Forging the microbiome to help us live long and prosper.
Aging is often accompanied by an increased risk of an array of diseases spanning the cardiovascular, nervous, and immune systems, among others. Despite remarkable progress in understanding the cellular and molecular mechanisms involved in aging, the role of the microbiome remains understudied. In th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-04-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3002087 |
| _version_ | 1797810974727602176 |
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| author | Rachel R Rock Peter J Turnbaugh |
| author_facet | Rachel R Rock Peter J Turnbaugh |
| author_sort | Rachel R Rock |
| collection | DOAJ |
| description | Aging is often accompanied by an increased risk of an array of diseases spanning the cardiovascular, nervous, and immune systems, among others. Despite remarkable progress in understanding the cellular and molecular mechanisms involved in aging, the role of the microbiome remains understudied. In this Essay, we highlight recent progress towards understanding if and how the microbiome contributes to aging and age-associated diseases. Furthermore, we discuss the need to consider sexually dimorphic phenotypes in the context of aging and the microbiome. We also highlight the broad implications for this emerging area of interdisciplinary research to address long-standing questions about host-microbiome interactions across the life span. |
| first_indexed | 2024-03-13T07:15:44Z |
| format | Article |
| id | doaj.art-21196762d26e48b8b238a1e2ec8be45d |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-03-13T07:15:44Z |
| publishDate | 2023-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-21196762d26e48b8b238a1e2ec8be45d2023-06-05T05:31:13ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852023-04-01214e300208710.1371/journal.pbio.3002087Forging the microbiome to help us live long and prosper.Rachel R RockPeter J TurnbaughAging is often accompanied by an increased risk of an array of diseases spanning the cardiovascular, nervous, and immune systems, among others. Despite remarkable progress in understanding the cellular and molecular mechanisms involved in aging, the role of the microbiome remains understudied. In this Essay, we highlight recent progress towards understanding if and how the microbiome contributes to aging and age-associated diseases. Furthermore, we discuss the need to consider sexually dimorphic phenotypes in the context of aging and the microbiome. We also highlight the broad implications for this emerging area of interdisciplinary research to address long-standing questions about host-microbiome interactions across the life span.https://doi.org/10.1371/journal.pbio.3002087 |
| spellingShingle | Rachel R Rock Peter J Turnbaugh Forging the microbiome to help us live long and prosper. PLoS Biology |
| title | Forging the microbiome to help us live long and prosper. |
| title_full | Forging the microbiome to help us live long and prosper. |
| title_fullStr | Forging the microbiome to help us live long and prosper. |
| title_full_unstemmed | Forging the microbiome to help us live long and prosper. |
| title_short | Forging the microbiome to help us live long and prosper. |
| title_sort | forging the microbiome to help us live long and prosper |
| url | https://doi.org/10.1371/journal.pbio.3002087 |
| work_keys_str_mv | AT rachelrrock forgingthemicrobiometohelpuslivelongandprosper AT peterjturnbaugh forgingthemicrobiometohelpuslivelongandprosper |