Purpose To review the clinical and research value of optical coherence tomography angiography (OCTA) in the field of neurology. Methods Current literature involving OCTA were reviewed through PubMed using the search terms “optical coherence tomography angiography”, with “multiple sclerosis”, “Alzheimer’s disease”, “optic neuropathy”, or other closely-related terms. Results OCTA has been applied in research to advance our understanding of the pathobiology of neurological disorders. OCTA-derived blood flow and vessel density measures are altered in multiple sclerosis (MS), Alzheimer’s disease (AD), and various optic neuropathies (ON) in varying regions of the posterior segment vasculature of the eye. These emerging research findings support the occurrence of retinal vascular alterations across a host of neurological disorders and raise the possibility that vasculopathy can be clinically relevant since it contributes to the pathobiology of several neurological disorders. Conclusion OCTA may be beneficial for neurological research. Additional investigations using OCTA in neurological disorders will help to further validate its clinical and research utilities in terms of characterizing the role of vasculopathy in neurological disorders.http://link.springer.com/article/10.1186/s40662-018-0104-3Optical coherence tomography angiographyNeurologyMultiple sclerosisAlzheimer’s diseaseOptic neuropathy |
| spellingShingle | Liang Wang Olwen Murphy Natalia Gonzalez Caldito Peter A. Calabresi Shiv Saidha Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research Eye and Vision Optical coherence tomography angiography Neurology Multiple sclerosis Alzheimer’s disease Optic neuropathy |
| title | Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research |
| title_full | Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research |
| title_fullStr | Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research |
| title_full_unstemmed | Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research |
| title_short | Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research |
| title_sort | emerging applications of optical coherence tomography angiography octa in neurological research |
| topic | Optical coherence tomography angiography Neurology Multiple sclerosis Alzheimer’s disease Optic neuropathy |
| url | http://link.springer.com/article/10.1186/s40662-018-0104-3 |
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