The Ketogenic Diet: Breath Acetone Sensing Technology

The ketogenic diet, while originally thought to treat epilepsy in children, is now used for weight loss due to increasing evidence indicating that fat is burned more rapidly when there is a low carbohydrate intake. This low carbohydrate intake can lead to elevated ketone levels in the blood and brea...

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Main Authors: Omar Alkedeh, Ronny Priefer
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biosensors
Subjects:
Online Access:https://www.mdpi.com/2079-6374/11/1/26
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author Omar Alkedeh
Ronny Priefer
author_facet Omar Alkedeh
Ronny Priefer
author_sort Omar Alkedeh
collection DOAJ
description The ketogenic diet, while originally thought to treat epilepsy in children, is now used for weight loss due to increasing evidence indicating that fat is burned more rapidly when there is a low carbohydrate intake. This low carbohydrate intake can lead to elevated ketone levels in the blood and breath. Breath and blood ketones can be measured to gauge the level of ketosis and allow for adjustment of the diet to meet the user’s needs. Blood ketone levels have been historically used, but now breath acetone sensors are becoming more common due to less invasiveness and convenience. New technologies are being researched in the area of acetone sensors to capitalize on the rising popularity of the diet. Current breath acetone sensors come in the form of handheld breathalyzer devices. Technologies in development mostly consist of semiconductor metal oxides in different physio-chemical formations. These current devices and future technologies are investigated here with regard to utility and efficacy. Technologies currently in development do not have extensive testing of the selectivity of the sensors including the many compounds present in human breath. While some sensors have undergone human testing, the sample sizes are very small, and the testing was not extensive. Data regarding current devices is lacking and more research needs to be done to effectively evaluate current devices if they are to have a place as medical devices. Future technologies are very promising but are still in early development stages.
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spelling doaj.art-2116aec45e1849afad1e868c2c8a8d242023-12-03T13:50:09ZengMDPI AGBiosensors2079-63742021-01-011112610.3390/bios11010026The Ketogenic Diet: Breath Acetone Sensing TechnologyOmar Alkedeh0Ronny Priefer1Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences University, Boston, MA 02115, USADepartment of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences University, Boston, MA 02115, USAThe ketogenic diet, while originally thought to treat epilepsy in children, is now used for weight loss due to increasing evidence indicating that fat is burned more rapidly when there is a low carbohydrate intake. This low carbohydrate intake can lead to elevated ketone levels in the blood and breath. Breath and blood ketones can be measured to gauge the level of ketosis and allow for adjustment of the diet to meet the user’s needs. Blood ketone levels have been historically used, but now breath acetone sensors are becoming more common due to less invasiveness and convenience. New technologies are being researched in the area of acetone sensors to capitalize on the rising popularity of the diet. Current breath acetone sensors come in the form of handheld breathalyzer devices. Technologies in development mostly consist of semiconductor metal oxides in different physio-chemical formations. These current devices and future technologies are investigated here with regard to utility and efficacy. Technologies currently in development do not have extensive testing of the selectivity of the sensors including the many compounds present in human breath. While some sensors have undergone human testing, the sample sizes are very small, and the testing was not extensive. Data regarding current devices is lacking and more research needs to be done to effectively evaluate current devices if they are to have a place as medical devices. Future technologies are very promising but are still in early development stages.https://www.mdpi.com/2079-6374/11/1/26breathalyzeracetoneketogenic dietsemi-conductor metal oxides
spellingShingle Omar Alkedeh
Ronny Priefer
The Ketogenic Diet: Breath Acetone Sensing Technology
Biosensors
breathalyzer
acetone
ketogenic diet
semi-conductor metal oxides
title The Ketogenic Diet: Breath Acetone Sensing Technology
title_full The Ketogenic Diet: Breath Acetone Sensing Technology
title_fullStr The Ketogenic Diet: Breath Acetone Sensing Technology
title_full_unstemmed The Ketogenic Diet: Breath Acetone Sensing Technology
title_short The Ketogenic Diet: Breath Acetone Sensing Technology
title_sort ketogenic diet breath acetone sensing technology
topic breathalyzer
acetone
ketogenic diet
semi-conductor metal oxides
url https://www.mdpi.com/2079-6374/11/1/26
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