EZH2-inhibitor DZNep enhances apoptosis of renal tubular epithelial cells in presence and absence of cisplatin

EZH2-inhibitor DZNep enhances apoptosis of renal tubular epithelial cells in presence and absence of cisplatin

Abstract Background The enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and induces the trimethylation of histone H3 lysine 27 (H3K27me3) in the promoter of many key genes; EZH2 acts as a transcriptional repressor and is an epigenetic regulator for several cancers. However, the rol...

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Bibliographic Details
Main Authors: Si-qi Chen, Jia-qi Li, Xiao-qiao Wang, Wen-jing Lei, Hao Li, Jiao Wan, Zheng Hu, Yao-wei Zou, Xiao-yu Wu, Hong-xin Niu
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Cell Division
Subjects:
EZH2
Apoptosis
Deptor
Renal tubular cells
Online Access:http://link.springer.com/article/10.1186/s13008-020-00064-3

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