Evaluation of urinary neutrophil gelatinase‐associated lipocalin to detect renal tubular damage in dogs with stable myxomatous mitral valve disease
Abstract Background Dogs with myxomatous mitral valve disease (MMVD) can experience progressive renal tubular damage and dysfunction. The prevalence of renal tubular damage is not known in dogs with stable MMVD. Objective To evaluate renal tubular damage in dogs with stable MMVD by evaluation of uri...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16503 |
| _version_ | 1797976836556193792 |
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| author | Roberta Troia Maria Chiara Sabetti Serena Crosara Cecilia Quintavalla Giovanni Romito Chiara Mazzoldi Francesca Fidanzio Maura Cescatti Walter Bertazzolo Massimo Giunti Francesco Dondi |
| author_facet | Roberta Troia Maria Chiara Sabetti Serena Crosara Cecilia Quintavalla Giovanni Romito Chiara Mazzoldi Francesca Fidanzio Maura Cescatti Walter Bertazzolo Massimo Giunti Francesco Dondi |
| author_sort | Roberta Troia |
| collection | DOAJ |
| description | Abstract Background Dogs with myxomatous mitral valve disease (MMVD) can experience progressive renal tubular damage and dysfunction. The prevalence of renal tubular damage is not known in dogs with stable MMVD. Objective To evaluate renal tubular damage in dogs with stable MMVD by evaluation of urinary neutrophil gelatinase‐associated lipocalin (NGAL). Animals Ninety‐eight MMVD dogs grouped according to the American College of Veterinary Internal Medicine (ACVIM) staging (group B1, n = 23; group B2, n = 27; group C + D, n = 48) and 46 healthy dogs. Methods Multicenter prospective observational study. Serum and urine chemistry including NGAL reported as uNGAL concentration (uNGAL) and normalized with urinary creatinine (uNGALC) were compared between MMVD dogs and healthy controls, and among different MMVD ACVIM stages. Results The MMVD dogs had significantly higher uNGAL and uNGALC (1204 pg/mL; range, 30‐39 732 and 1816 pg/mg; range, 22‐127 693, respectively) compared to healthy dogs (584 pg/mL; range, 56‐4072 and 231 pg/mg; range, 15‐2407, respectively; P = .002 and P < .0001, respectively). Both uNGAL and uNGALC increased with the increasing ACVIM stage (P = .001 and P < .001, respectively). Conclusions and Clinical Importance Renal tubular damage is present in dogs with stable MMVD, as measured by increased uNGAL. This tubular damage is subclinical, occurs in all stages of MMVD even in the absence of azotemia, and increases with the severity of MMVD. Reno‐protective approaches to manage MMVD dogs should be explored to slow the progression of renal tubular damage in these patients. |
| first_indexed | 2024-04-11T04:57:19Z |
| format | Article |
| id | doaj.art-2119baf2733841b886afd6be8d1d4f99 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-11T04:57:19Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-2119baf2733841b886afd6be8d1d4f992022-12-26T07:32:23ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762022-11-013662053206210.1111/jvim.16503Evaluation of urinary neutrophil gelatinase‐associated lipocalin to detect renal tubular damage in dogs with stable myxomatous mitral valve diseaseRoberta Troia0Maria Chiara Sabetti1Serena Crosara2Cecilia Quintavalla3Giovanni Romito4Chiara Mazzoldi5Francesca Fidanzio6Maura Cescatti7Walter Bertazzolo8Massimo Giunti9Francesco Dondi10Department of Veterinary Medical Sciences Alma Mater Studiorum—University of Bologna Bologna ItalyDepartment of Veterinary Medical Sciences Alma Mater Studiorum—University of Bologna Bologna ItalyDepartment of Veterinary Sciences University of Parma Parma ItalyDepartment of Veterinary Sciences University of Parma Parma ItalyDepartment of Veterinary Medical Sciences Alma Mater Studiorum—University of Bologna Bologna ItalyDepartment of Veterinary Medical Sciences Alma Mater Studiorum—University of Bologna Bologna ItalyDepartment of Veterinary Sciences University of Parma Parma ItalyFondazione IRET Bologna ItalyMylav‐Laboratorio La Vallonea Milan ItalyDepartment of Veterinary Medical Sciences Alma Mater Studiorum—University of Bologna Bologna ItalyDepartment of Veterinary Medical Sciences Alma Mater Studiorum—University of Bologna Bologna ItalyAbstract Background Dogs with myxomatous mitral valve disease (MMVD) can experience progressive renal tubular damage and dysfunction. The prevalence of renal tubular damage is not known in dogs with stable MMVD. Objective To evaluate renal tubular damage in dogs with stable MMVD by evaluation of urinary neutrophil gelatinase‐associated lipocalin (NGAL). Animals Ninety‐eight MMVD dogs grouped according to the American College of Veterinary Internal Medicine (ACVIM) staging (group B1, n = 23; group B2, n = 27; group C + D, n = 48) and 46 healthy dogs. Methods Multicenter prospective observational study. Serum and urine chemistry including NGAL reported as uNGAL concentration (uNGAL) and normalized with urinary creatinine (uNGALC) were compared between MMVD dogs and healthy controls, and among different MMVD ACVIM stages. Results The MMVD dogs had significantly higher uNGAL and uNGALC (1204 pg/mL; range, 30‐39 732 and 1816 pg/mg; range, 22‐127 693, respectively) compared to healthy dogs (584 pg/mL; range, 56‐4072 and 231 pg/mg; range, 15‐2407, respectively; P = .002 and P < .0001, respectively). Both uNGAL and uNGALC increased with the increasing ACVIM stage (P = .001 and P < .001, respectively). Conclusions and Clinical Importance Renal tubular damage is present in dogs with stable MMVD, as measured by increased uNGAL. This tubular damage is subclinical, occurs in all stages of MMVD even in the absence of azotemia, and increases with the severity of MMVD. Reno‐protective approaches to manage MMVD dogs should be explored to slow the progression of renal tubular damage in these patients.https://doi.org/10.1111/jvim.16503acute kidney injurycardiorenal syndromeheart failurerenal biomarkertubular damage |
| spellingShingle | Roberta Troia Maria Chiara Sabetti Serena Crosara Cecilia Quintavalla Giovanni Romito Chiara Mazzoldi Francesca Fidanzio Maura Cescatti Walter Bertazzolo Massimo Giunti Francesco Dondi Evaluation of urinary neutrophil gelatinase‐associated lipocalin to detect renal tubular damage in dogs with stable myxomatous mitral valve disease Journal of Veterinary Internal Medicine acute kidney injury cardiorenal syndrome heart failure renal biomarker tubular damage |
| title | Evaluation of urinary neutrophil gelatinase‐associated lipocalin to detect renal tubular damage in dogs with stable myxomatous mitral valve disease |
| title_full | Evaluation of urinary neutrophil gelatinase‐associated lipocalin to detect renal tubular damage in dogs with stable myxomatous mitral valve disease |
| title_fullStr | Evaluation of urinary neutrophil gelatinase‐associated lipocalin to detect renal tubular damage in dogs with stable myxomatous mitral valve disease |
| title_full_unstemmed | Evaluation of urinary neutrophil gelatinase‐associated lipocalin to detect renal tubular damage in dogs with stable myxomatous mitral valve disease |
| title_short | Evaluation of urinary neutrophil gelatinase‐associated lipocalin to detect renal tubular damage in dogs with stable myxomatous mitral valve disease |
| title_sort | evaluation of urinary neutrophil gelatinase associated lipocalin to detect renal tubular damage in dogs with stable myxomatous mitral valve disease |
| topic | acute kidney injury cardiorenal syndrome heart failure renal biomarker tubular damage |
| url | https://doi.org/10.1111/jvim.16503 |
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