Melanoma stimulates the proteolytic activity of HaCaT keratinocytes

Melanoma stimulates the proteolytic activity of HaCaT keratinocytes

Abstract Background Keratinocytes constitute a major part of the melanoma microenvironment, considering their protective role towards melanocytes in physiological conditions. However, their interactions with tumor cells following melanomagenesis are still unclear. Methods We used two in vitro models...

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Bibliographic Details
Main Authors: Justyna Mazurkiewicz, Aleksandra Simiczyjew, Ewelina Dratkiewicz, Magdalena Kot, Katarzyna Pietraszek-Gremplewicz, Dominika Wilk, Marcin Ziętek, Rafał Matkowski, Dorota Nowak
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Cell Communication and Signaling
Subjects:
HaCaT
Melanoma
Tumor microenvironment
Proteolysis
Migration
Invasion
Online Access:https://doi.org/10.1186/s12964-022-00961-w

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