The role of cystatin C, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the evaluation of kidney function in women with preeclampsia
Objective: We aimed to compare the diagnostic efficiency of cystatin C with traditional kidney markers in preeclampsia and to evaluate the relationship of these markers with neutrophil-lymphocyte and thrombocyte-lymphocyte ratios. Materials and methods: 14 severe preeclampsia, 48 mild preeclampsia a...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-07-01
|
| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455921001194 |
| _version_ | 1818665819122434048 |
|---|---|
| author | Aysun Tekeli Taşkömür Özlem Erten |
| author_facet | Aysun Tekeli Taşkömür Özlem Erten |
| author_sort | Aysun Tekeli Taşkömür |
| collection | DOAJ |
| description | Objective: We aimed to compare the diagnostic efficiency of cystatin C with traditional kidney markers in preeclampsia and to evaluate the relationship of these markers with neutrophil-lymphocyte and thrombocyte-lymphocyte ratios. Materials and methods: 14 severe preeclampsia, 48 mild preeclampsia and 79 patients with healthy pregnancy who presented to our obstetrics and gynecology clinic within one year were compared. These three groups were compared in terms of demographic characteristics, physical findings, serum urea, creatinine, cystatin C levels, and neutrophil-lymphocyte and platelet-lymphocyte ratios. Results: The mean serum cystatin C, creatinine and uric acid levels were higher in the severe preeclampsia group compared with the mild preeclamptic and healthy pregnancies (p < 0.001). While cystatin C values increased as the week of gestation increased in the mild preeclampsia group, there was no relation with the gestational week in the control group and the severe preeclampsia group. However, the highest cystatin C values were in the severe preeclampsia group, regardless of the week (p < 0.05). The area under the ROC curve was statistically significant for cystatin C, uric acid and creatinine, but of these three values, cystatin C had the highest sensitivity and specificity. Neutrophil-lymphocyte ratio (NLR) was significantly higher in the severe preeclampsia group than healthy pregnancies, but the level was not significant compared to mild preeclampsia. There was no difference between the groups in terms of platelet-lymphocyte ratio. Conclusion: It can be suggested that cystatin C level reflects renal functions better than uric acid and creatinine in preeclampsia. Cystatin C can be used as a prognostic marker in preeclamptic pregnancies, and rising levels may be valuable for predicting severe preeclampsia. Especially with advancing gestational week, the increase in cystatin C level may indicate an association with the development of preeclampsia. NLR levels may be a parameter correlating with severity in severe preeclampsia. |
| first_indexed | 2024-12-17T05:54:41Z |
| format | Article |
| id | doaj.art-2121b434c8d04e28b3100dba662fedc3 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-17T05:54:41Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-2121b434c8d04e28b3100dba662fedc32022-12-21T22:01:04ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592021-07-01604615620The role of cystatin C, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the evaluation of kidney function in women with preeclampsiaAysun Tekeli Taşkömür0Özlem Erten1Amasya University Sabuncuoğlu Şerefeddin Education and Research Hospital, Gynecology and Obstetrics Clinic, Amasya, Turkey; Corresponding author. Kirazlıdere Neighborhood Turgut Özal Street, Amasya, Turkey. Fax: +0 358 212 00 01.Kütahya University of Health Sciences Faculty of Medicine, Department of Gynecology and Obstetrics, Kütahya, TurkeyObjective: We aimed to compare the diagnostic efficiency of cystatin C with traditional kidney markers in preeclampsia and to evaluate the relationship of these markers with neutrophil-lymphocyte and thrombocyte-lymphocyte ratios. Materials and methods: 14 severe preeclampsia, 48 mild preeclampsia and 79 patients with healthy pregnancy who presented to our obstetrics and gynecology clinic within one year were compared. These three groups were compared in terms of demographic characteristics, physical findings, serum urea, creatinine, cystatin C levels, and neutrophil-lymphocyte and platelet-lymphocyte ratios. Results: The mean serum cystatin C, creatinine and uric acid levels were higher in the severe preeclampsia group compared with the mild preeclamptic and healthy pregnancies (p < 0.001). While cystatin C values increased as the week of gestation increased in the mild preeclampsia group, there was no relation with the gestational week in the control group and the severe preeclampsia group. However, the highest cystatin C values were in the severe preeclampsia group, regardless of the week (p < 0.05). The area under the ROC curve was statistically significant for cystatin C, uric acid and creatinine, but of these three values, cystatin C had the highest sensitivity and specificity. Neutrophil-lymphocyte ratio (NLR) was significantly higher in the severe preeclampsia group than healthy pregnancies, but the level was not significant compared to mild preeclampsia. There was no difference between the groups in terms of platelet-lymphocyte ratio. Conclusion: It can be suggested that cystatin C level reflects renal functions better than uric acid and creatinine in preeclampsia. Cystatin C can be used as a prognostic marker in preeclamptic pregnancies, and rising levels may be valuable for predicting severe preeclampsia. Especially with advancing gestational week, the increase in cystatin C level may indicate an association with the development of preeclampsia. NLR levels may be a parameter correlating with severity in severe preeclampsia.http://www.sciencedirect.com/science/article/pii/S1028455921001194Cystatin CNeutrophil-lymphocyte ratioPlatelet-lymphocyte ratioPreeclampsiaRenal function |
| spellingShingle | Aysun Tekeli Taşkömür Özlem Erten The role of cystatin C, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the evaluation of kidney function in women with preeclampsia Taiwanese Journal of Obstetrics & Gynecology Cystatin C Neutrophil-lymphocyte ratio Platelet-lymphocyte ratio Preeclampsia Renal function |
| title | The role of cystatin C, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the evaluation of kidney function in women with preeclampsia |
| title_full | The role of cystatin C, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the evaluation of kidney function in women with preeclampsia |
| title_fullStr | The role of cystatin C, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the evaluation of kidney function in women with preeclampsia |
| title_full_unstemmed | The role of cystatin C, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the evaluation of kidney function in women with preeclampsia |
| title_short | The role of cystatin C, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the evaluation of kidney function in women with preeclampsia |
| title_sort | role of cystatin c neutrophil lymphocyte ratio and platelet lymphocyte ratio in the evaluation of kidney function in women with preeclampsia |
| topic | Cystatin C Neutrophil-lymphocyte ratio Platelet-lymphocyte ratio Preeclampsia Renal function |
| url | http://www.sciencedirect.com/science/article/pii/S1028455921001194 |
| work_keys_str_mv | AT aysuntekelitaskomur theroleofcystatincneutrophillymphocyteratioandplateletlymphocyteratiointheevaluationofkidneyfunctioninwomenwithpreeclampsia AT ozlemerten theroleofcystatincneutrophillymphocyteratioandplateletlymphocyteratiointheevaluationofkidneyfunctioninwomenwithpreeclampsia AT aysuntekelitaskomur roleofcystatincneutrophillymphocyteratioandplateletlymphocyteratiointheevaluationofkidneyfunctioninwomenwithpreeclampsia AT ozlemerten roleofcystatincneutrophillymphocyteratioandplateletlymphocyteratiointheevaluationofkidneyfunctioninwomenwithpreeclampsia |