Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast
Dot1 is an evolutionarily conserved enzyme, responsible for histone H3K79 methylation in most eukaryotes. Here authors show that, in yeast, Dot1p has histone chaperone activity and regulates nucleosome dynamics via histone exchange in transcribed regions.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02759-8 |
| _version_ | 1819126586967851008 |
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| author | Soyun Lee Seunghee Oh Kwiwan Jeong Hyelim Jo Yoonjung Choi Hogyu David Seo Minhoo Kim Joonho Choe Chang Seob Kwon Daeyoup Lee |
| author_facet | Soyun Lee Seunghee Oh Kwiwan Jeong Hyelim Jo Yoonjung Choi Hogyu David Seo Minhoo Kim Joonho Choe Chang Seob Kwon Daeyoup Lee |
| author_sort | Soyun Lee |
| collection | DOAJ |
| description | Dot1 is an evolutionarily conserved enzyme, responsible for histone H3K79 methylation in most eukaryotes. Here authors show that, in yeast, Dot1p has histone chaperone activity and regulates nucleosome dynamics via histone exchange in transcribed regions. |
| first_indexed | 2024-12-22T07:58:24Z |
| format | Article |
| id | doaj.art-212d26a446b048c1a4d3006d7bb52b5b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T07:58:24Z |
| publishDate | 2018-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-212d26a446b048c1a4d3006d7bb52b5b2022-12-21T18:33:19ZengNature PortfolioNature Communications2041-17232018-01-019111410.1038/s41467-017-02759-8Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeastSoyun Lee0Seunghee Oh1Kwiwan Jeong2Hyelim Jo3Yoonjung Choi4Hogyu David Seo5Minhoo Kim6Joonho Choe7Chang Seob Kwon8Daeyoup Lee9Department of Biological Sciences, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences, Korea Advanced Institute of Science and TechnologyBiocenter, Gyeonggi Business & Science AcceleratorDepartment of Biological Sciences, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences, Korea Advanced Institute of Science and TechnologyDepartment of Chemistry and Biology, Korea Science Academy of KAISTDepartment of Biological Sciences, Korea Advanced Institute of Science and TechnologyDot1 is an evolutionarily conserved enzyme, responsible for histone H3K79 methylation in most eukaryotes. Here authors show that, in yeast, Dot1p has histone chaperone activity and regulates nucleosome dynamics via histone exchange in transcribed regions.https://doi.org/10.1038/s41467-017-02759-8 |
| spellingShingle | Soyun Lee Seunghee Oh Kwiwan Jeong Hyelim Jo Yoonjung Choi Hogyu David Seo Minhoo Kim Joonho Choe Chang Seob Kwon Daeyoup Lee Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast Nature Communications |
| title | Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast |
| title_full | Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast |
| title_fullStr | Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast |
| title_full_unstemmed | Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast |
| title_short | Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast |
| title_sort | dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast |
| url | https://doi.org/10.1038/s41467-017-02759-8 |
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