Targeting Cell Entry of Enveloped Viruses as an Antiviral Strategy
The entry of enveloped viruses into their host cells involves several successive steps, each one being amenable to therapeutic intervention. Entry inhibitors act by targeting viral and/or cellular components, through either the inhibition of protein-protein interactions within the viral envelope pro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/16/1/221/ |
| _version_ | 1818232821885435904 |
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| author | Elodie Teissier François Penin Eve-Isabelle Pécheur |
| author_facet | Elodie Teissier François Penin Eve-Isabelle Pécheur |
| author_sort | Elodie Teissier |
| collection | DOAJ |
| description | The entry of enveloped viruses into their host cells involves several successive steps, each one being amenable to therapeutic intervention. Entry inhibitors act by targeting viral and/or cellular components, through either the inhibition of protein-protein interactions within the viral envelope proteins or between viral proteins and host cell receptors, or through the inhibition of protein-lipid interactions. Interestingly, inhibitors that concentrate into/onto the membrane in order to target a protein involved in the entry process, such as arbidol or peptide inhibitors of the human immunodeficiency virus (HIV), could allow the use of doses compatible with therapeutic requirements. The efficacy of these drugs validates entry as a point of intervention in viral life cycles. Strategies based upon small molecule antiviral agents, peptides, proteins or nucleic acids, would most likely prove efficient in multidrug combinations, in order to inhibit several steps of virus life cycle and prevent disease progression. |
| first_indexed | 2024-12-12T11:12:23Z |
| format | Article |
| id | doaj.art-21223be92d8242c6a656ba27f5c7ab03 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T11:12:23Z |
| publishDate | 2010-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-21223be92d8242c6a656ba27f5c7ab032022-12-22T00:26:16ZengMDPI AGMolecules1420-30492010-12-0116122125010.3390/molecules16010221Targeting Cell Entry of Enveloped Viruses as an Antiviral StrategyElodie TeissierFrançois PeninEve-Isabelle PécheurThe entry of enveloped viruses into their host cells involves several successive steps, each one being amenable to therapeutic intervention. Entry inhibitors act by targeting viral and/or cellular components, through either the inhibition of protein-protein interactions within the viral envelope proteins or between viral proteins and host cell receptors, or through the inhibition of protein-lipid interactions. Interestingly, inhibitors that concentrate into/onto the membrane in order to target a protein involved in the entry process, such as arbidol or peptide inhibitors of the human immunodeficiency virus (HIV), could allow the use of doses compatible with therapeutic requirements. The efficacy of these drugs validates entry as a point of intervention in viral life cycles. Strategies based upon small molecule antiviral agents, peptides, proteins or nucleic acids, would most likely prove efficient in multidrug combinations, in order to inhibit several steps of virus life cycle and prevent disease progression.http://www.mdpi.com/1420-3049/16/1/221/inhibitorsviral entryenveloped virus |
| spellingShingle | Elodie Teissier François Penin Eve-Isabelle Pécheur Targeting Cell Entry of Enveloped Viruses as an Antiviral Strategy Molecules inhibitors viral entry enveloped virus |
| title | Targeting Cell Entry of Enveloped Viruses as an Antiviral Strategy |
| title_full | Targeting Cell Entry of Enveloped Viruses as an Antiviral Strategy |
| title_fullStr | Targeting Cell Entry of Enveloped Viruses as an Antiviral Strategy |
| title_full_unstemmed | Targeting Cell Entry of Enveloped Viruses as an Antiviral Strategy |
| title_short | Targeting Cell Entry of Enveloped Viruses as an Antiviral Strategy |
| title_sort | targeting cell entry of enveloped viruses as an antiviral strategy |
| topic | inhibitors viral entry enveloped virus |
| url | http://www.mdpi.com/1420-3049/16/1/221/ |
| work_keys_str_mv | AT elodieteissier targetingcellentryofenvelopedvirusesasanantiviralstrategy AT francoispenin targetingcellentryofenvelopedvirusesasanantiviralstrategy AT eveisabellepecheur targetingcellentryofenvelopedvirusesasanantiviralstrategy |