Synthesis, Characterization, Computational and Biological Activity of Some Schiff Bases and Their Fe, Cu and Zn Complexes
Four new symmetrical Schiff bases derived from 2,2′-diamino-6,6′-dibromo-4,4′-dimethyl-1,1′-biphenyl or 2,2′-diamino-4,4′-dimethyl-1,1′-biphenyl, and 3,5-dichloro- or 5-nitro-salicylaldehyde, were synthesized and reacted with copper-, iron- and zinc-acetate, producing the corresponding complexes. Th...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Inorganics |
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| Online Access: | https://www.mdpi.com/2304-6740/10/8/112 |
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| author | Tareq M. A. Al-Shboul Mohammad El-khateeb Zaid H. Obeidat Taher S. Ababneh Suha S. Al-Tarawneh Mazhar S. Al Zoubi Walhan Alshaer Anas Abu Seni Taqwa Qasem Hayato Moriyama Yukihiro Yoshida Hiroshi Kitagawa Taghreed M. A. Jazzazi |
| author_facet | Tareq M. A. Al-Shboul Mohammad El-khateeb Zaid H. Obeidat Taher S. Ababneh Suha S. Al-Tarawneh Mazhar S. Al Zoubi Walhan Alshaer Anas Abu Seni Taqwa Qasem Hayato Moriyama Yukihiro Yoshida Hiroshi Kitagawa Taghreed M. A. Jazzazi |
| author_sort | Tareq M. A. Al-Shboul |
| collection | DOAJ |
| description | Four new symmetrical Schiff bases derived from 2,2′-diamino-6,6′-dibromo-4,4′-dimethyl-1,1′-biphenyl or 2,2′-diamino-4,4′-dimethyl-1,1′-biphenyl, and 3,5-dichloro- or 5-nitro-salicylaldehyde, were synthesized and reacted with copper-, iron- and zinc-acetate, producing the corresponding complexes. The Schiff bases and their metal complexes were characterized by <sup>1</sup>H-, <sup>13</sup>C-NMR, IR and UV-Vis spectroscopy and elemental analysis. The structures of one Schiff base and the two zinc complexes were resolved by X-ray structure determination. Density functional theory (DFT) calculations at the B3LYP/6-31G(d) level of the latter compounds were carried out to optimize and examine their molecular geometries. The biomedical applications of the Schiff bases and their complexes were investigated as anticancer or antimicrobial agents. |
| first_indexed | 2024-03-09T13:13:45Z |
| format | Article |
| id | doaj.art-2123a49f7a0e4c758424c712d665a471 |
| institution | Directory Open Access Journal |
| issn | 2304-6740 |
| language | English |
| last_indexed | 2024-03-09T13:13:45Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj.art-2123a49f7a0e4c758424c712d665a4712023-11-30T21:38:33ZengMDPI AGInorganics2304-67402022-08-0110811210.3390/inorganics10080112Synthesis, Characterization, Computational and Biological Activity of Some Schiff Bases and Their Fe, Cu and Zn ComplexesTareq M. A. Al-Shboul0Mohammad El-khateeb1Zaid H. Obeidat2Taher S. Ababneh3Suha S. Al-Tarawneh4Mazhar S. Al Zoubi5Walhan Alshaer6Anas Abu Seni7Taqwa Qasem8Hayato Moriyama9Yukihiro Yoshida10Hiroshi Kitagawa11Taghreed M. A. Jazzazi12Department of Chemistry and Chemical Technology, Tafila Technical University, Tafila 66110, JordanChemistry Department, Jordan University of Science and Technology, Irbid 22110, JordanDepartment of Chemistry, Yarmouk University, Irbid 21163, JordanDepartment of Chemistry, Yarmouk University, Irbid 21163, JordanDepartment of Chemistry and Chemical Technology, Tafila Technical University, Tafila 66110, JordanDepartment of Basic Medical Sciences, Yarmouk University, Irbid 21163, JordanCell Therapy Center, The University of Jordan, Amman 11942, JordanDepartment of Chemistry, Yarmouk University, Irbid 21163, JordanDepartment of Basic Medical Sciences, Yarmouk University, Irbid 21163, JordanDivision of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, JapanDivision of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, JapanDivision of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, JapanDepartment of Chemistry, Yarmouk University, Irbid 21163, JordanFour new symmetrical Schiff bases derived from 2,2′-diamino-6,6′-dibromo-4,4′-dimethyl-1,1′-biphenyl or 2,2′-diamino-4,4′-dimethyl-1,1′-biphenyl, and 3,5-dichloro- or 5-nitro-salicylaldehyde, were synthesized and reacted with copper-, iron- and zinc-acetate, producing the corresponding complexes. The Schiff bases and their metal complexes were characterized by <sup>1</sup>H-, <sup>13</sup>C-NMR, IR and UV-Vis spectroscopy and elemental analysis. The structures of one Schiff base and the two zinc complexes were resolved by X-ray structure determination. Density functional theory (DFT) calculations at the B3LYP/6-31G(d) level of the latter compounds were carried out to optimize and examine their molecular geometries. The biomedical applications of the Schiff bases and their complexes were investigated as anticancer or antimicrobial agents.https://www.mdpi.com/2304-6740/10/8/112symmetrical Schiff basemetal complexescrystal structureanticancerantimicrobialDFT calculation |
| spellingShingle | Tareq M. A. Al-Shboul Mohammad El-khateeb Zaid H. Obeidat Taher S. Ababneh Suha S. Al-Tarawneh Mazhar S. Al Zoubi Walhan Alshaer Anas Abu Seni Taqwa Qasem Hayato Moriyama Yukihiro Yoshida Hiroshi Kitagawa Taghreed M. A. Jazzazi Synthesis, Characterization, Computational and Biological Activity of Some Schiff Bases and Their Fe, Cu and Zn Complexes Inorganics symmetrical Schiff base metal complexes crystal structure anticancer antimicrobial DFT calculation |
| title | Synthesis, Characterization, Computational and Biological Activity of Some Schiff Bases and Their Fe, Cu and Zn Complexes |
| title_full | Synthesis, Characterization, Computational and Biological Activity of Some Schiff Bases and Their Fe, Cu and Zn Complexes |
| title_fullStr | Synthesis, Characterization, Computational and Biological Activity of Some Schiff Bases and Their Fe, Cu and Zn Complexes |
| title_full_unstemmed | Synthesis, Characterization, Computational and Biological Activity of Some Schiff Bases and Their Fe, Cu and Zn Complexes |
| title_short | Synthesis, Characterization, Computational and Biological Activity of Some Schiff Bases and Their Fe, Cu and Zn Complexes |
| title_sort | synthesis characterization computational and biological activity of some schiff bases and their fe cu and zn complexes |
| topic | symmetrical Schiff base metal complexes crystal structure anticancer antimicrobial DFT calculation |
| url | https://www.mdpi.com/2304-6740/10/8/112 |
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