Effect of Rheumatoid Factor on Vascular Stiffness in General Population without Joint Symptoms
ObjectivesThe role of rheumatoid factor (RF) in vascular stiffness and cardiovascular risk in subjects without joint symptoms remains unclear. We investigated vascular stiffness in subjects without joint symptoms using pulse wave velocity (PWV), calculated Framingham risk scores (FRS), an estimator...
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| Format: | Article |
| Language: | English |
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Kosin University College of Medicine
2017-01-01
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| Series: | Kosin Medical Journal |
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| Online Access: | http://www.kosinmedj.org/upload/pdf/ksmc032-01-03.pdf |
| _version_ | 1811192575518834688 |
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| author | Ji Hyun Lee Hee Sang Tag Geun Tae Kim Min Jeong Kim Seung Geun Lee Eun Kyung Park Dong Wa Koo |
| author_facet | Ji Hyun Lee Hee Sang Tag Geun Tae Kim Min Jeong Kim Seung Geun Lee Eun Kyung Park Dong Wa Koo |
| author_sort | Ji Hyun Lee |
| collection | DOAJ |
| description | ObjectivesThe role of rheumatoid factor (RF) in vascular stiffness and cardiovascular risk in subjects without joint symptoms remains unclear. We investigated vascular stiffness in subjects without joint symptoms using pulse wave velocity (PWV), calculated Framingham risk scores (FRS), an estimator of cardiovascular risk, and analyzed whether vascular stiffness and FRS were affected by RF. MethodsTwo hundred forty-two subjects were included in this population-based study. RF was quantified with turbid immunometry using a cut-off of RF > 15 IU/ml to denote RF positivity. Information was then obtained on joint symptoms. Brachial-ankle PWV (baPWV) was measured using an automated device. ResultsOf the 242 subjects, 15 were RF-positive. RF-positive subjects without joint symptoms had a higher baPWV and FRS than RF-negative subjects without joint symptoms, but the difference did not reach statistical significance. However, when we stratified the subjects into two groups (group A – high RF: RF ≥ 40 IU/ml; group B – low RF: RF < 40 IU/ml), group A showed significantly higher baPWV (1640.7 ± 179.6 ㎝/s vs. 1405.7 ± 225.7 ㎝/s, P= 0.008) and FRS (25.7 ± 4.87 vs. 11.8 ± 9.6, P< 0.001). Multiple regression analysis was used to examine potential confounders, and RF exhibited significant but modest effects on baPWV (adjusted R-squared = 0.038, P= 0.030). ConclusionsIn a sample of the general population without joint symptoms, higher levels of RF were associated with increased vascular stiffness, suggesting a pathophysiologic link between RF and endothelial dysfunction. |
| first_indexed | 2024-04-11T23:56:00Z |
| format | Article |
| id | doaj.art-211a338f61334a278c1e5956ce14fb03 |
| institution | Directory Open Access Journal |
| issn | 2005-9531 2586-7024 |
| language | English |
| last_indexed | 2024-04-11T23:56:00Z |
| publishDate | 2017-01-01 |
| publisher | Kosin University College of Medicine |
| record_format | Article |
| series | Kosin Medical Journal |
| spelling | doaj.art-211a338f61334a278c1e5956ce14fb032022-12-22T03:56:22ZengKosin University College of MedicineKosin Medical Journal2005-95312586-70242017-01-01321253510.7180/kmj.2017.32.1.25198Effect of Rheumatoid Factor on Vascular Stiffness in General Population without Joint SymptomsJi Hyun Lee0Hee Sang Tag1Geun Tae Kim2Min Jeong Kim3Seung Geun Lee4Eun Kyung Park5Dong Wa Koo6Division of Rheumatology, Department of Internal Medicine, Maryknoll Medical Center, Busan, KoreaDivision of Rheumatology, Department of Internal Medicine, College of Medicine, Kosin University, Busan, KoreaDivision of Rheumatology, Department of Internal Medicine, College of Medicine, Kosin University, Busan, KoreaDepartment of Neurology, College of Medicine, Kosin University, Busan, KoreaDivision of Rheumatology, Department of Internal Medicine, Pusan National University Hospital, Busan, KoreaDivision of Rheumatology, Department of Internal Medicine, Pusan National University Hospital, Busan, KoreaDivision of Rheumatology, Department of Internal Medicine, Pusan National University Hospital, Busan, KoreaObjectivesThe role of rheumatoid factor (RF) in vascular stiffness and cardiovascular risk in subjects without joint symptoms remains unclear. We investigated vascular stiffness in subjects without joint symptoms using pulse wave velocity (PWV), calculated Framingham risk scores (FRS), an estimator of cardiovascular risk, and analyzed whether vascular stiffness and FRS were affected by RF. MethodsTwo hundred forty-two subjects were included in this population-based study. RF was quantified with turbid immunometry using a cut-off of RF > 15 IU/ml to denote RF positivity. Information was then obtained on joint symptoms. Brachial-ankle PWV (baPWV) was measured using an automated device. ResultsOf the 242 subjects, 15 were RF-positive. RF-positive subjects without joint symptoms had a higher baPWV and FRS than RF-negative subjects without joint symptoms, but the difference did not reach statistical significance. However, when we stratified the subjects into two groups (group A – high RF: RF ≥ 40 IU/ml; group B – low RF: RF < 40 IU/ml), group A showed significantly higher baPWV (1640.7 ± 179.6 ㎝/s vs. 1405.7 ± 225.7 ㎝/s, P= 0.008) and FRS (25.7 ± 4.87 vs. 11.8 ± 9.6, P< 0.001). Multiple regression analysis was used to examine potential confounders, and RF exhibited significant but modest effects on baPWV (adjusted R-squared = 0.038, P= 0.030). ConclusionsIn a sample of the general population without joint symptoms, higher levels of RF were associated with increased vascular stiffness, suggesting a pathophysiologic link between RF and endothelial dysfunction.http://www.kosinmedj.org/upload/pdf/ksmc032-01-03.pdfpulse wave analysisrheumatoid factorvascular stiffness |
| spellingShingle | Ji Hyun Lee Hee Sang Tag Geun Tae Kim Min Jeong Kim Seung Geun Lee Eun Kyung Park Dong Wa Koo Effect of Rheumatoid Factor on Vascular Stiffness in General Population without Joint Symptoms Kosin Medical Journal pulse wave analysis rheumatoid factor vascular stiffness |
| title | Effect of Rheumatoid Factor on Vascular Stiffness in General Population without Joint Symptoms |
| title_full | Effect of Rheumatoid Factor on Vascular Stiffness in General Population without Joint Symptoms |
| title_fullStr | Effect of Rheumatoid Factor on Vascular Stiffness in General Population without Joint Symptoms |
| title_full_unstemmed | Effect of Rheumatoid Factor on Vascular Stiffness in General Population without Joint Symptoms |
| title_short | Effect of Rheumatoid Factor on Vascular Stiffness in General Population without Joint Symptoms |
| title_sort | effect of rheumatoid factor on vascular stiffness in general population without joint symptoms |
| topic | pulse wave analysis rheumatoid factor vascular stiffness |
| url | http://www.kosinmedj.org/upload/pdf/ksmc032-01-03.pdf |
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