Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis
Th17 cells produce a range of characteristic Th17 type cytokines and express transcription factors governed by epigenetic regulation to engage the Th17 programme. Here the authors implicate the RNA 5- methylcytosine (m5C) methyltransferase Nsun2 in Th17 cells and the promotion of colitis in a murine...
Main Authors: | Wen-Lan Yang, Weinan Qiu, Ting Zhang, Kai Xu, Zi-Juan Gu, Yu Zhou, Heng-Ji Xu, Zhong-Zhou Yang, Bin Shen, Yong-Liang Zhao, Qi Zhou, Ying Yang, Wei Li, Peng-Yuan Yang, Yun-Gui Yang |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-02-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-36595-w |
Similar Items
-
Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases
by: Jiuping Zeng, et al.
Published: (2023-06-01) -
RORγt inhibitors suppress TH17 responses in inflammatory arthritis and inflammatory bowel disease.
by: de Wit, J, et al.
Published: (2015) -
RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation
by: Amir Kumar Singh, et al.
Published: (2023-08-01) -
AIM2 promotes TH17 cells differentiation by regulating RORγt transcription activity
by: Jefferson Antônio Leite, et al.
Published: (2023-11-01) -
Salidroside affects the Th17/Treg cell balance in aplastic anemia via the STAT3/HIF-1α/RORγt pathway
by: Zenghui Liu, et al.
Published: (2023-12-01)