In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress
<p>Sodium nitrite (NaNO<sub>2</sub>), a food color fixative and preservative, contributes to carcinogenesis. We investigated the protective role of garlic oil against NaNO<sub>2</sub>-induced abnormalities in metabolic biochemical parameters and oxidative status in male...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2009-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v05p0249.htm |
| _version_ | 1831741423006777344 |
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| author | Hanaa A Hassan, Sherif M El-Agmy, Rajiv L Gaur, Augusta Fernando, Madhwa HG Raj, Allal Ouhtit |
| author_facet | Hanaa A Hassan, Sherif M El-Agmy, Rajiv L Gaur, Augusta Fernando, Madhwa HG Raj, Allal Ouhtit |
| author_sort | Hanaa A Hassan, Sherif M El-Agmy, Rajiv L Gaur, Augusta Fernando, Madhwa HG Raj, Allal Ouhtit |
| collection | DOAJ |
| description | <p>Sodium nitrite (NaNO<sub>2</sub>), a food color fixative and preservative, contributes to carcinogenesis. We investigated the protective role of garlic oil against NaNO<sub>2</sub>-induced abnormalities in metabolic biochemical parameters and oxidative status in male albino rats. NaNO<sub>2</sub> treatment for a period of three months induced a significant increase in serum levels of glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, urea and creatinine as well as hepatic AST and ALT. However, significant decrease was recorded in liver ALP activity, glycogen content, and renal urea and creatinine levels. In parallel, a significant increase in lipid peroxidation, and a decrease in glutathione content and catalase activity were observed in the liver and the kidney. However, garlic oil supplementation showed a remarkable amelioration of these abnormalities. Our data indicate that garlic is a phytoantioxidant with powerful chemopreventive properties against chemically-induced oxidative stress.</p> |
| first_indexed | 2024-12-21T14:16:28Z |
| format | Article |
| id | doaj.art-21146aad78234596aaceea700b1dee1f |
| institution | Directory Open Access Journal |
| issn | 1449-2288 |
| language | English |
| last_indexed | 2024-12-21T14:16:28Z |
| publishDate | 2009-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | International Journal of Biological Sciences |
| spelling | doaj.art-21146aad78234596aaceea700b1dee1f2022-12-21T19:00:54ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882009-01-0153249255In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stressHanaa A Hassan, Sherif M El-Agmy, Rajiv L Gaur, Augusta Fernando, Madhwa HG Raj, Allal Ouhtit<p>Sodium nitrite (NaNO<sub>2</sub>), a food color fixative and preservative, contributes to carcinogenesis. We investigated the protective role of garlic oil against NaNO<sub>2</sub>-induced abnormalities in metabolic biochemical parameters and oxidative status in male albino rats. NaNO<sub>2</sub> treatment for a period of three months induced a significant increase in serum levels of glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, urea and creatinine as well as hepatic AST and ALT. However, significant decrease was recorded in liver ALP activity, glycogen content, and renal urea and creatinine levels. In parallel, a significant increase in lipid peroxidation, and a decrease in glutathione content and catalase activity were observed in the liver and the kidney. However, garlic oil supplementation showed a remarkable amelioration of these abnormalities. Our data indicate that garlic is a phytoantioxidant with powerful chemopreventive properties against chemically-induced oxidative stress.</p>http://www.biolsci.org/v05p0249.htm |
| spellingShingle | Hanaa A Hassan, Sherif M El-Agmy, Rajiv L Gaur, Augusta Fernando, Madhwa HG Raj, Allal Ouhtit In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress International Journal of Biological Sciences |
| title | In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress |
| title_full | In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress |
| title_fullStr | In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress |
| title_full_unstemmed | In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress |
| title_short | In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress |
| title_sort | in vivo evidence of hepato and reno protective effect of garlic oil against sodium nitrite induced oxidative stress |
| url | http://www.biolsci.org/v05p0249.htm |
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