Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Abstract Background Transferrin receptor (TfR1) mediated enhanced brain delivery of antibodies have been studied extensively in preclinical settings. However, the brain pharmacokinetics, i.e. brain entry, distribution and elimination are still not fully understood for this class of antibodies. The o...

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Bibliographic Details
Main Authors: Rebecca Faresjö, Gillian Bonvicini, Xiaotian T. Fang, Ximena Aguilar, Dag Sehlin, Stina Syvänen
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Fluids and Barriers of the CNS
Subjects:
Bispecific antibody
Brain pharmacokinetics
Transferrin receptor
BBB
Online Access:https://doi.org/10.1186/s12987-021-00257-0

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