Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from <i>Nepeta italica</i>
Plants from the <i>Nepeta</i> genus have been proved to possess different pharmacological properties, among which are antimicrobial, antioxidant, anti-inflammatory, analgesic, and cytotoxic effects. <i>Nepeta italica</i> is a medicinal plant traditionally used for its analges...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/15/2785 |
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| author | Alessandra Acquaviva Simonetta Cristina Di Simone Nilofar Abdelhakim Bouyahya Gokhan Zengin Lucia Recinella Sheila Leone Luigi Brunetti Abdullahi Ibrahim Uba Osman Guler Maruf Balos Ugur Cakilcioğlu Luigi Menghini Claudio Ferrante Giustino Orlando Maria Loreta Libero Annalisa Chiavaroli |
| author_facet | Alessandra Acquaviva Simonetta Cristina Di Simone Nilofar Abdelhakim Bouyahya Gokhan Zengin Lucia Recinella Sheila Leone Luigi Brunetti Abdullahi Ibrahim Uba Osman Guler Maruf Balos Ugur Cakilcioğlu Luigi Menghini Claudio Ferrante Giustino Orlando Maria Loreta Libero Annalisa Chiavaroli |
| author_sort | Alessandra Acquaviva |
| collection | DOAJ |
| description | Plants from the <i>Nepeta</i> genus have been proved to possess different pharmacological properties, among which are antimicrobial, antioxidant, anti-inflammatory, analgesic, and cytotoxic effects. <i>Nepeta italica</i> is a medicinal plant traditionally used for its analgesic effects, and in the present study, the phytochemical composition and biological effects of hexane, dichloromethane (DCM), ethyl acetate (EA), ethanol, ethanol-water, and water extracts of the aerial parts were investigated for determining phenolic composition, antioxidant effects, and anti-inflammatory effects in isolated mouse colon specimens exposed to lipopolysaccharide (LPS). Polar extracts were the richest in terms of phenolic compounds, especially rosmarinic acid. In parallel, ethanol, ethanol-water, and water extracts were also the most effective as scavenging/reducing and enzyme inhibition agents, especially towards cholinesterases and α-glucosidase, and in inhibiting the LPS-induced cyclooxygenase-2 (COX-2) and tumor necrosis factor α (TNFα) gene expression in mouse colon. This poses the basis for future in vivo investigations for confirming the protective effects of polar extracts of <i>N. italica</i> against inflammatory bowel diseases. |
| first_indexed | 2024-03-11T00:19:09Z |
| format | Article |
| id | doaj.art-212ebdfdebc348d898e5b4d4888df94c |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-11T00:19:09Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-212ebdfdebc348d898e5b4d4888df94c2023-11-18T23:25:50ZengMDPI AGPlants2223-77472023-07-011215278510.3390/plants12152785Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from <i>Nepeta italica</i>Alessandra Acquaviva0Simonetta Cristina Di Simone1Nilofar2Abdelhakim Bouyahya3Gokhan Zengin4Lucia Recinella5Sheila Leone6Luigi Brunetti7Abdullahi Ibrahim Uba8Osman Guler9Maruf Balos10Ugur Cakilcioğlu11Luigi Menghini12Claudio Ferrante13Giustino Orlando14Maria Loreta Libero15Annalisa Chiavaroli16Department of Pharmacy, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Pharmacy, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Pharmacy, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, ItalyLaboratory of Human Pathologies Biology, Faculty of Sciences, Department of Biology, Mohammed V University in Rabat, Rabat 10106, MoroccoPhysiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya 42130, TurkeyDepartment of Pharmacy, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Pharmacy, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Pharmacy, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Molecular Biology and Genetics, Istanbul AREL University, Istanbul 34537, TurkeyPertek Sakine Genç Vocational School, Munzur University, Pertek 62500, TurkeySanlıurfa Provincial Directorate of National Education, Sanlıurfa 63320, TurkeyPertek Sakine Genç Vocational School, Munzur University, Pertek 62500, TurkeyDepartment of Pharmacy, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Pharmacy, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Pharmacy, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Pharmacy, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Pharmacy, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, ItalyPlants from the <i>Nepeta</i> genus have been proved to possess different pharmacological properties, among which are antimicrobial, antioxidant, anti-inflammatory, analgesic, and cytotoxic effects. <i>Nepeta italica</i> is a medicinal plant traditionally used for its analgesic effects, and in the present study, the phytochemical composition and biological effects of hexane, dichloromethane (DCM), ethyl acetate (EA), ethanol, ethanol-water, and water extracts of the aerial parts were investigated for determining phenolic composition, antioxidant effects, and anti-inflammatory effects in isolated mouse colon specimens exposed to lipopolysaccharide (LPS). Polar extracts were the richest in terms of phenolic compounds, especially rosmarinic acid. In parallel, ethanol, ethanol-water, and water extracts were also the most effective as scavenging/reducing and enzyme inhibition agents, especially towards cholinesterases and α-glucosidase, and in inhibiting the LPS-induced cyclooxygenase-2 (COX-2) and tumor necrosis factor α (TNFα) gene expression in mouse colon. This poses the basis for future in vivo investigations for confirming the protective effects of polar extracts of <i>N. italica</i> against inflammatory bowel diseases.https://www.mdpi.com/2223-7747/12/15/2785<i>Nepeta italica</i>antioxidantrosmarinic acidanti-inflammatory |
| spellingShingle | Alessandra Acquaviva Simonetta Cristina Di Simone Nilofar Abdelhakim Bouyahya Gokhan Zengin Lucia Recinella Sheila Leone Luigi Brunetti Abdullahi Ibrahim Uba Osman Guler Maruf Balos Ugur Cakilcioğlu Luigi Menghini Claudio Ferrante Giustino Orlando Maria Loreta Libero Annalisa Chiavaroli Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from <i>Nepeta italica</i> Plants <i>Nepeta italica</i> antioxidant rosmarinic acid anti-inflammatory |
| title | Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from <i>Nepeta italica</i> |
| title_full | Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from <i>Nepeta italica</i> |
| title_fullStr | Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from <i>Nepeta italica</i> |
| title_full_unstemmed | Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from <i>Nepeta italica</i> |
| title_short | Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from <i>Nepeta italica</i> |
| title_sort | screening for chemical characterization and pharmacological properties of different extracts from i nepeta italica i |
| topic | <i>Nepeta italica</i> antioxidant rosmarinic acid anti-inflammatory |
| url | https://www.mdpi.com/2223-7747/12/15/2785 |
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