S1PR4 deficiency results in reduced germinal center formation but only marginally affects antibody production

S1PR4 deficiency results in reduced germinal center formation but only marginally affects antibody production

IntroductionSplenic B cells exhibit a high expression of the G protein-coupled sphingosine-1-phosphate (S1P) receptor type 4 (S1PR4). Little is known about the functional relevance of S1PR4 expression on those cells.MethodsIn this study, S1PR4-deficient mice were used to study the role of S1PR4-medi...

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Bibliographic Details
Main Authors: Janik Riese, Celine Hähnel, Jonas Menz, Maurice Hannemann, Aydar Khabipov, Felix Lührs, Tobias Schulze
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
B cells
spleen
germinal center reaction
antibody production
abdominal sepsis
Sphingosine-1-phosphate
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1053490/full

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