The Role of the NF-kB Pathway in Intracranial Aneurysms
The pathophysiology of intracranial aneurysms (IA) has been proven to be closely linked to hemodynamic stress and inflammatory pathways, most notably the NF-kB pathway. Therefore, it is a potential target for therapeutic intervention. In the present review, we investigated alterations in the vascula...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/12/1660 |
| _version_ | 1797381786003570688 |
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| author | Laurentiu Andrei Blaj Andrei Ionut Cucu Bogdan Ionel Tamba Mihaela Dana Turliuc |
| author_facet | Laurentiu Andrei Blaj Andrei Ionut Cucu Bogdan Ionel Tamba Mihaela Dana Turliuc |
| author_sort | Laurentiu Andrei Blaj |
| collection | DOAJ |
| description | The pathophysiology of intracranial aneurysms (IA) has been proven to be closely linked to hemodynamic stress and inflammatory pathways, most notably the NF-kB pathway. Therefore, it is a potential target for therapeutic intervention. In the present review, we investigated alterations in the vascular smooth muscle cells (VSMCs), extracellular matrix, and endothelial cells by the mediators implicated in the NF-kB pathway that lead to the formation, growth, and rupture of IAs. We also present an overview of the NF-kB pathway, focusing on stimuli and transcriptional targets specific to IAs, as well as a summary of the current strategies for inhibiting NF-kB activation in IAs. Our report adds to previously reported data and future research directions for treating IAs using compounds that can suppress inflammation in the vascular wall. |
| first_indexed | 2024-03-08T20:56:29Z |
| format | Article |
| id | doaj.art-2128f72d46e642cd9c5148b36ce8cdf4 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-08T20:56:29Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-2128f72d46e642cd9c5148b36ce8cdf42023-12-22T13:57:07ZengMDPI AGBrain Sciences2076-34252023-11-011312166010.3390/brainsci13121660The Role of the NF-kB Pathway in Intracranial AneurysmsLaurentiu Andrei Blaj0Andrei Ionut Cucu1Bogdan Ionel Tamba2Mihaela Dana Turliuc3Department of Neurosurgery, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania“Prof. Dr. N. Oblu” Emergency Clinical Hospital, 700309 Iasi, RomaniaAdvanced Research and Development Center for Experimental Medicine (CEMEX), “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Neurosurgery, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaThe pathophysiology of intracranial aneurysms (IA) has been proven to be closely linked to hemodynamic stress and inflammatory pathways, most notably the NF-kB pathway. Therefore, it is a potential target for therapeutic intervention. In the present review, we investigated alterations in the vascular smooth muscle cells (VSMCs), extracellular matrix, and endothelial cells by the mediators implicated in the NF-kB pathway that lead to the formation, growth, and rupture of IAs. We also present an overview of the NF-kB pathway, focusing on stimuli and transcriptional targets specific to IAs, as well as a summary of the current strategies for inhibiting NF-kB activation in IAs. Our report adds to previously reported data and future research directions for treating IAs using compounds that can suppress inflammation in the vascular wall.https://www.mdpi.com/2076-3425/13/12/1660intracranial aneurysmNF-kB pathwayinflammation |
| spellingShingle | Laurentiu Andrei Blaj Andrei Ionut Cucu Bogdan Ionel Tamba Mihaela Dana Turliuc The Role of the NF-kB Pathway in Intracranial Aneurysms Brain Sciences intracranial aneurysm NF-kB pathway inflammation |
| title | The Role of the NF-kB Pathway in Intracranial Aneurysms |
| title_full | The Role of the NF-kB Pathway in Intracranial Aneurysms |
| title_fullStr | The Role of the NF-kB Pathway in Intracranial Aneurysms |
| title_full_unstemmed | The Role of the NF-kB Pathway in Intracranial Aneurysms |
| title_short | The Role of the NF-kB Pathway in Intracranial Aneurysms |
| title_sort | role of the nf kb pathway in intracranial aneurysms |
| topic | intracranial aneurysm NF-kB pathway inflammation |
| url | https://www.mdpi.com/2076-3425/13/12/1660 |
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