Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case report
Paracetamol is the most widely drug involved in accidental paediatric exposures and deliberate self-poisoning cases because of its availability. N-acetyl cystein is the main treatment for this poisoning. We report a case of a 24-year-old Arab female who has deliberately ingested 100 tablets of 500 m...
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| Format: | Article |
| Language: | English |
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The Pan African Medical Journal
2018-01-01
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| Series: | The Pan African Medical Journal |
| Subjects: | |
| Online Access: |
https://www.panafrican-med-journal.com/content/article/29/83/pdf/83.pdf
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| _version_ | 1818916477250568192 |
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| author | Said Benlamkaddem Imane Iken Nawfal Houari Abderrahim Elbouazzaoui Brahim Boukatta Hicham Sbai Sanae Achour Nabil Kanjaa |
| author_facet | Said Benlamkaddem Imane Iken Nawfal Houari Abderrahim Elbouazzaoui Brahim Boukatta Hicham Sbai Sanae Achour Nabil Kanjaa |
| author_sort | Said Benlamkaddem |
| collection | DOAJ |
| description | Paracetamol is the most widely drug involved in accidental paediatric exposures and deliberate self-poisoning cases because of its availability. N-acetyl cystein is the main treatment for this poisoning. We report a case of a 24-year-old Arab female who has deliberately ingested 100 tablets of 500 mg paracetamol each (50g). Her first examination was normal. She has received oral N-acetyl cystein (NAC) 6 hours after the ingestion. Serum paracetamol level done 18 hours post ingestion was 900 mg/l. On review the next days, she did not develop any symptoms of liver failure. However, due to the massive paracetamol ingestion associated with high serum paracetamol levels, oral NAC was continued for 3 days. The patient was discharged well on the fifth day of hospitalization. Our patient has ingested one of the highest paracetamol overdose (50g) with the highest paracetamol blood levels ever reported in medical literature. She was treated, six hours after ingestion, with oral NAC for 3 days without any side effects. |
| first_indexed | 2024-12-20T00:18:48Z |
| format | Article |
| id | doaj.art-2110a3dfc4784eb19e95695066ae9419 |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-20T00:18:48Z |
| publishDate | 2018-01-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-2110a3dfc4784eb19e95695066ae94192022-12-21T20:00:15ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882018-01-01298310.11604/pamj.2018.29.83.1059510595Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case reportSaid Benlamkaddem0Imane Iken1Nawfal Houari2Abderrahim Elbouazzaoui3Brahim Boukatta4Hicham Sbai5Sanae Achour6Nabil Kanjaa7 Intensive Care Unit, Hassan II University Hospital, Fez, Morocco Laboratory of toxicology, Hassan II University Hospital, Fez, Morocco Intensive Care Unit, Hassan II University Hospital, Fez, Morocco Intensive Care Unit, Hassan II University Hospital, Fez, Morocco Intensive Care Unit, Hassan II University Hospital, Fez, Morocco Intensive Care Unit, Hassan II University Hospital, Fez, Morocco Laboratory of toxicology, Hassan II University Hospital, Fez, Morocco Intensive Care Unit, Hassan II University Hospital, Fez, Morocco Paracetamol is the most widely drug involved in accidental paediatric exposures and deliberate self-poisoning cases because of its availability. N-acetyl cystein is the main treatment for this poisoning. We report a case of a 24-year-old Arab female who has deliberately ingested 100 tablets of 500 mg paracetamol each (50g). Her first examination was normal. She has received oral N-acetyl cystein (NAC) 6 hours after the ingestion. Serum paracetamol level done 18 hours post ingestion was 900 mg/l. On review the next days, she did not develop any symptoms of liver failure. However, due to the massive paracetamol ingestion associated with high serum paracetamol levels, oral NAC was continued for 3 days. The patient was discharged well on the fifth day of hospitalization. Our patient has ingested one of the highest paracetamol overdose (50g) with the highest paracetamol blood levels ever reported in medical literature. She was treated, six hours after ingestion, with oral NAC for 3 days without any side effects. https://www.panafrican-med-journal.com/content/article/29/83/pdf/83.pdf paracetamol self-poisoningn-acetyl cysteincase reportliver failureparacetamol serum concentrationrumack-mathew nomogram |
| spellingShingle | Said Benlamkaddem Imane Iken Nawfal Houari Abderrahim Elbouazzaoui Brahim Boukatta Hicham Sbai Sanae Achour Nabil Kanjaa Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case report The Pan African Medical Journal paracetamol self-poisoning n-acetyl cystein case report liver failure paracetamol serum concentration rumack-mathew nomogram |
| title | Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case report |
| title_full | Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case report |
| title_fullStr | Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case report |
| title_full_unstemmed | Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case report |
| title_short | Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case report |
| title_sort | paracetamol self poisoning when oral n acetylcysteine saves life a case report |
| topic | paracetamol self-poisoning n-acetyl cystein case report liver failure paracetamol serum concentration rumack-mathew nomogram |
| url |
https://www.panafrican-med-journal.com/content/article/29/83/pdf/83.pdf
|
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