Pain Trajectories in Knee Osteoarthritis—A Systematic Review and Best Evidence Synthesis on Pain Predictors
Different profiles of pain progression have been reported in patients with knee osteoarthritis (OA), but the determinants of this heterogeneity are still to be sought. The aim of this systematic review was to analyze all studies providing information about knee OA pain trajectories to delineate, acc...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/9/9/2828 |
| _version_ | 1797554963916783616 |
|---|---|
| author | Davide Previtali Luca Andriolo Giorgio Di Laura Frattura Angelo Boffa Christian Candrian Stefano Zaffagnini Giuseppe Filardo |
| author_facet | Davide Previtali Luca Andriolo Giorgio Di Laura Frattura Angelo Boffa Christian Candrian Stefano Zaffagnini Giuseppe Filardo |
| author_sort | Davide Previtali |
| collection | DOAJ |
| description | Different profiles of pain progression have been reported in patients with knee osteoarthritis (OA), but the determinants of this heterogeneity are still to be sought. The aim of this systematic review was to analyze all studies providing information about knee OA pain trajectories to delineate, according to patients’ characteristics, an evidence-based evolution pattern of this disabling disease, which is key for a more personalized and effective management of knee OA. A literature search was performed on PubMed, Web of Science, Cochrane Library, and grey literature databases. The Cochrane Collaboration’s tool for assessing risk of bias was used, and a best-evidence synthesis was performed to define the predictors of pain evolution. Seven articles on 7747 patients affected by knee OA (mainly early/moderate) were included. Daily knee OA pain trajectories were unstable in almost half of the patients. In the mid-term, knee OA had a steady pain trajectory in 85% of the patients, 8% experienced pain reduction, while 7% experienced pain worsening. Low education, comorbidities, and depression were patient-related predictors of severe/worsening knee OA pain. Conversely, age, alcohol, smoking, pain coping strategies, and medications were unrelated to pain evolution. Conflicting/no evidence was found for all joint-related factors, such as baseline radiographic severity. |
| first_indexed | 2024-03-10T16:39:29Z |
| format | Article |
| id | doaj.art-212f0e7177774365ba9cd71c7b350e33 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T16:39:29Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-212f0e7177774365ba9cd71c7b350e332023-11-20T12:06:53ZengMDPI AGJournal of Clinical Medicine2077-03832020-09-0199282810.3390/jcm9092828Pain Trajectories in Knee Osteoarthritis—A Systematic Review and Best Evidence Synthesis on Pain PredictorsDavide Previtali0Luca Andriolo1Giorgio Di Laura Frattura2Angelo Boffa3Christian Candrian4Stefano Zaffagnini5Giuseppe Filardo6Orthopaedic and Traumatology Unit, Ospedale Regionale di Lugano, EOC, 6900 Lugano, SwitzerlandClinica Ortopedica e Traumatologica 2, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyOrthopaedic and Traumatology Unit, Ospedale Regionale di Lugano, EOC, 6900 Lugano, SwitzerlandClinica Ortopedica e Traumatologica 2, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyOrthopaedic and Traumatology Unit, Ospedale Regionale di Lugano, EOC, 6900 Lugano, SwitzerlandClinica Ortopedica e Traumatologica 2, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyOrthopaedic and Traumatology Unit, Ospedale Regionale di Lugano, EOC, 6900 Lugano, SwitzerlandDifferent profiles of pain progression have been reported in patients with knee osteoarthritis (OA), but the determinants of this heterogeneity are still to be sought. The aim of this systematic review was to analyze all studies providing information about knee OA pain trajectories to delineate, according to patients’ characteristics, an evidence-based evolution pattern of this disabling disease, which is key for a more personalized and effective management of knee OA. A literature search was performed on PubMed, Web of Science, Cochrane Library, and grey literature databases. The Cochrane Collaboration’s tool for assessing risk of bias was used, and a best-evidence synthesis was performed to define the predictors of pain evolution. Seven articles on 7747 patients affected by knee OA (mainly early/moderate) were included. Daily knee OA pain trajectories were unstable in almost half of the patients. In the mid-term, knee OA had a steady pain trajectory in 85% of the patients, 8% experienced pain reduction, while 7% experienced pain worsening. Low education, comorbidities, and depression were patient-related predictors of severe/worsening knee OA pain. Conversely, age, alcohol, smoking, pain coping strategies, and medications were unrelated to pain evolution. Conflicting/no evidence was found for all joint-related factors, such as baseline radiographic severity.https://www.mdpi.com/2077-0383/9/9/2828kneeosteoarthritispaintrajectoriespredictorsevolution |
| spellingShingle | Davide Previtali Luca Andriolo Giorgio Di Laura Frattura Angelo Boffa Christian Candrian Stefano Zaffagnini Giuseppe Filardo Pain Trajectories in Knee Osteoarthritis—A Systematic Review and Best Evidence Synthesis on Pain Predictors Journal of Clinical Medicine knee osteoarthritis pain trajectories predictors evolution |
| title | Pain Trajectories in Knee Osteoarthritis—A Systematic Review and Best Evidence Synthesis on Pain Predictors |
| title_full | Pain Trajectories in Knee Osteoarthritis—A Systematic Review and Best Evidence Synthesis on Pain Predictors |
| title_fullStr | Pain Trajectories in Knee Osteoarthritis—A Systematic Review and Best Evidence Synthesis on Pain Predictors |
| title_full_unstemmed | Pain Trajectories in Knee Osteoarthritis—A Systematic Review and Best Evidence Synthesis on Pain Predictors |
| title_short | Pain Trajectories in Knee Osteoarthritis—A Systematic Review and Best Evidence Synthesis on Pain Predictors |
| title_sort | pain trajectories in knee osteoarthritis a systematic review and best evidence synthesis on pain predictors |
| topic | knee osteoarthritis pain trajectories predictors evolution |
| url | https://www.mdpi.com/2077-0383/9/9/2828 |
| work_keys_str_mv | AT davideprevitali paintrajectoriesinkneeosteoarthritisasystematicreviewandbestevidencesynthesisonpainpredictors AT lucaandriolo paintrajectoriesinkneeosteoarthritisasystematicreviewandbestevidencesynthesisonpainpredictors AT giorgiodilaurafrattura paintrajectoriesinkneeosteoarthritisasystematicreviewandbestevidencesynthesisonpainpredictors AT angeloboffa paintrajectoriesinkneeosteoarthritisasystematicreviewandbestevidencesynthesisonpainpredictors AT christiancandrian paintrajectoriesinkneeosteoarthritisasystematicreviewandbestevidencesynthesisonpainpredictors AT stefanozaffagnini paintrajectoriesinkneeosteoarthritisasystematicreviewandbestevidencesynthesisonpainpredictors AT giuseppefilardo paintrajectoriesinkneeosteoarthritisasystematicreviewandbestevidencesynthesisonpainpredictors |