3D-printing magnesium–polycaprolactone loaded with melatonin inhibits the development of osteosarcoma by regulating cell-in-cell structures

3D-printing magnesium–polycaprolactone loaded with melatonin inhibits the development of osteosarcoma by regulating cell-in-cell structures

Abstract Melatonin has been proposed as a potent anticarcinogen presents a short half-life for osteosarcoma (OS). Cell-in-cell (CIC) structures play a role in the development of malignant tumors by changing the tumor cell energy metabolism. This study developed a melatonin-loaded 3D printed magnesiu...

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Bibliographic Details
Main Authors: Weilin Zhang, Wei Zhao, Qin Li, Duoyi Zhao, Junxing Qu, Ziyang Yuan, Zhihong Cheng, Xiaojuan Zhu, Xiuli Zhuang, Zhiyu Zhang
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Nanobiotechnology
Subjects:
Osteosarcoma
Melatonin
Cell-in-cell
Mg–PCL
Rho/ROCK
cAMP/PKA signaling pathway
Online Access:https://doi.org/10.1186/s12951-021-01012-1

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