Algicidal Activity of Bacillamide Alkaloids and Their Analogues against Marine and Freshwater Harmful Algae
Harmful algal blooms have become a great challenge to global aquatic ecosystems over the past decades. Given their low toxicity, high selectivity, and environment-friendly properties, the use of natural products and their analogues as algicides has proven to be particularly efficient. In the present...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-08-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/15/8/247 |
| _version_ | 1818015493831786496 |
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| author | Bo Wang Yuanyuan Tao Qisheng Liu Na Liu Zhong Jin Xiaohua Xu |
| author_facet | Bo Wang Yuanyuan Tao Qisheng Liu Na Liu Zhong Jin Xiaohua Xu |
| author_sort | Bo Wang |
| collection | DOAJ |
| description | Harmful algal blooms have become a great challenge to global aquatic ecosystems over the past decades. Given their low toxicity, high selectivity, and environment-friendly properties, the use of natural products and their analogues as algicides has proven to be particularly efficient. In the present study, algicidal activity of naturally occurring bacillamides A–C, alkaloid (1), and neobacillamide A, as well as their synthetic analogues were investigated intensively. Bioassay results showed that, relative to natural bacillamide alkaloids, aniline-derived analogue (10d) exhibited higher algicidal potential against three freshwater harmful algae Mycrocyctis aeruginosa, Scenedesmus obliquus, and Chlorella pyrenoidosa, suggesting that it could be used as a promising lead compound to develop novel algicide for controlling harmful algal blooms. |
| first_indexed | 2024-04-14T06:57:46Z |
| format | Article |
| id | doaj.art-2128703536af4d4980d0f2242d1d7127 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T06:57:46Z |
| publishDate | 2017-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-2128703536af4d4980d0f2242d1d71272022-12-22T02:06:50ZengMDPI AGMarine Drugs1660-33972017-08-0115824710.3390/md15080247md15080247Algicidal Activity of Bacillamide Alkaloids and Their Analogues against Marine and Freshwater Harmful AlgaeBo Wang0Yuanyuan Tao1Qisheng Liu2Na Liu3Zhong Jin4Xiaohua Xu5State Key Laboratory of Elementoorganic Chemistry, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Elementoorganic Chemistry, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Elementoorganic Chemistry, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Elementoorganic Chemistry, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Elementoorganic Chemistry, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Elementoorganic Chemistry, Nankai University, Tianjin 300071, ChinaHarmful algal blooms have become a great challenge to global aquatic ecosystems over the past decades. Given their low toxicity, high selectivity, and environment-friendly properties, the use of natural products and their analogues as algicides has proven to be particularly efficient. In the present study, algicidal activity of naturally occurring bacillamides A–C, alkaloid (1), and neobacillamide A, as well as their synthetic analogues were investigated intensively. Bioassay results showed that, relative to natural bacillamide alkaloids, aniline-derived analogue (10d) exhibited higher algicidal potential against three freshwater harmful algae Mycrocyctis aeruginosa, Scenedesmus obliquus, and Chlorella pyrenoidosa, suggesting that it could be used as a promising lead compound to develop novel algicide for controlling harmful algal blooms.https://www.mdpi.com/1660-3397/15/8/247algicidebacillamidethiazolamidealleopathy |
| spellingShingle | Bo Wang Yuanyuan Tao Qisheng Liu Na Liu Zhong Jin Xiaohua Xu Algicidal Activity of Bacillamide Alkaloids and Their Analogues against Marine and Freshwater Harmful Algae Marine Drugs algicide bacillamide thiazolamide alleopathy |
| title | Algicidal Activity of Bacillamide Alkaloids and Their Analogues against Marine and Freshwater Harmful Algae |
| title_full | Algicidal Activity of Bacillamide Alkaloids and Their Analogues against Marine and Freshwater Harmful Algae |
| title_fullStr | Algicidal Activity of Bacillamide Alkaloids and Their Analogues against Marine and Freshwater Harmful Algae |
| title_full_unstemmed | Algicidal Activity of Bacillamide Alkaloids and Their Analogues against Marine and Freshwater Harmful Algae |
| title_short | Algicidal Activity of Bacillamide Alkaloids and Their Analogues against Marine and Freshwater Harmful Algae |
| title_sort | algicidal activity of bacillamide alkaloids and their analogues against marine and freshwater harmful algae |
| topic | algicide bacillamide thiazolamide alleopathy |
| url | https://www.mdpi.com/1660-3397/15/8/247 |
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