Caspase-3 Inhibition Attenuates the Cytopathic Effects of EV71 Infection

Caspase-3 Inhibition Attenuates the Cytopathic Effects of EV71 Infection

Previous studies demonstrate that human enterovirus 71 (EV71), a primary causative agent for hand, foot, and mouth disease, activates caspase-3 through the non-structural viral 3C protein to induce host cell apoptosis; however, until now it was unclear how 3C activates caspase-3 and how caspase-3 ac...

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Bibliographic Details
Main Authors: Fengmei Song, Xiaoyan Yu, Ting Zhong, Zengyan Wang, Xiangling Meng, Zhaolong Li, Shuxia Zhang, Wenbo Huo, Xin Liu, Yahong Zhang, Wenyan Zhang, Jinghua Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Microbiology
Subjects:
EV71
caspase-3
viral production
non-structural protein 3C
host–pathogen interaction
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00817/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00817/full

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