Evaluation of Electrocardiographic Changes in Girls Receiving Gonadotropin-Releasing Hormone Analogs for Precocious Puberty
Aim:Gonadotropin-releasing hormone analogs (GnRHa) are standard medical treatments for precocious puberty. Studies on their side effects in adults have shown that these drugs can cause changes in electrocardiography (ECG), along with some cardiovascular effects; however, the number of studies on chi...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2023-09-01
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| Series: | Journal of Pediatric Research |
| Subjects: | |
| Online Access: |
http://jpedres.org/archives/archive-detail/article-preview/evaluation-of-electrocardiographic-changes-in-girl/62081
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| _version_ | 1797685889662451712 |
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| author | Eren Er Aysun Ata Ali Orgun |
| author_facet | Eren Er Aysun Ata Ali Orgun |
| author_sort | Eren Er |
| collection | DOAJ |
| description | Aim:Gonadotropin-releasing hormone analogs (GnRHa) are standard medical treatments for precocious puberty. Studies on their side effects in adults have shown that these drugs can cause changes in electrocardiography (ECG), along with some cardiovascular effects; however, the number of studies on children is limited. This study investigated the effects of these drugs on ECG parameters in children diagnosed with central precocious puberty (CPP).Materials and Methods:This prospective study included 44 girls who were initiated GnRHa treatment and diagnosed with CPP. ECG was performed before treatment and repeated after 6 months of treatment.Results:The mean age of the children was 9.13±1.55 years. Leuprolide acetate (3.75 mg IM) was administered to all of the patients following the standard protocol. A comparison of the pre-treatment and 6-month ECG parameters revealed a prolonged QT interval after treatment, with a statistically significant difference (p<0.001). There were no significant differences in the pre- and post-treatment values of PR, QRS, QT interval, QTc interval, QT dispersion, or QTc dispersion (p>0.05).Conclusion:Despite a significant increase in QT interval on ECG with GnRHa compared to pre-treatment ECGs, this increase was attributed to a variability in heart rate. Even if regular ECG monitoring is considered after initiation of GnRHa treatment, they are believed to be safe drugs in children. |
| first_indexed | 2024-03-12T00:57:50Z |
| format | Article |
| id | doaj.art-21132c227dec4c33b54ba08b41b77d44 |
| institution | Directory Open Access Journal |
| issn | 2147-9445 2587-2478 |
| language | English |
| last_indexed | 2024-03-12T00:57:50Z |
| publishDate | 2023-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Pediatric Research |
| spelling | doaj.art-21132c227dec4c33b54ba08b41b77d442023-09-14T11:14:18ZengGalenos YayineviJournal of Pediatric Research2147-94452587-24782023-09-0110322222710.4274/jpr.galenos.2023.4875313049054Evaluation of Electrocardiographic Changes in Girls Receiving Gonadotropin-Releasing Hormone Analogs for Precocious PubertyEren Er0Aysun Ata1Ali Orgun2 University of Health Sciences Turkey, İzmir Tepecik Training and Research Hospital, Clinic of Pediatric Endocrinology, İzmir, Turkey Adana City Training and Research Hospital, Clinic of Pediatric Endocrinology, Adana, Turkey Adana City Training and Research Hospital, Clinic of Pediatric Cardiology, Adana, Turkey Aim:Gonadotropin-releasing hormone analogs (GnRHa) are standard medical treatments for precocious puberty. Studies on their side effects in adults have shown that these drugs can cause changes in electrocardiography (ECG), along with some cardiovascular effects; however, the number of studies on children is limited. This study investigated the effects of these drugs on ECG parameters in children diagnosed with central precocious puberty (CPP).Materials and Methods:This prospective study included 44 girls who were initiated GnRHa treatment and diagnosed with CPP. ECG was performed before treatment and repeated after 6 months of treatment.Results:The mean age of the children was 9.13±1.55 years. Leuprolide acetate (3.75 mg IM) was administered to all of the patients following the standard protocol. A comparison of the pre-treatment and 6-month ECG parameters revealed a prolonged QT interval after treatment, with a statistically significant difference (p<0.001). There were no significant differences in the pre- and post-treatment values of PR, QRS, QT interval, QTc interval, QT dispersion, or QTc dispersion (p>0.05).Conclusion:Despite a significant increase in QT interval on ECG with GnRHa compared to pre-treatment ECGs, this increase was attributed to a variability in heart rate. Even if regular ECG monitoring is considered after initiation of GnRHa treatment, they are believed to be safe drugs in children. http://jpedres.org/archives/archive-detail/article-preview/evaluation-of-electrocardiographic-changes-in-girl/62081 ecggnrh agonistprecocious pubertyqtqtcqt dispersionqtc dispersion |
| spellingShingle | Eren Er Aysun Ata Ali Orgun Evaluation of Electrocardiographic Changes in Girls Receiving Gonadotropin-Releasing Hormone Analogs for Precocious Puberty Journal of Pediatric Research ecg gnrh agonist precocious puberty qt qtc qt dispersion qtc dispersion |
| title | Evaluation of Electrocardiographic Changes in Girls Receiving Gonadotropin-Releasing Hormone Analogs for Precocious Puberty |
| title_full | Evaluation of Electrocardiographic Changes in Girls Receiving Gonadotropin-Releasing Hormone Analogs for Precocious Puberty |
| title_fullStr | Evaluation of Electrocardiographic Changes in Girls Receiving Gonadotropin-Releasing Hormone Analogs for Precocious Puberty |
| title_full_unstemmed | Evaluation of Electrocardiographic Changes in Girls Receiving Gonadotropin-Releasing Hormone Analogs for Precocious Puberty |
| title_short | Evaluation of Electrocardiographic Changes in Girls Receiving Gonadotropin-Releasing Hormone Analogs for Precocious Puberty |
| title_sort | evaluation of electrocardiographic changes in girls receiving gonadotropin releasing hormone analogs for precocious puberty |
| topic | ecg gnrh agonist precocious puberty qt qtc qt dispersion qtc dispersion |
| url |
http://jpedres.org/archives/archive-detail/article-preview/evaluation-of-electrocardiographic-changes-in-girl/62081
|
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