Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
The tau protein has been implicated in neurodegenerative disorders and can propagate from cell to cell. Here, the authors show that tau acetylation reduces its degradation by chaperone-mediated autophagy, causing re-routing to other autophagic pathways and increasing extracellular tau release.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22501-9 |
| _version_ | 1818857648440737792 |
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| author | Benjamin Caballero Mathieu Bourdenx Enrique Luengo Antonio Diaz Peter Dongmin Sohn Xu Chen Chao Wang Yves R. Juste Susanne Wegmann Bindi Patel Zapporah T. Young Szu Yu Kuo Jose Antonio Rodriguez-Navarro Hao Shao Manuela G. Lopez Celeste M. Karch Alison M. Goate Jason E. Gestwicki Bradley T. Hyman Li Gan Ana Maria Cuervo |
| author_facet | Benjamin Caballero Mathieu Bourdenx Enrique Luengo Antonio Diaz Peter Dongmin Sohn Xu Chen Chao Wang Yves R. Juste Susanne Wegmann Bindi Patel Zapporah T. Young Szu Yu Kuo Jose Antonio Rodriguez-Navarro Hao Shao Manuela G. Lopez Celeste M. Karch Alison M. Goate Jason E. Gestwicki Bradley T. Hyman Li Gan Ana Maria Cuervo |
| author_sort | Benjamin Caballero |
| collection | DOAJ |
| description | The tau protein has been implicated in neurodegenerative disorders and can propagate from cell to cell. Here, the authors show that tau acetylation reduces its degradation by chaperone-mediated autophagy, causing re-routing to other autophagic pathways and increasing extracellular tau release. |
| first_indexed | 2024-12-19T08:43:44Z |
| format | Article |
| id | doaj.art-212054e33af24b80a55cb5e3dd710b36 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:43:44Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-212054e33af24b80a55cb5e3dd710b362022-12-21T20:28:51ZengNature PortfolioNature Communications2041-17232021-04-0112111810.1038/s41467-021-22501-9Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in miceBenjamin Caballero0Mathieu Bourdenx1Enrique Luengo2Antonio Diaz3Peter Dongmin Sohn4Xu Chen5Chao Wang6Yves R. Juste7Susanne Wegmann8Bindi Patel9Zapporah T. Young10Szu Yu Kuo11Jose Antonio Rodriguez-Navarro12Hao Shao13Manuela G. Lopez14Celeste M. Karch15Alison M. Goate16Jason E. Gestwicki17Bradley T. Hyman18Li Gan19Ana Maria Cuervo20Department of Developmental and Molecular Biology, Albert Einstein College of MedicineDepartment of Developmental and Molecular Biology, Albert Einstein College of MedicineDepartment of Developmental and Molecular Biology, Albert Einstein College of MedicineDepartment of Developmental and Molecular Biology, Albert Einstein College of MedicineHelen and Robert Appel Alzheimer’s Disease Research Institute, Weill Cornell MedicineHelen and Robert Appel Alzheimer’s Disease Research Institute, Weill Cornell MedicineHelen and Robert Appel Alzheimer’s Disease Research Institute, Weill Cornell MedicineDepartment of Developmental and Molecular Biology, Albert Einstein College of MedicineMassachusetts General Hospital, Harvard Medical SchoolDepartment of Developmental and Molecular Biology, Albert Einstein College of MedicineInstitute for Neurodegenerative Disease, University of California at San FranciscoInstitute for Neurodegenerative Disease, University of California at San FranciscoDepartment of Developmental and Molecular Biology, Albert Einstein College of MedicineInstitute for Neurodegenerative Disease, University of California at San FranciscoInstitute Teofilo Hernando for Drug Discovery, Department of Pharmacology, School of Medicine, Universidad Autonoma de MadridDepartment of Psychiatry, Washington UniversityDepartment of Neuroscience, Icahn School of Medicine at Mount SinaiInstitute for Neurodegenerative Disease, University of California at San FranciscoMassachusetts General Hospital, Harvard Medical SchoolHelen and Robert Appel Alzheimer’s Disease Research Institute, Weill Cornell MedicineDepartment of Developmental and Molecular Biology, Albert Einstein College of MedicineThe tau protein has been implicated in neurodegenerative disorders and can propagate from cell to cell. Here, the authors show that tau acetylation reduces its degradation by chaperone-mediated autophagy, causing re-routing to other autophagic pathways and increasing extracellular tau release.https://doi.org/10.1038/s41467-021-22501-9 |
| spellingShingle | Benjamin Caballero Mathieu Bourdenx Enrique Luengo Antonio Diaz Peter Dongmin Sohn Xu Chen Chao Wang Yves R. Juste Susanne Wegmann Bindi Patel Zapporah T. Young Szu Yu Kuo Jose Antonio Rodriguez-Navarro Hao Shao Manuela G. Lopez Celeste M. Karch Alison M. Goate Jason E. Gestwicki Bradley T. Hyman Li Gan Ana Maria Cuervo Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice Nature Communications |
| title | Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice |
| title_full | Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice |
| title_fullStr | Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice |
| title_full_unstemmed | Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice |
| title_short | Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice |
| title_sort | acetylated tau inhibits chaperone mediated autophagy and promotes tau pathology propagation in mice |
| url | https://doi.org/10.1038/s41467-021-22501-9 |
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