Bacteremia in Patients with Sepsis in the ICU: Does It Make a Difference?
Sepsis (and septic shock) is on of the most common causes of death worldwide. Bacteremia often, but not necessarily, occurs in septic patients, but the impact of true bacteremia on a patient’s clinical characteristics and outcome remains unclear. The main aim of this study was to compare the charact...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/9/2357 |
| _version_ | 1797578720213467136 |
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| author | Tomáš Nejtek Martin Müller Michal Moravec Miroslav Průcha Roman Zazula |
| author_facet | Tomáš Nejtek Martin Müller Michal Moravec Miroslav Průcha Roman Zazula |
| author_sort | Tomáš Nejtek |
| collection | DOAJ |
| description | Sepsis (and septic shock) is on of the most common causes of death worldwide. Bacteremia often, but not necessarily, occurs in septic patients, but the impact of true bacteremia on a patient’s clinical characteristics and outcome remains unclear. The main aim of this study was to compare the characteristics and outcome of a well-defined cohort of 258 septic patients with and without bacteremia treated in the intensive care unit (ICU) of a tertiary center hospital in Prague, Czech Republic. As expected, more frequently, bacteremia was present in patients without previous antibiotic treatment. A higher proportion of bacteremia was observed in patients with infective endocarditis as well as catheter-related and soft tissue infections in contrast to respiratory sepsis. Multivariant analysis showed increased severity of clinical status and higher Charlson comorbidity index (CCI) as variables with significant influence on mortality. Bacteremia appears to be associated with higher mortality rates and length of ICU stay in comparison with nonbacteremic counterparts, but this difference did not reach statistical significance. The presence of bacteremia, apart from previous antibiotic treatment, may be related to the site of infection. |
| first_indexed | 2024-03-10T22:25:49Z |
| format | Article |
| id | doaj.art-2119eac81cbf420e997ee2e5beacd054 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T22:25:49Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-2119eac81cbf420e997ee2e5beacd0542023-11-19T12:04:14ZengMDPI AGMicroorganisms2076-26072023-09-01119235710.3390/microorganisms11092357Bacteremia in Patients with Sepsis in the ICU: Does It Make a Difference?Tomáš Nejtek0Martin Müller1Michal Moravec2Miroslav Průcha3Roman Zazula4Department of Epidemiology, Faculty of Military Science, University of Defence, 500 01 Hradec Králové, Czech RepublicDepartment of Anesthesiology and Intensive Care, First Faculty of Medicine, Charles University and Thomayer University Hospital, 140 59 Prague, Czech RepublicDepartment of Epidemiology, Faculty of Military Science, University of Defence, 500 01 Hradec Králové, Czech RepublicDepartment of Clinical Biochemistry, Hematology and Immunology, Na Homolce Hospital, 150 00 Prague, Czech RepublicDepartment of Anesthesiology and Intensive Care, First Faculty of Medicine, Charles University and Thomayer University Hospital, 140 59 Prague, Czech RepublicSepsis (and septic shock) is on of the most common causes of death worldwide. Bacteremia often, but not necessarily, occurs in septic patients, but the impact of true bacteremia on a patient’s clinical characteristics and outcome remains unclear. The main aim of this study was to compare the characteristics and outcome of a well-defined cohort of 258 septic patients with and without bacteremia treated in the intensive care unit (ICU) of a tertiary center hospital in Prague, Czech Republic. As expected, more frequently, bacteremia was present in patients without previous antibiotic treatment. A higher proportion of bacteremia was observed in patients with infective endocarditis as well as catheter-related and soft tissue infections in contrast to respiratory sepsis. Multivariant analysis showed increased severity of clinical status and higher Charlson comorbidity index (CCI) as variables with significant influence on mortality. Bacteremia appears to be associated with higher mortality rates and length of ICU stay in comparison with nonbacteremic counterparts, but this difference did not reach statistical significance. The presence of bacteremia, apart from previous antibiotic treatment, may be related to the site of infection.https://www.mdpi.com/2076-2607/11/9/2357sepsisseptic shockSepsis-3bacteremiaoutcomeICU |
| spellingShingle | Tomáš Nejtek Martin Müller Michal Moravec Miroslav Průcha Roman Zazula Bacteremia in Patients with Sepsis in the ICU: Does It Make a Difference? Microorganisms sepsis septic shock Sepsis-3 bacteremia outcome ICU |
| title | Bacteremia in Patients with Sepsis in the ICU: Does It Make a Difference? |
| title_full | Bacteremia in Patients with Sepsis in the ICU: Does It Make a Difference? |
| title_fullStr | Bacteremia in Patients with Sepsis in the ICU: Does It Make a Difference? |
| title_full_unstemmed | Bacteremia in Patients with Sepsis in the ICU: Does It Make a Difference? |
| title_short | Bacteremia in Patients with Sepsis in the ICU: Does It Make a Difference? |
| title_sort | bacteremia in patients with sepsis in the icu does it make a difference |
| topic | sepsis septic shock Sepsis-3 bacteremia outcome ICU |
| url | https://www.mdpi.com/2076-2607/11/9/2357 |
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