Single blastocyst transfer: The key to reduce multiple pregnancy rates without compromising the live birth rate
Background: Historically, to achieve higher pregnancy rates, multiple embryos were transferred after an in-vitro fertilisation (IVF). However, this practice is being reassessed, because it leads to multiple pregnancies that is known to cause adverse maternal and fetal outcomes. Aim: To compare the p...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2017-01-01
|
| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2017;volume=10;issue=3;spage=201;epage=207;aulast=Sundhararaj |
| _version_ | 1819209971626147840 |
|---|---|
| author | Uma M Sundhararaj Monali V Madne Reeta Biliangady Sumana Gurunath Ambika G Swamy Indu S.T. Gopal |
| author_facet | Uma M Sundhararaj Monali V Madne Reeta Biliangady Sumana Gurunath Ambika G Swamy Indu S.T. Gopal |
| author_sort | Uma M Sundhararaj |
| collection | DOAJ |
| description | Background: Historically, to achieve higher pregnancy rates, multiple embryos were transferred after an in-vitro fertilisation (IVF). However, this practice is being reassessed, because it leads to multiple pregnancies that is known to cause adverse maternal and fetal outcomes. Aim: To compare the pregnancy outcomes in fresh IVF or intracytoplasmic sperm injection (ICSI) cycles among women undergoing elective single blastocyst transfer (eSBT) vs. those undergoing double blastocyst transfer (DBT). Settings and Design: It is a retrospective data analysis of 582 patients undergoing fresh IVF/ICSI cycles performed from January 2012 to June 2015. Materials and Methods: Patients, who underwent IVF/ICSI and developed more than one blastocyst, were included in the study. Donor cycles were excluded from the study. All the embryos were cultured to blastocyst stage in sequential media followed by transfer of two blastocysts (DBT) or eSBT and cryopreservation of the remaining. Statistical Analysis: Statistical analysis was performed using chi square test. Results: Out of 582 patients, in 149 patients one blastocyst was transferred and in 433 patients two blastocysts were transferred. There was no statistical difference in the biochemical pregnancy rate, clinical pregnancy rate and live birth rate in both the groups. Statistics demonstrated a significant drop in miscarriage rate in eSBT group. There was no incidence of twins in eSBT group, whereas twin birth rate per clinical pregnancy was 29.02% in DBT group. Conclusion: Single blastocyst transfer is an effective method to reduce the risk of multiple births without compromising the pregnancy outcomes. Given the promising potential of vitrification; the remaining blastocyst can be cryopreserved. |
| first_indexed | 2024-12-23T06:03:46Z |
| format | Article |
| id | doaj.art-211dbb9770f944d99403fee2b5ea4441 |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-12-23T06:03:46Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-211dbb9770f944d99403fee2b5ea44412022-12-21T17:57:36ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662017-01-0110320120710.4103/jhrs.JHRS_130_16Single blastocyst transfer: The key to reduce multiple pregnancy rates without compromising the live birth rateUma M SundhararajMonali V MadneReeta BiliangadySumana GurunathAmbika G SwamyIndu S.T. GopalBackground: Historically, to achieve higher pregnancy rates, multiple embryos were transferred after an in-vitro fertilisation (IVF). However, this practice is being reassessed, because it leads to multiple pregnancies that is known to cause adverse maternal and fetal outcomes. Aim: To compare the pregnancy outcomes in fresh IVF or intracytoplasmic sperm injection (ICSI) cycles among women undergoing elective single blastocyst transfer (eSBT) vs. those undergoing double blastocyst transfer (DBT). Settings and Design: It is a retrospective data analysis of 582 patients undergoing fresh IVF/ICSI cycles performed from January 2012 to June 2015. Materials and Methods: Patients, who underwent IVF/ICSI and developed more than one blastocyst, were included in the study. Donor cycles were excluded from the study. All the embryos were cultured to blastocyst stage in sequential media followed by transfer of two blastocysts (DBT) or eSBT and cryopreservation of the remaining. Statistical Analysis: Statistical analysis was performed using chi square test. Results: Out of 582 patients, in 149 patients one blastocyst was transferred and in 433 patients two blastocysts were transferred. There was no statistical difference in the biochemical pregnancy rate, clinical pregnancy rate and live birth rate in both the groups. Statistics demonstrated a significant drop in miscarriage rate in eSBT group. There was no incidence of twins in eSBT group, whereas twin birth rate per clinical pregnancy was 29.02% in DBT group. Conclusion: Single blastocyst transfer is an effective method to reduce the risk of multiple births without compromising the pregnancy outcomes. Given the promising potential of vitrification; the remaining blastocyst can be cryopreserved.http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2017;volume=10;issue=3;spage=201;epage=207;aulast=SundhararajCryopreservationdouble blastocyst transferelective single blastocyst transferin vitro fertilisationmiscarriagemultiple pregnancy |
| spellingShingle | Uma M Sundhararaj Monali V Madne Reeta Biliangady Sumana Gurunath Ambika G Swamy Indu S.T. Gopal Single blastocyst transfer: The key to reduce multiple pregnancy rates without compromising the live birth rate Journal of Human Reproductive Sciences Cryopreservation double blastocyst transfer elective single blastocyst transfer in vitro fertilisation miscarriage multiple pregnancy |
| title | Single blastocyst transfer: The key to reduce multiple pregnancy rates without compromising the live birth rate |
| title_full | Single blastocyst transfer: The key to reduce multiple pregnancy rates without compromising the live birth rate |
| title_fullStr | Single blastocyst transfer: The key to reduce multiple pregnancy rates without compromising the live birth rate |
| title_full_unstemmed | Single blastocyst transfer: The key to reduce multiple pregnancy rates without compromising the live birth rate |
| title_short | Single blastocyst transfer: The key to reduce multiple pregnancy rates without compromising the live birth rate |
| title_sort | single blastocyst transfer the key to reduce multiple pregnancy rates without compromising the live birth rate |
| topic | Cryopreservation double blastocyst transfer elective single blastocyst transfer in vitro fertilisation miscarriage multiple pregnancy |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2017;volume=10;issue=3;spage=201;epage=207;aulast=Sundhararaj |
| work_keys_str_mv | AT umamsundhararaj singleblastocysttransferthekeytoreducemultiplepregnancyrateswithoutcompromisingthelivebirthrate AT monalivmadne singleblastocysttransferthekeytoreducemultiplepregnancyrateswithoutcompromisingthelivebirthrate AT reetabiliangady singleblastocysttransferthekeytoreducemultiplepregnancyrateswithoutcompromisingthelivebirthrate AT sumanagurunath singleblastocysttransferthekeytoreducemultiplepregnancyrateswithoutcompromisingthelivebirthrate AT ambikagswamy singleblastocysttransferthekeytoreducemultiplepregnancyrateswithoutcompromisingthelivebirthrate AT industgopal singleblastocysttransferthekeytoreducemultiplepregnancyrateswithoutcompromisingthelivebirthrate |