HISTOLOGI HATI MENCIT (Mus musculus L.) YANG DIBERI EKSTRAK DAUN LAMTORO (Leucaena leucocephala)
Leucaena (Leucaena leucocephala) has been used as traditional medicine, such as<br />drugs to decrease the level of blood glucose, so it can be used as drug to indicate<br />diabetes. The aim of this research is to study the histopathological change of mice’s liver<br />given leuca...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universitas Udayana
2014-09-01
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| Series: | Simbiosis: Journal of Biological Sciences |
| Online Access: | http://ojs.unud.ac.id/index.php/simbiosis/article/view/9781 |
| _version_ | 1828928200191770624 |
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| author | I Wayan Andi Yoga Kurniawan Ngurah Intan Wiratmini Ni Wayan Ni Wayan Sudatri |
| author_facet | I Wayan Andi Yoga Kurniawan Ngurah Intan Wiratmini Ni Wayan Ni Wayan Sudatri |
| author_sort | I Wayan Andi Yoga Kurniawan |
| collection | DOAJ |
| description | Leucaena (Leucaena leucocephala) has been used as traditional medicine, such as<br />drugs to decrease the level of blood glucose, so it can be used as drug to indicate<br />diabetes. The aim of this research is to study the histopathological change of mice’s liver<br />given leucaena leaf extract. This research used 24 male mice that were divided into 4 groups<br />by completely randomized design. Group P0 (control) were given 0,9 % NaCl, and groups<br />P1, P2, and P3 were given 0,5 g / kg bw, 1 g / kg bw, and 1,5 g / kg bw leucaena’s leaf<br />extract by oral administration respectively. The treatment were given daily for 30 days. All of<br />the mice were necropsied at day 31, and the liver were taken to examine their<br />histopathological change. Histopathological change examination were based on the present<br />hydropic degeneration, fatty degeneration, and apoptosis surround central vein. Result of<br />statistically analised by ANOVA and Kruskal-Wallis method indicated no significance<br />difference among the control and treatments. There was no significance toxicity effect of<br />leucaena leaf extract of all treatment dosage on mice liver.<br />Keywords: Leucaena leucocephala, liver histology, Mus musculus L. |
| first_indexed | 2024-12-14T00:00:52Z |
| format | Article |
| id | doaj.art-211a7c373a7347258790c901d7ddebf7 |
| institution | Directory Open Access Journal |
| issn | 2337-7224 |
| language | English |
| last_indexed | 2024-12-14T00:00:52Z |
| publishDate | 2014-09-01 |
| publisher | Universitas Udayana |
| record_format | Article |
| series | Simbiosis: Journal of Biological Sciences |
| spelling | doaj.art-211a7c373a7347258790c901d7ddebf72022-12-21T23:26:20ZengUniversitas UdayanaSimbiosis: Journal of Biological Sciences2337-72242014-09-01228146HISTOLOGI HATI MENCIT (Mus musculus L.) YANG DIBERI EKSTRAK DAUN LAMTORO (Leucaena leucocephala)I Wayan Andi Yoga Kurniawan0Ngurah Intan Wiratmini1Ni Wayan Ni Wayan Sudatri2Jurusan Biologi, F. MIPA, Universitas UdayanaJurusan Biologi, F. MIPA, Universitas UdayanaJurusan Biologi, F. MIPA, Universitas UdayanaLeucaena (Leucaena leucocephala) has been used as traditional medicine, such as<br />drugs to decrease the level of blood glucose, so it can be used as drug to indicate<br />diabetes. The aim of this research is to study the histopathological change of mice’s liver<br />given leucaena leaf extract. This research used 24 male mice that were divided into 4 groups<br />by completely randomized design. Group P0 (control) were given 0,9 % NaCl, and groups<br />P1, P2, and P3 were given 0,5 g / kg bw, 1 g / kg bw, and 1,5 g / kg bw leucaena’s leaf<br />extract by oral administration respectively. The treatment were given daily for 30 days. All of<br />the mice were necropsied at day 31, and the liver were taken to examine their<br />histopathological change. Histopathological change examination were based on the present<br />hydropic degeneration, fatty degeneration, and apoptosis surround central vein. Result of<br />statistically analised by ANOVA and Kruskal-Wallis method indicated no significance<br />difference among the control and treatments. There was no significance toxicity effect of<br />leucaena leaf extract of all treatment dosage on mice liver.<br />Keywords: Leucaena leucocephala, liver histology, Mus musculus L.http://ojs.unud.ac.id/index.php/simbiosis/article/view/9781 |
| spellingShingle | I Wayan Andi Yoga Kurniawan Ngurah Intan Wiratmini Ni Wayan Ni Wayan Sudatri HISTOLOGI HATI MENCIT (Mus musculus L.) YANG DIBERI EKSTRAK DAUN LAMTORO (Leucaena leucocephala) Simbiosis: Journal of Biological Sciences |
| title | HISTOLOGI HATI MENCIT (Mus musculus L.) YANG DIBERI EKSTRAK DAUN LAMTORO (Leucaena leucocephala) |
| title_full | HISTOLOGI HATI MENCIT (Mus musculus L.) YANG DIBERI EKSTRAK DAUN LAMTORO (Leucaena leucocephala) |
| title_fullStr | HISTOLOGI HATI MENCIT (Mus musculus L.) YANG DIBERI EKSTRAK DAUN LAMTORO (Leucaena leucocephala) |
| title_full_unstemmed | HISTOLOGI HATI MENCIT (Mus musculus L.) YANG DIBERI EKSTRAK DAUN LAMTORO (Leucaena leucocephala) |
| title_short | HISTOLOGI HATI MENCIT (Mus musculus L.) YANG DIBERI EKSTRAK DAUN LAMTORO (Leucaena leucocephala) |
| title_sort | histologi hati mencit mus musculus l yang diberi ekstrak daun lamtoro leucaena leucocephala |
| url | http://ojs.unud.ac.id/index.php/simbiosis/article/view/9781 |
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