From genes to modules, from cells to ecosystems
Abstract Twenty years ago, molecular biology transitioned from predominantly studying genes as isolated elements to viewing them as part of complex modules, giving rise to the field of systems biology. This transition was made possible by technological advances that allowed to simultaneously measure...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2022-05-01
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| Series: | Molecular Systems Biology |
| Online Access: | https://doi.org/10.15252/msb.202110726 |
| _version_ | 1827014817143062528 |
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| author | Tal Keidar Haran Leeat Keren |
| author_facet | Tal Keidar Haran Leeat Keren |
| author_sort | Tal Keidar Haran |
| collection | DOAJ |
| description | Abstract Twenty years ago, molecular biology transitioned from predominantly studying genes as isolated elements to viewing them as part of complex modules, giving rise to the field of systems biology. This transition was made possible by technological advances that allowed to simultaneously measure the expression levels of thousands of genes in a single experiment and drove a shift toward analyses identifying gene sets, modules, and pathways involved in a biological process of interest. Today we are excitingly facing a similar turning point in cell biology, where single‐cell technologies have enabled us to approach cells as cellular modules. |
| first_indexed | 2024-03-07T18:32:46Z |
| format | Article |
| id | doaj.art-2129c94e17194a798d02ae4eaf6cf495 |
| institution | Directory Open Access Journal |
| issn | 1744-4292 |
| language | English |
| last_indexed | 2025-02-18T14:14:02Z |
| publishDate | 2022-05-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj.art-2129c94e17194a798d02ae4eaf6cf4952024-10-28T09:18:55ZengSpringer NatureMolecular Systems Biology1744-42922022-05-011851310.15252/msb.202110726From genes to modules, from cells to ecosystemsTal Keidar Haran0Leeat Keren1Department of Pathology, Hadassah Medical CenterDepartment of Molecular Cell Biology, Weizmann Institute of ScienceAbstract Twenty years ago, molecular biology transitioned from predominantly studying genes as isolated elements to viewing them as part of complex modules, giving rise to the field of systems biology. This transition was made possible by technological advances that allowed to simultaneously measure the expression levels of thousands of genes in a single experiment and drove a shift toward analyses identifying gene sets, modules, and pathways involved in a biological process of interest. Today we are excitingly facing a similar turning point in cell biology, where single‐cell technologies have enabled us to approach cells as cellular modules.https://doi.org/10.15252/msb.202110726 |
| spellingShingle | Tal Keidar Haran Leeat Keren From genes to modules, from cells to ecosystems Molecular Systems Biology |
| title | From genes to modules, from cells to ecosystems |
| title_full | From genes to modules, from cells to ecosystems |
| title_fullStr | From genes to modules, from cells to ecosystems |
| title_full_unstemmed | From genes to modules, from cells to ecosystems |
| title_short | From genes to modules, from cells to ecosystems |
| title_sort | from genes to modules from cells to ecosystems |
| url | https://doi.org/10.15252/msb.202110726 |
| work_keys_str_mv | AT talkeidarharan fromgenestomodulesfromcellstoecosystems AT leeatkeren fromgenestomodulesfromcellstoecosystems |