Kinetics and durability of transgene expression after intrastriatal injection of AAV9 vectors

Kinetics and durability of transgene expression after intrastriatal injection of AAV9 vectors

Understanding the kinetics and durability of AAV-mediated transgene expression in the brain is essential for conducting basic neuroscience studies as well as for developing gene therapy approaches for CNS diseases. Here, we characterize and compare the temporal profile of transgene expression after...

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Bibliographic Details
Main Authors: Bradley S. Hollidge, Hayley B. Carroll, Randolph Qian, Madison L. Fuller, April R. Giles, Andrew C. Mercer, Olivier Danos, Ye Liu, Joseph T. Bruder, Jared B. Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Neurology
Subjects:
AAV
promoter
durability
striatum
intraparenchymal
episome
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.1051559/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2022.1051559/full

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