The role and mechanism of TXNDC5 in disease progression
Thioredoxin domain containing protein-5 (TXNDC5), also known as endothelial protein-disulfide isomerase (Endo-PDI), is confined to the endoplasmic reticulum through the structural endoplasmic reticulum retention signal (KDEL), is a member of the PDI protein family and is highly expressed in the hypo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1354952/full |
| _version_ | 1797229429204713472 |
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| author | Mingxia Jiao Mingxia Jiao Yeyong Zhang Xie Song Xie Song Bing Xu Bing Xu |
| author_facet | Mingxia Jiao Mingxia Jiao Yeyong Zhang Xie Song Xie Song Bing Xu Bing Xu |
| author_sort | Mingxia Jiao |
| collection | DOAJ |
| description | Thioredoxin domain containing protein-5 (TXNDC5), also known as endothelial protein-disulfide isomerase (Endo-PDI), is confined to the endoplasmic reticulum through the structural endoplasmic reticulum retention signal (KDEL), is a member of the PDI protein family and is highly expressed in the hypoxic state. TXNDC5 can regulate the rate of disulfide bond formation, isomerization and degradation of target proteins through its function as a protein disulfide isomerase (PDI), thereby altering protein conformation, activity and improving protein stability. Several studies have shown that there is a significant correlation between TXNDC5 gene polymorphisms and genetic susceptibility to inflammatory diseases such as rheumatoid, fibrosis and tumors. In this paper, we detail the expression characteristics of TXNDC5 in a variety of diseases, summarize the mechanisms by which TXNDC5 promotes malignant disease progression, and summarize potential therapeutic strategies to target TXNDC5 for disease treatment. |
| first_indexed | 2024-04-24T15:12:27Z |
| format | Article |
| id | doaj.art-21112cb8596244c484703ccefb187ac2 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-24T15:12:27Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-21112cb8596244c484703ccefb187ac22024-04-02T10:21:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-04-011510.3389/fimmu.2024.13549521354952The role and mechanism of TXNDC5 in disease progressionMingxia Jiao0Mingxia Jiao1Yeyong Zhang2Xie Song3Xie Song4Bing Xu5Bing Xu6Department of Urology, The First Affiliated Hospital of Shandong First Medical University & Shandong Province Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Organ Transplantation and Nephrosis, Shandong Institute of Nephrology, Jinan, Shandong, ChinaShandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan, Shandong, ChinaShandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaDepartment of Hepatobiliary Surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Urology, The First Affiliated Hospital of Shandong First Medical University & Shandong Province Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Organ Transplantation and Nephrosis, Shandong Institute of Nephrology, Jinan, Shandong, ChinaShandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaThioredoxin domain containing protein-5 (TXNDC5), also known as endothelial protein-disulfide isomerase (Endo-PDI), is confined to the endoplasmic reticulum through the structural endoplasmic reticulum retention signal (KDEL), is a member of the PDI protein family and is highly expressed in the hypoxic state. TXNDC5 can regulate the rate of disulfide bond formation, isomerization and degradation of target proteins through its function as a protein disulfide isomerase (PDI), thereby altering protein conformation, activity and improving protein stability. Several studies have shown that there is a significant correlation between TXNDC5 gene polymorphisms and genetic susceptibility to inflammatory diseases such as rheumatoid, fibrosis and tumors. In this paper, we detail the expression characteristics of TXNDC5 in a variety of diseases, summarize the mechanisms by which TXNDC5 promotes malignant disease progression, and summarize potential therapeutic strategies to target TXNDC5 for disease treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1354952/fullTXNDC5inflammatoryrheumatoid arthritisorgan fibrosistumor |
| spellingShingle | Mingxia Jiao Mingxia Jiao Yeyong Zhang Xie Song Xie Song Bing Xu Bing Xu The role and mechanism of TXNDC5 in disease progression Frontiers in Immunology TXNDC5 inflammatory rheumatoid arthritis organ fibrosis tumor |
| title | The role and mechanism of TXNDC5 in disease progression |
| title_full | The role and mechanism of TXNDC5 in disease progression |
| title_fullStr | The role and mechanism of TXNDC5 in disease progression |
| title_full_unstemmed | The role and mechanism of TXNDC5 in disease progression |
| title_short | The role and mechanism of TXNDC5 in disease progression |
| title_sort | role and mechanism of txndc5 in disease progression |
| topic | TXNDC5 inflammatory rheumatoid arthritis organ fibrosis tumor |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1354952/full |
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