Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer
<p>Abstract</p> <p>Background</p> <p>The VEGF family of ligands and receptors are intimately involved in tumor angiogenesis, lymphangiogenesis and metastasis. The evaluation of VEGF ligand/receptor ratios may provide a more profound understanding of the involvement of t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-03-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/10/93 |
| _version_ | 1811315383203790848 |
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| author | Terracciano Luigi Baumhoer Daniel Zlobec Inti Eppenberger Manuela Lugli Alessandro |
| author_facet | Terracciano Luigi Baumhoer Daniel Zlobec Inti Eppenberger Manuela Lugli Alessandro |
| author_sort | Terracciano Luigi |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The VEGF family of ligands and receptors are intimately involved in tumor angiogenesis, lymphangiogenesis and metastasis. The evaluation of VEGF ligand/receptor ratios may provide a more profound understanding of the involvement of these proteins in colorectal tumour progression. The aim of this study was to elucidate the role of the VEGF ligand/receptor ratios on tumour progression and metastasis in patients with mismatch repair-proficient colorectal cancer.</p> <p>Methods</p> <p>Immunohistochemistry for VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGFR1, VEGFR2 and VEGF3 was carried out on 387 mismatch repair-proficient colorectal cancers using a tissue microarray. Evaluation of immunoreactivity was performed semi-quantitatively and the ligand/receptor expression ratio was obtained.</p> <p>Results</p> <p>An increased VEGF-A/VEGFR1 ratio, VEGF-A and VEGFR1 was linked to the presence of peritumoral lymphocytic inflammation at the invasive front (p = 0.032; p = 0.005; p = 0.032, respectively). VEGFR1 expression was related to poorer outcome in multivariable analysis with pT stage, pN stage, vascular invasion, and post-operative therapy. A higher ratio of VEGF-A/VEGFR2 was linked to advanced TNM stage (p = 0.005) while VEGF-A and VEGFR2 were elevated in tumours with an infiltrating tumour growth pattern (p = 0.006; p = 0.014; p = 0.006). No effect of VEGF-A/VEGFR2, VEGF-A or VEGFR2 on survival time was noted.</p> <p>Conclusions</p> <p>Our findings highlight an involvement of VEGF-A, VEGR1 and VEGFR2 in events occurring at the invasive tumour front and a potential prognostic role of VEGFR1 expression in mismatch repair-proficient colorectal cancers. The VEGF-A ligand to VEGFR1 or VEGFR2 ratio may represent an alternative evaluation system for identifying patients with poorer clinical outcome.</p> |
| first_indexed | 2024-04-13T11:29:22Z |
| format | Article |
| id | doaj.art-212051db2f42405c894166ccd5e187cb |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-13T11:29:22Z |
| publishDate | 2010-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-212051db2f42405c894166ccd5e187cb2022-12-22T02:48:36ZengBMCBMC Cancer1471-24072010-03-011019310.1186/1471-2407-10-93Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancerTerracciano LuigiBaumhoer DanielZlobec IntiEppenberger ManuelaLugli Alessandro<p>Abstract</p> <p>Background</p> <p>The VEGF family of ligands and receptors are intimately involved in tumor angiogenesis, lymphangiogenesis and metastasis. The evaluation of VEGF ligand/receptor ratios may provide a more profound understanding of the involvement of these proteins in colorectal tumour progression. The aim of this study was to elucidate the role of the VEGF ligand/receptor ratios on tumour progression and metastasis in patients with mismatch repair-proficient colorectal cancer.</p> <p>Methods</p> <p>Immunohistochemistry for VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGFR1, VEGFR2 and VEGF3 was carried out on 387 mismatch repair-proficient colorectal cancers using a tissue microarray. Evaluation of immunoreactivity was performed semi-quantitatively and the ligand/receptor expression ratio was obtained.</p> <p>Results</p> <p>An increased VEGF-A/VEGFR1 ratio, VEGF-A and VEGFR1 was linked to the presence of peritumoral lymphocytic inflammation at the invasive front (p = 0.032; p = 0.005; p = 0.032, respectively). VEGFR1 expression was related to poorer outcome in multivariable analysis with pT stage, pN stage, vascular invasion, and post-operative therapy. A higher ratio of VEGF-A/VEGFR2 was linked to advanced TNM stage (p = 0.005) while VEGF-A and VEGFR2 were elevated in tumours with an infiltrating tumour growth pattern (p = 0.006; p = 0.014; p = 0.006). No effect of VEGF-A/VEGFR2, VEGF-A or VEGFR2 on survival time was noted.</p> <p>Conclusions</p> <p>Our findings highlight an involvement of VEGF-A, VEGR1 and VEGFR2 in events occurring at the invasive tumour front and a potential prognostic role of VEGFR1 expression in mismatch repair-proficient colorectal cancers. The VEGF-A ligand to VEGFR1 or VEGFR2 ratio may represent an alternative evaluation system for identifying patients with poorer clinical outcome.</p>http://www.biomedcentral.com/1471-2407/10/93 |
| spellingShingle | Terracciano Luigi Baumhoer Daniel Zlobec Inti Eppenberger Manuela Lugli Alessandro Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer BMC Cancer |
| title | Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer |
| title_full | Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer |
| title_fullStr | Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer |
| title_full_unstemmed | Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer |
| title_short | Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer |
| title_sort | role of the vegf ligand to receptor ratio in the progression of mismatch repair proficient colorectal cancer |
| url | http://www.biomedcentral.com/1471-2407/10/93 |
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