Plant-Based Vaccines in Combat against Coronavirus Diseases
Coronavirus (CoV) diseases, including Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS) have gained in importance worldwide, especially with the current COVID-19 pandemic caused by SARS-CoV-2. Due to the huge global demand, various types of vaccines have been devel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/2/138 |
| _version_ | 1827652348167585792 |
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| author | Benita Ortega-Berlanga Tomasz Pniewski |
| author_facet | Benita Ortega-Berlanga Tomasz Pniewski |
| author_sort | Benita Ortega-Berlanga |
| collection | DOAJ |
| description | Coronavirus (CoV) diseases, including Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS) have gained in importance worldwide, especially with the current COVID-19 pandemic caused by SARS-CoV-2. Due to the huge global demand, various types of vaccines have been developed, such as more traditional attenuated or inactivated viruses, subunit and VLP-based vaccines, as well as novel DNA and RNA vaccines. Nonetheless, emerging new COVID-19 variants are necessitating continuous research on vaccines, including these produced in plants, either via stable expression in transgenic or transplastomic plants or transient expression using viral vectors or agroinfection. Plant systems provide low cost, high scalability, safety and capacity to produce multimeric or glycosylated proteins. To date, from among CoVs antigens, spike and capsid proteins have been produced in plants, mostly using transient expression systems, at the additional advantage of rapid production. Immunogenicity of plant-produced CoVs proteins was positively evaluated after injection of purified antigens. However, this review indicates that plant-produced CoVs proteins or their carrier-fused immunodominant epitopes can be potentially applied also as mucosal vaccines, either after purification to be administered to particular membranes (nasal, bronchus mucosa) associated with the respiratory system, or as oral vaccines obtained from partly processed plant tissue. |
| first_indexed | 2024-03-09T20:54:14Z |
| format | Article |
| id | doaj.art-211bb10ce16e4a7eaf6a8c8293e6983b |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T20:54:14Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-211bb10ce16e4a7eaf6a8c8293e6983b2023-11-23T22:24:07ZengMDPI AGVaccines2076-393X2022-01-0110213810.3390/vaccines10020138Plant-Based Vaccines in Combat against Coronavirus DiseasesBenita Ortega-Berlanga0Tomasz Pniewski1Institute of Plant Genetics, Polish Academy of Sciences, Strzeszyńska 34, 60-479 Poznań, PolandInstitute of Plant Genetics, Polish Academy of Sciences, Strzeszyńska 34, 60-479 Poznań, PolandCoronavirus (CoV) diseases, including Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS) have gained in importance worldwide, especially with the current COVID-19 pandemic caused by SARS-CoV-2. Due to the huge global demand, various types of vaccines have been developed, such as more traditional attenuated or inactivated viruses, subunit and VLP-based vaccines, as well as novel DNA and RNA vaccines. Nonetheless, emerging new COVID-19 variants are necessitating continuous research on vaccines, including these produced in plants, either via stable expression in transgenic or transplastomic plants or transient expression using viral vectors or agroinfection. Plant systems provide low cost, high scalability, safety and capacity to produce multimeric or glycosylated proteins. To date, from among CoVs antigens, spike and capsid proteins have been produced in plants, mostly using transient expression systems, at the additional advantage of rapid production. Immunogenicity of plant-produced CoVs proteins was positively evaluated after injection of purified antigens. However, this review indicates that plant-produced CoVs proteins or their carrier-fused immunodominant epitopes can be potentially applied also as mucosal vaccines, either after purification to be administered to particular membranes (nasal, bronchus mucosa) associated with the respiratory system, or as oral vaccines obtained from partly processed plant tissue.https://www.mdpi.com/2076-393X/10/2/138coronavirusesCOVID-19MERS-CoVSARS-CoVbiopharmingplant-based vaccines |
| spellingShingle | Benita Ortega-Berlanga Tomasz Pniewski Plant-Based Vaccines in Combat against Coronavirus Diseases Vaccines coronaviruses COVID-19 MERS-CoV SARS-CoV biopharming plant-based vaccines |
| title | Plant-Based Vaccines in Combat against Coronavirus Diseases |
| title_full | Plant-Based Vaccines in Combat against Coronavirus Diseases |
| title_fullStr | Plant-Based Vaccines in Combat against Coronavirus Diseases |
| title_full_unstemmed | Plant-Based Vaccines in Combat against Coronavirus Diseases |
| title_short | Plant-Based Vaccines in Combat against Coronavirus Diseases |
| title_sort | plant based vaccines in combat against coronavirus diseases |
| topic | coronaviruses COVID-19 MERS-CoV SARS-CoV biopharming plant-based vaccines |
| url | https://www.mdpi.com/2076-393X/10/2/138 |
| work_keys_str_mv | AT benitaortegaberlanga plantbasedvaccinesincombatagainstcoronavirusdiseases AT tomaszpniewski plantbasedvaccinesincombatagainstcoronavirusdiseases |